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List of works by Melanie Königshoff

'WNT-er is coming': WNT signalling in chronic lung diseases.

scientific article

A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

scientific article published on 31 July 2021

An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices.

scientific article published on 17 March 2017

Applications and Approaches for 3D Precision-cut Lung Slices: Disease Modeling and Drug Discovery

scientific article published on 28 January 2020

Breaking the In Vitro Barrier in Respiratory Medicine: Engineered Microphysiological Systems for COPD and Beyond

scientific article published on 20 December 2017

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis

scientific article published in November 2018

Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

scientific article published on 9 January 2017

Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

article

Distinct niches within the extracellular matrix dictate fibroblast function in (cell-free) 3D lung tissue cultures.

scientific article published on 18 January 2018

Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended Ex Vivo Culture

scientific article published on 01 January 2020

Functional role and species-specific contribution of arginases in pulmonary fibrosis

scientific article published on 12 October 2007

Hyperoxia Injury in the Developing Lung is Mediated by Mesenchymal Expression of Wnt5A

scientific article published on 05 February 2020

Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease

scientific article

Increased Extracellular Vesicles Mediate WNT-5A Signaling in Idiopathic Pulmonary Fibrosis

scientific article published on 25 July 2018

Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention

scientific article published on 29 July 2010

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 04 November 2020

Listen to the WNT; It Talks: WNT7A Drives Epithelial–Mesenchymal Cross-Talk within the Fibrotic Niche in Idiopathic Pulmonary Fibrosis

scientific article published in 2023

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

scientific article published on 15 December 2016

Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics

scientific article published on 22 December 2021

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.

scientific article

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures.

scientific article

Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung

scientific article published on 22 December 2020

Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease.

scientific article published on 28 February 2017

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

scientific article published on 03 August 2017

Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis

scientific article published on 07 April 2022

The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis

scientific article published on 01 December 2019

The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis

scientific article published on June 2011

Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase

scientific article published on 13 July 2005

Towards a global initiative for fibrosis treatment (GIFT).

scientific article published in October 2017

WNT Signaling in Lung Aging and Disease.

scientific article published on December 2016

Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema

scientific article published on 11 June 2020

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