List of works - Pavel Kovarik

AREsite2: an enhanced database for the comprehensive investigation of AU/GU/U-rich elements

scientific article published on 23 November 2015

AREsite: a database for the comprehensive investigation of AU-rich elements

scientific article

Autophagy supports Candida glabrata survival during phagocytosis.

scientific article published on 6 October 2009

CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response

scientific article

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

scientific article

Competition of Candida glabrata against Lactobacillus is Hog1 dependent

scientific article published on 07 September 2018

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of and

scientific article published on 21 February 2019

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis

scientific article published on 05 February 2020

GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression.

scientific article published on March 1997

Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9.

scientific article published on 14 May 2008

HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.

scientific article published on 20 February 2017

IFNs and STATs in innate immunity to microorganisms

scientific article

IFNs and STATs in innate immunity to microorganisms

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

scientific article

Interferons limit inflammatory responses by induction of tristetraprolin

scientific article published on 02 March 2006

Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

scientific article published on September 1999

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection.

scientific article published on 7 November 2017

Nine-amino-acid transactivation domain: establishment and prediction utilities

scientific article

Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

scientific article published on 02 March 2022

Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons

scientific article

Posttranscriptional regulation of cytokine expression.

scientific article

Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription

scientific article

RPG1: an essential gene of saccharomyces cerevisiae encoding a 110-kDa protein required for passage through the G1 phase

scientific article published on 01 February 1998

Regulation of Candida glabrata oxidative stress resistance is adapted to host environment.

scientific article published on 13 December 2010

Responses of innate immune cells to group A Streptococcus

scientific article

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates.

scientific article published on March 1999

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

scientific article

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation ⬇️

scientific article published on July 1, 1998

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

scientific article published on November 1999

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.

scientific article published on 17 May 2018

The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment

article

The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes.

scientific article

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection

scientific article published on 15 May 2017

The innate immune response elicited by Group A Streptococcus is highly variable among clinical isolates and correlates with the emm type.

scientific article

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

scientific article published on 05 September 2019

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

scientific article

Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.

scientific article published on 16 July 2015

Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution

scientific article published on 13 May 2016

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

scientific article published on 19 June 2009

Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation

scientific article published on 20 December 2011

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection ⬇️

scientific article published on May 19, 2011

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

scientific article

Type I Interferons in Bacterial Infections: A Balancing Act.

scientific article published on 26 December 2016

Tyrosine kinase 2 controls IL-1ß production at the translational level

scientific article published on 16 August 2010

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation

scientific article

List of works by Pavel Kovarik

AREsite2: an enhanced database for the comprehensive investigation of AU/GU/U-rich elements

AREsite: a database for the comprehensive investigation of AU-rich elements

Autophagy supports Candida glabrata survival during phagocytosis.

CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

Competition of Candida glabrata against Lactobacillus is Hog1 dependent

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of and

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis

GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression.

Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9.

HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.

IFNs and STATs in innate immunity to microorganisms

IFNs and STATs in innate immunity to microorganisms

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

Interferons limit inflammatory responses by induction of tristetraprolin

Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection.

Nine-amino-acid transactivation domain: establishment and prediction utilities

Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons

Posttranscriptional regulation of cytokine expression.

Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription

RPG1: an essential gene of saccharomyces cerevisiae encoding a 110-kDa protein required for passage through the G1 phase

Regulation of Candida glabrata oxidative stress resistance is adapted to host environment.

Responses of innate immune cells to group A Streptococcus

Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates.

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation ⬇️

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.

The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment

The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes.

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection

The innate immune response elicited by Group A Streptococcus is highly variable among clinical isolates and correlates with the emm type.

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.

Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection ⬇️

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

Type I Interferons in Bacterial Infections: A Balancing Act.

Tyrosine kinase 2 controls IL-1ß production at the translational level

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation