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List of works by Michael A Walters

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

scientific article published on 05 March 2019

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

scientific article published on 11 September 2019

ALARM NMR for HTS triage and chemical probe validation.

scientific article published in March 2018

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

scientific article published on 15 November 2017

Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

scientific article published on 20 November 2019

Chemistry: Chemical con artists foil drug discovery

scientific article

Curcumin May (Not) Defy Science.

scientific article

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

scientific article published on 08 July 2019

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

scientific article published on 16 March 2020

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

scientific article published on 19 March 2020

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

scientific article published on 17 July 2019

Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds

scientific article published on 17 February 2020

From HTS to Phase I: the Institute for Therapeutics Discovery and Development at the University of Minnesota

scientific article published in March 2014

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

scientific article published on 19 December 2017

Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases

scientific article

Mitigating risk in academic preclinical drug discovery

scientific article published on April 2015

Nuisance compounds in cellular assays

scientific article published in 2021

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

scientific article

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

scientific article published on 10 August 2015

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.

scientific article

Risk Management in Early Discovery Medicinal Chemistry

scientific article published on 19 October 2018

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains

scientific article

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity

scientific article published on 17 November 2020

The Essential Medicinal Chemistry of Curcumin

scientific article

The essential roles of chemistry in high-throughput screening triage

scientific article

The promise and peril of chemical probes

scientific article

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.

scientific article

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