List of works - Sophie Lotersztajn

15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors.

scientific article published on 27 July 2001

A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis

scientific article published on 11 November 2019

A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon

scientific article published in Nature

A high affinity calcium-stimulated magnesium-dependent ATPase in rat liver plasma membranes. Dependence of an endogenous protein activator distinct from calmodulin

scientific article published on 01 November 1981

A membrane-bound protein inhibitor of the high affinity Ca ATPase in rat liver plasma membranes

scientific article published on 01 June 1982

AJP-Cell Physiology begins a theme series on the control of the proteostasis network in health and diseases.

scientific article published on 25 May 2016

AJP-Cell begins a theme series on tissue fibrosis

scientific article published on 19 December 2012

AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease

scientific article published on 02 July 2014

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

scientific article published on 16 June 2014

Activation of Na+/Ca2+ exchange by adenosine in ewe heart sarcolemma is mediated by a pertussis toxin-sensitive G protein

scientific article published on 01 October 1990

Adipose tissue macrophages: MR tracking to monitor obesity-associated inflammation

scientific article

American Journal of Physiology-Cell Physiology initiates a series of articles around a theme: autophagy is the first theme

scientific article published on 13 January 2010

Antifibrogenic role of the cannabinoid receptor CB2 in the liver

scientific article

Antiproliferative effects of ET-1 in human liver Ito cells: an ETB- and a cyclic AMP-mediated pathway

scientific article published on 01 January 1995

Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin

scientific article published on 23 October 2013

Autophagy in chronic liver diseases: a friend rather than a foe?

scientific article published in March 2017

Autophagy in chronic liver diseases: the two faces of Janus

scientific article published on 30 November 2016

Autophagy in liver diseases: Time for translation?

scientific article published on 31 January 2019

Autophagy: a multifaceted partner in liver fibrosis

scientific article published on 31 August 2014

Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration

scientific article

Biological effects of C-type natriuretic peptide in human myofibroblastic hepatic stellate cells

scientific article published on 01 August 1999

Biological effects of sarafotoxin in rat liver

scientific article published on 01 March 1992

CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis

scientific article published on 21 May 2006

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis

scientific article

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

scientific article published on 06 September 2011

Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver

scientific article published on 19 November 2013

Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases

scientific article published on March 2007

Cannabinoid receptors as novel therapeutic targets for the management of non-alcoholic steatohepatitis.

scientific article published in December 2008

Cannabinoid receptors as therapeutic targets in the management of liver diseases

scientific article published on September 2008

Cannabinoid signaling and liver therapeutics

scientific article

Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.

scientific article published on 12 December 2007

Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model

scientific article published on 07 October 2016

Chronic hypocalcemia of vitamin D deficiency leads to lower intracellular calcium concentrations in rat hepatocytes

scientific article

Cigarette smoke exposure: a novel cofactor of NAFLD progression?

scientific article published on 10 June 2009

Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis

scientific article published on 12 June 2019

Coupling of endothelin B receptors to the calcium pump and phospholipase C via Gs and Gq in rat liver

scientific article published on 01 January 1994

Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C.

scientific article published in July 2005

Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C.

scientific article published on 28 November 2007

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity

scientific article published on 24 October 2008

Endocannabinoids and their role in fatty liver disease.

scientific article published on 07 May 2010

Endocannabinoids as novel mediators of liver diseases.

scientific article

Endothelin inhibits the calcium pump and stimulates phosphoinositide phospholipase C in liver plasma membranes via two different G proteins, Gs and Gq

scientific article published on 01 January 1993

Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors

scientific article published on 01 May 1997

Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition

scientific article published on 01 April 2000

Environmental factors as disease accelerators during chronic hepatitis C.

scientific article published on 28 January 2008

From the Editor's Desk…: December 2019

scientific article published on 01 December 2019

From the Editor's Desk…: November 2019

scientific article published on 15 October 2019

From the Editor's desk....: November 2018

From the Editor's desk....: September 2018

scientific article published on 15 August 2018

Glucagon-(19-29) exerts a biphasic action on the liver plasma membrane Ca2+ pump which is mediated by G proteins.

scientific article published on June 1990

Glucagon-(19-29), a Ca2+ pump inhibitory peptide, is processed from glucagon in the rat liver plasma membrane by a thiol endopeptidase

scientific article published on 01 December 1990

Gs mediates hormonal inhibition of the calcium pump in liver plasma membranes

scientific article published on 01 February 1993

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts

scientific article published in August 2003

Hepatic cytoprotection (5). Calcium and hepatotoxicity

scientific article published on 01 August 1989

Hepatic fibrosis: molecular mechanisms and drug targets

scientific article published in January 2005

Homocysteine decreases endothelin-1 production by cultured human endothelial cells.

scientific article published on July 1999

Human hepatic stellate cells are not permissive for hepatitis C virus entry and replication

scientific article

Human liver plasma membrane Ca-ATPase: Identification and sensitivity to calcium antagonists ⬇️

scientific article published on November 1, 1982

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

scientific article

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

scientific article published on 02 June 2020

Inhibition by glucagon of the calcium pump in liver plasma membranes.

scientific article published on July 1984

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Inhibition of the calcium pump by human parathyroid hormone-(1-34) and human calcitonin in liver plasma membranes

scientific article published on March 1990

Journal of Hepatology: The Home of Liver Research, 2015-2019

scientific article published on 01 December 2019

LC3-associated phagocytosis in myeloid cells, a fireman that restrains inflammation and liver fibrosis, via immunoreceptor inhibitory signalling

scientific article published on 21 May 2020

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling

scientific article published on 01 April 2020

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption

scientific article published on 02 May 2019

Long term in vivo biotransformation of iron oxide nanoparticles

M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease

scientific article published on 20 November 2013

M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease

scientific article published on 5 April 2014

MAIT cell inhibition promotes liver fibrosis regression by reprogramming macrophage phenotype

scientific article published in 2022

Macrophage autophagy protects against liver fibrosis in mice

scientific article published on 10 June 2015

Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts

scientific article published in September 2004

Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis

scientific article published on 10 September 2019

Mucosal-associated invariant T cells and disease

scientific article published on 01 October 2019

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver.

scientific article

New pieces in the complex puzzle of aberrant vacuolation. Focus on "Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency".

scientific article published on 3 August 2016

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking

scientific article published on 06 May 2015

Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice

scientific article

Pathophysiology of NASH: Perspectives for a Targeted Treatment ⬇️

scientific article published on January 1, 2013

Platelet-derived Growth Factor-BB and Thrombin Generate Positive and Negative Signals for Human Hepatic Stellate Cell Proliferation

scientific article published in Journal of Biological Chemistry

Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness.

scientific article published on 28 July 2017

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview

scientific article published on 16 March 2020

Regulation of liver plasma membrane Ca2+ pump

scientific article published on 01 January 1988

Reply: To PMID 23728734.

scientific article published on 30 September 2013

Reversion of hepatic stellate cell to a quiescent phenotype: From myth to reality?

scientific article published on 06 April 2013

Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump ⬇️

scientific article published on February 5, 1992

Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2.

scientific article published on September 1998

Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts

scientific article

Statins Modulate Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 in Human Hepatic Myofibroblasts

scientific article

Targeting cannabinoid receptors in hepatocellular carcinoma?

scientific article

Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis

scientific article

The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway

scientific article published on 27 June 2016

The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy

scientific article published on 26 February 2009

The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings

scientific article

The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis.

scientific article

The high affinity (Ca2+-Mg2+)-ATPase in liver plasma membranes is a Ca2+ pump. Reconstitution of the purified enzyme into phospholipid vesicles

scientific article published on 01 April 1987

The inhibitor of liver plasma membrane (Ca2+-Mg2+)-ATPase. Purification and identification as a mediator of glucagon action.

scientific article

The liver X receptor in hepatic stellate cells: a novel antifibrogenic target?

scientific article published on 23 July 2011

The liver plasma membrane Ca-ATPase

scientific article published on 01 January 1982

The metabolic syndrome and chronic liver disease

scientific article published on January 2014

The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing

scientific article published on 06 March 2007

Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

scientific article published on 28 December 2016

Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis

scientific article published on September 2017

When autophagy chaperones liver metabolism

scientific article published on 01 September 2014

[CB1 cannabinoid receptor antagonists: a novel approach for the treatment of liver fibrosis]

scientific article published on 01 August 2006

[Calcium and cell death]

scientific article published on 01 June 1987

[Endocannabinoids: therapeutic perspectives in chronic liver diseases]

scientific article published on 01 March 2007

[Endothelins and their non-vascular effects]

scientific article published on 01 February 1993

[Glucagon is processed to the (19-29) fragment at the level of the hepatocyte membrane]

scientific article published on 01 January 1989

[The endocannabinoid system as a novel target for the treatment of liver fibrosis]

scientific article published on 06 April 2007

List of works by Sophie Lotersztajn

15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors.

A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis

A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon

A high affinity calcium-stimulated magnesium-dependent ATPase in rat liver plasma membranes. Dependence of an endogenous protein activator distinct from calmodulin

A membrane-bound protein inhibitor of the high affinity Ca ATPase in rat liver plasma membranes

AJP-Cell Physiology begins a theme series on the control of the proteostasis network in health and diseases.

AJP-Cell begins a theme series on tissue fibrosis

AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

Activation of Na+/Ca2+ exchange by adenosine in ewe heart sarcolemma is mediated by a pertussis toxin-sensitive G protein

Adipose tissue macrophages: MR tracking to monitor obesity-associated inflammation

American Journal of Physiology-Cell Physiology initiates a series of articles around a theme: autophagy is the first theme

Antifibrogenic role of the cannabinoid receptor CB2 in the liver

Antiproliferative effects of ET-1 in human liver Ito cells: an ETB- and a cyclic AMP-mediated pathway

Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin

Autophagy in chronic liver diseases: a friend rather than a foe?

Autophagy in chronic liver diseases: the two faces of Janus

Autophagy in liver diseases: Time for translation?

Autophagy: a multifaceted partner in liver fibrosis

Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration

Biological effects of C-type natriuretic peptide in human myofibroblastic hepatic stellate cells

Biological effects of sarafotoxin in rat liver

CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver

Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases

Cannabinoid receptors as novel therapeutic targets for the management of non-alcoholic steatohepatitis.

Cannabinoid receptors as therapeutic targets in the management of liver diseases

Cannabinoid signaling and liver therapeutics

Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.

Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model

Chronic hypocalcemia of vitamin D deficiency leads to lower intracellular calcium concentrations in rat hepatocytes

Cigarette smoke exposure: a novel cofactor of NAFLD progression?

Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis

Coupling of endothelin B receptors to the calcium pump and phospholipase C via Gs and Gq in rat liver

Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C.

Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C.

Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity

Endocannabinoids and their role in fatty liver disease.

Endocannabinoids as novel mediators of liver diseases.

Endothelin inhibits the calcium pump and stimulates phosphoinositide phospholipase C in liver plasma membranes via two different G proteins, Gs and Gq

Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors

Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition

Environmental factors as disease accelerators during chronic hepatitis C.

From the Editor's Desk…: December 2019

From the Editor's Desk…: November 2019

From the Editor's desk....: November 2018

From the Editor's desk....: September 2018

From the Editor's desk....: September 2018

Glucagon-(19-29) exerts a biphasic action on the liver plasma membrane Ca2+ pump which is mediated by G proteins.

Glucagon-(19-29), a Ca2+ pump inhibitory peptide, is processed from glucagon in the rat liver plasma membrane by a thiol endopeptidase

Gs mediates hormonal inhibition of the calcium pump in liver plasma membranes

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts

Hepatic cytoprotection (5). Calcium and hepatotoxicity

Hepatic fibrosis: molecular mechanisms and drug targets

Homocysteine decreases endothelin-1 production by cultured human endothelial cells.

Human hepatic stellate cells are not permissive for hepatitis C virus entry and replication

Human liver plasma membrane Ca-ATPase: Identification and sensitivity to calcium antagonists ⬇️

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

Inhibition by glucagon of the calcium pump in liver plasma membranes.

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Inhibition of the calcium pump by human parathyroid hormone-(1-34) and human calcitonin in liver plasma membranes

Journal of Hepatology: The Home of Liver Research, 2015-2019

LC3-associated phagocytosis in myeloid cells, a fireman that restrains inflammation and liver fibrosis, via immunoreceptor inhibitory signalling

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption

Long term in vivo biotransformation of iron oxide nanoparticles

M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease

M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease

MAIT cell inhibition promotes liver fibrosis regression by reprogramming macrophage phenotype

Macrophage autophagy protects against liver fibrosis in mice

Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts

Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis

Mucosal-associated invariant T cells and disease

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver.

New pieces in the complex puzzle of aberrant vacuolation. Focus on "Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency".