List of works - Masaharu Noda

Structural parts involved in activation and inactivation of the sodium channel

scientific article published in Nature

Existence of distinct sodium channel messenger RNAs in rat brain

scientific journal article

Expression of functional sodium channels from cloned cDNA.

scientific article published in August 1986

Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta

scientific article

A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction

scientific article

Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori

scientific article published on 24 February 2003

Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina.

scientific article

Identification of retinal ganglion cells and their projections involved in central transmission of information about upward and downward image motion

scientific article

Visual projection map specified by topographic expression of transcription factors in the retina

scientific article published in August 1996

The subfornical organ is the primary locus of sodium-level sensing by Na(x) sodium channels for the control of salt-intake behavior.

scientific article

Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O.

scientific article published on 7 May 2006

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor

scientific article published on 5 October 2004

Expression of SPIG1 reveals development of a retinal ganglion cell subtype projecting to the medial terminal nucleus in the mouse

scientific article

Na(x) channel involved in CNS sodium-level sensing.

scientific article

Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization

scientific journal article

Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cells.

scientific article published on 20 November 2003

Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP

scientific journal article

The subfornical organ, a specialized sodium channel, and the sensing of sodium levels in the brain.

scientific article

Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

scientific article

Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice.

scientific article published in February 2005

Role of bone morphogenic protein 2 in retinal patterning and retinotectal projection.

scientific article published in October 2006

Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination

scientific article

CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms

scientific article published on 3 September 2003

Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia

scientific article

Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z

scientific journal article

Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION

scientific article published on 21 July 2016

Hydromineral neuroendocrinology: mechanism of sensing sodium levels in the mammalian brain.

scientific article published on 9 March 2007

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features

scientific journal article

The Na(x) Channel: What It Is and What It Does

scientific article

Endothelin-3 expression in the subfornical organ enhances the sensitivity of Na(x), the brain sodium-level sensor, to suppress salt intake.

scientific article

Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma

scientific article published on 9 February 2016

Characterization of rat receptor-like protein tyrosine phosphatase gamma isoforms

scientific journal article

Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.

scientific article published in September 2015

Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution

scientific article published on 12 July 2016

Sodium-level-sensitive sodium channel and salt-intake behavior.

scientific article published in January 2005

Large-scale identification and characterization of genes with asymmetric expression patterns in the developing chick retina.

scientific article published on April 2004

Sodium sensing in the subfornical organ and body-fluid homeostasis

scientific article published on 10 August 2016

Protamine neutralizes chondroitin sulfate proteoglycan-mediated inhibition of oligodendrocyte differentiation

scientific article published on 7 December 2017

Channel properties of Nax expressed in neurons

scientific article published on 11 May 2015

Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells

scientific article

A novel basic helix-loop-helix (bHLH) transcriptional repressor, NeuroAB, expressed in bipolar and amacrine cells in the chick retina.

scientific article published on September 2004

Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation.

scientific article published in June 2016

Identification of novel splicing variants of protein tyrosine phosphatase receptor type Z.

scientific article

Involvement of Nax sodium channel in peripheral nerve regeneration via lactate signaling

scientific article

The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice

scientific article published on 22 January 2019

Yeast substrate-trapping system for isolating substrates of protein tyrosine phosphatases

scientific article published on 01 January 2007

Adipsic hypernatremia without hypothalamic lesions accompanied by autoantibodies to subfornical organ

scientific article

Role of pleiotrophin-protein tyrosine phosphatase receptor type Z signaling in myelination

scientific article published on April 2016

PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance

scientific article published on 14 September 2017

Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ).

scientific article published on 13 June 2019

List of works by Masaharu Noda

Structural parts involved in activation and inactivation of the sodium channel

Existence of distinct sodium channel messenger RNAs in rat brain

Expression of functional sodium channels from cloned cDNA.

Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta

A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction

Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori

Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina.

Identification of retinal ganglion cells and their projections involved in central transmission of information about upward and downward image motion

Visual projection map specified by topographic expression of transcription factors in the retina

The subfornical organ is the primary locus of sodium-level sensing by Na(x) sodium channels for the control of salt-intake behavior.

Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O.

alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor

Expression of SPIG1 reveals development of a retinal ganglion cell subtype projecting to the medial terminal nucleus in the mouse

Na(x) channel involved in CNS sodium-level sensing.

Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization

Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cells.

Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP

The subfornical organ, a specialized sodium channel, and the sensing of sodium levels in the brain.

Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice.

Role of bone morphogenic protein 2 in retinal patterning and retinotectal projection.

Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination

CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms

Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia

Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z

Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION

Hydromineral neuroendocrinology: mechanism of sensing sodium levels in the mammalian brain.

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features

The Na(x) Channel: What It Is and What It Does

Endothelin-3 expression in the subfornical organ enhances the sensitivity of Na(x), the brain sodium-level sensor, to suppress salt intake.

Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma

Characterization of rat receptor-like protein tyrosine phosphatase gamma isoforms

Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.

Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution

Sodium-level-sensitive sodium channel and salt-intake behavior.

Large-scale identification and characterization of genes with asymmetric expression patterns in the developing chick retina.

Sodium sensing in the subfornical organ and body-fluid homeostasis

Protamine neutralizes chondroitin sulfate proteoglycan-mediated inhibition of oligodendrocyte differentiation

Channel properties of Nax expressed in neurons

Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells

A novel basic helix-loop-helix (bHLH) transcriptional repressor, NeuroAB, expressed in bipolar and amacrine cells in the chick retina.

Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation.

Identification of novel splicing variants of protein tyrosine phosphatase receptor type Z.

Involvement of Nax sodium channel in peripheral nerve regeneration via lactate signaling

The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice

Yeast substrate-trapping system for isolating substrates of protein tyrosine phosphatases

Adipsic hypernatremia without hypothalamic lesions accompanied by autoantibodies to subfornical organ

Role of pleiotrophin-protein tyrosine phosphatase receptor type Z signaling in myelination

PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance

Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ).