List of works - Christian Vaisse

A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans.

scientific article

A statistical approach for array CGH data analysis

scientific article

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier

scientific article published on June 2017

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study

scientific article published on 17 December 2008

Cilia and Obesity

scientific article published on 17 January 2017

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans

scientific article published on October 2004

Emerging trends in the search for genetic variants predisposing to human obesity

scientific article

Engineering the melanocortin-4 receptor to control G(s) signaling in vivo

scientific article

Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo

scientific article

Functional characterization of SIM1-associated enhancers

scientific article

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions

scientific article

High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes

scientific article published on 24 May 2005

Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia

scientific article

Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus

scientific article

In silico mutagenesis: a case study of the melanocortin 4 receptor

scientific article

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

scientific article published on January 2003

Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance

scientific article

Lack of support for the association between GAD2 polymorphisms and severe human obesity

scientific article published on 30 August 2005

Leptin regulation of bone resorption by the sympathetic nervous system and CART

scientific journal article

Lessons from extreme human obesity: monogenic disorders

scientific article published on September 2008

Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.

scientific article published on 24 June 2012

Medical sequencing at the extremes of human body mass

scientific article published on 5 March 2007

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating

scientific article

Molecular genetics of human obesity-associated MC4R mutations

scientific article

Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain

scientific article

Narrowing down the role of common variants in the genetic predisposition to obesity

scientific article published on 11 March 2009

Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function

scientific article

PAX4 gene variations predispose to ketosis-prone diabetes

scientific article

Replication and extension of association between common genetic variants in SIM1 and human adiposity

scientific article

The Association of Serum Leptin with Mortality in Older Adults

scientific article published on 16 October 2015

The human MC4R promoter: characterization and role in obesity

scientific article published in December 2003

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene

scientific article published on 02 September 2008

Weight Loss after Roux-en-Y Gastric Bypass in Obese Patients Heterozygous for MC4R Mutations ⬇️

scientific article published on July 1, 2011

List of works by Christian Vaisse

A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans.

A statistical approach for array CGH data analysis

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier

Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study

Cilia and Obesity

Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans

Emerging trends in the search for genetic variants predisposing to human obesity

Engineering the melanocortin-4 receptor to control G(s) signaling in vivo

Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo

Functional characterization of SIM1-associated enhancers

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions

High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes

Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia

Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus

In silico mutagenesis: a case study of the melanocortin 4 receptor

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance

Lack of support for the association between GAD2 polymorphisms and severe human obesity

Leptin regulation of bone resorption by the sympathetic nervous system and CART

Lessons from extreme human obesity: monogenic disorders

Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.

Medical sequencing at the extremes of human body mass

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating

Molecular genetics of human obesity-associated MC4R mutations

Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain

Narrowing down the role of common variants in the genetic predisposition to obesity

Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function

PAX4 gene variations predispose to ketosis-prone diabetes

Replication and extension of association between common genetic variants in SIM1 and human adiposity

The Association of Serum Leptin with Mortality in Older Adults

The human MC4R promoter: characterization and role in obesity

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene

Weight Loss after Roux-en-Y Gastric Bypass in Obese Patients Heterozygous for MC4R Mutations ⬇️