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List of works by Scott A. Guelcher

3D Printing of Tissue Engineered Constructs for In Vitro Modeling of Disease Progression and Drug Screening

scientific article published on 11 May 2016

3D bone models to study the complex physical and cellular interactions between tumor and the bone microenvironment

scientific article published on 30 March 2018

A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species.

scientific article published on February 2014

A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration

scientific article published in July 2010

A three-dimensional computational model of collagen network mechanics

scientific article

A transient cell-shielding method for viable MSC delivery within hydrophobic scaffolds polymerized in situ

scientific article published on 27 March 2015

Altering adsorbed proteins or cellular gene expression in bone-metastatic cancer cells affects PTHrP and Gli2 without altering cell growth.

scientific article published on 13 July 2015

Balancing the rates of new bone formation and polymer degradation enhances healing of weight-bearing allograft/polyurethane composites in rabbit femoral defects

scientific article published on 02 October 2013

Biocompatibility and chemical reaction kinetics of injectable, settable polyurethane/allograft bone biocomposites

scientific article

Biodegradable lysine-derived polyurethane scaffolds promote healing in a porcine full-thickness excisional wound model

scientific article

Biodegradable polyurethanes: synthesis and applications in regenerative medicine

scientific article published on March 2008

Biomaterial scaffolds for treating osteoporotic bone

scientific article

Bone Structural Components Regulating Sites of Tumor Metastasis ⬇️

scientific article published on June 1, 2011

Cellularized cylindrical fiber/hydrogel composites for ligament tissue engineering

scientific article published on 5 December 2013

Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds ⬇️

scientific article published on September 22, 2010

Compression-Resistant Polymer/Ceramic Composite Scaffolds Augmented with rhBMP-2 Promote New Bone Formation in a Nonhuman Primate Mandibular Ridge Augmentation Model

scientific article published on 01 May 2020

Compressive fatigue and fracture toughness behavior of injectable, settable bone cements

scientific article

Computational predictions of the tensile properties of electrospun fibre meshes: effect of fibre diameter and fibre orientation

scientific article published on 25 January 2008

Concurrent local delivery of diflunisal limits bone destruction but fails to improve systemic vancomycin efficacy during Staphylococcus aureus osteomyelitis

scientific article published on 27 April 2020

Contribution of bone tissue modulus to breast cancer metastasis to bone

scientific article published on 26 July 2011

D-amino acid inhibits biofilm but not new bone formation in an ovine model

scientific article published on 23 July 2015

Degradable Segmented Polyurethane Elastomers for Bone Tissue Engineering: Effect of Polycaprolactone Content ⬇️

scientific article published on May 11, 2012

Degradation of polypropylene in vivo: A microscopic analysis of meshes explanted from patients

scientific article published on 28 August 2015

Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence

scientific article

Design and development of reactive injectable and settable polymeric biomaterials

scientific article published on 10 May 2013

Dual delivery of an antibiotic and a growth factor addresses both the microbiological and biological challenges of contaminated bone fractures ⬇️

scientific article published on October 22, 2011

Dual-purpose bone grafts improve healing and reduce infection

scientific article published on 01 August 2011

Effect of fiber diameter and alignment of electrospun polyurethane meshes on mesenchymal progenitor cells

scientific article

Effects of Recombinant Human Bone Morphogenetic Protein-2 Dose and Ceramic Composition on New Bone Formation and Space Maintenance in a Canine Mandibular Ridge Saddle Defect Model

scientific article published on 22 January 2016

Effects of local delivery of D-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects

scientific article published on 5 July 2013

Effects of particle size and porosity on in vivo remodeling of settable allograft bone/polymer composites

scientific article published on 8 January 2015

Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments

scientific article

Enhanced Performance of Plasmid DNA Polyplexes Stabilized by a Combination of Core Hydrophobicity and Surface PEGylation

scientific article

Exploring the potential of polyurethane-based soft foam as cell-free scaffold for soft tissue regeneration

scientific article published on 12 April 2018

Extracellular matrix rigidity promotes invadopodia activity

scientific article published on 21 August 2008

Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation

scientific article

Fabrication of Trabecular Bone-Templated Tissue-Engineered Constructs by 3D Inkjet Printing

scientific article published on 11 September 2017

Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament–bone interface ⬇️

scientific article published on July 14, 2011

Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells

scientific article published on April 2016

Gel microstructure regulates proliferation and differentiation of MC3T3-E1 cells encapsulated in alginate beads ⬇️

scientific article published on January 18, 2012

Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma

scientific article published on 12 October 2016

Hydrogel-electrospun mesh composites for coronary artery bypass grafts

scientific article published on 08 January 2011

Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release

scientific article published on 03 April 2011

In vivo polypropylene mesh degradation is hardly a myth.

scientific article

Injectable and compression-resistant low-viscosity polymer/ceramic composite carriers for rhBMP-2 in a rabbit model of posterolateral fusion: a pilot study

scientific article

Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration

scientific article

Injectable foams for regenerative medicine

scientific article published on 11 October 2013

Injectable polyurethane composite scaffolds delay wound contraction and support cellular infiltration and remodeling in rat excisional wounds ⬇️

scientific article published on November 21, 2011

Injectable, compression-resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model

scientific article published on 16 May 2018

Injected biodegradable polyurethane scaffolds support tissue infiltration and delay wound contraction in a porcine excisional model

scientific article published on 7 September 2015

Investigating the Effects of Surface-Initiated Polymerization of ε-Caprolactone to Bioactive Glass Particles on the Mechanical Properties of Settable Polymer/Ceramic Composites.

scientific article

Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing

scientific article published on 26 September 2016

Local delivery of tobramycin from injectable biodegradable polyurethane scaffolds

scientific article published in January 2010

Local injection of lovastatin in biodegradable polyurethane scaffolds enhances bone regeneration in a critical-sized segmental defect in rat femora ⬇️

scientific article published on June 20, 2012

Localized low-dose rhBMP-2 is effective at promoting bone regeneration in mandibular segmental defects

scientific article published on 28 September 2018

Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells

scientific article

Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II.

scientific article

Measuring differences in compositional properties of bone tissue by confocal Raman spectroscopy

scientific article published on 20 May 2011

Nanocrystalline hydroxyapatite-poly(thioketal urethane) nanocomposites stimulate a combined intramembranous and endochondral ossification response in rabbits

scientific article published on 10 December 2019

Oxidation and degradation of polypropylene transvaginal mesh

scientific article published on 13 January 2017

Oxidatively Degradable Poly(thioketal urethane)/Ceramic Composite Bone Cements with Bone-Like Strength

scientific article published on 8 November 2016

Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth.

scientific article published on 18 January 2018

Poly(thioketal urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation

scientific article published on 09 January 2019

Porcine Ischemic Wound Healing Model for Preclinical Testing of Degradable Biomaterials

scientific article

Principles of computer-controlled linear motion applied to an open-source affordable liquid handler for automated micropipetting

scientific article published on 12 August 2020

Pro-angiogenic and Anti-inflammatory Regulation by Functional Peptides Loaded in Polymeric Implants for Soft Tissue Regeneration ⬇️

scientific article published on October 19, 2012

Remodeling of injectable, low-viscosity polymer/ceramic bone grafts in a sheep femoral defect model

scientific article published on 10 August 2016

Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis.

scientific article published on 20 June 2016

Resorbable Nanocomposites with Bone-Like Strength and Enhanced Cellular Activity

scientific article published on 11 May 2017

Response of bone marrow stromal cells to graded co-electrospun scaffolds and its implications for engineering the ligament-bone interface ⬇️

scientific article published on July 25, 2012

Sensing and modulation of invadopodia across a wide range of rigidities

scientific article

Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model

scientific article published on 26 June 2018

Static and cyclic mechanical loading of mesenchymal stem cells on elastomeric, electrospun polyurethane meshes

scientific article published on 3 June 2015

Substrate Modulus Regulates Osteogenic Differentiation of Rat Mesenchymal Stem Cells through Integrin β1 and BMP Receptor Type IA.

scientific article published on April 2016

Substrate modulus of 3D-printed scaffolds regulates the regenerative response in subcutaneous implants through the macrophage phenotype and Wnt signaling

scientific article published on 11 September 2015

Sustained local delivery of siRNA from an injectable scaffold ⬇️

scientific article published on November 5, 2011

Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model

scientific article published on 9 April 2010

Synthesis and characterization of an injectable allograft bone/polymer composite bone void filler with tunable mechanical properties.

scientific article published in August 2010

Synthesis and characterization of segmented poly(esterurethane urea) elastomers for bone tissue engineering

scientific article

Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds

scientific article published on May 2006

Synthesis of biocompatible segmented polyurethanes from aliphatic diisocyanates and diurea diol chain extenders

scientific article published on 31 March 2005

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants ⬇️

scientific article published on September 26, 2011

Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit.

scientific article

Synthesis, in vitro degradation, and mechanical properties of two-component poly(ester urethane)urea scaffolds: effects of water and polyol composition

scientific article published on September 2007

Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates

scientific article published on 5 February 2008

Synthetic and tissue-derived models for studying rigidity effects on invadopodia activity

scientific article published on January 2013

Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease

scientific article published on 05 September 2019

The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds

scientific article published on 28 March 2009

The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora

scientific article published on 17 September 2009

Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.

scientific article published on 16 December 2013

Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction

scientific article published on 08 January 2020

Two-particle dynamics on an electrode in ac electric fields

scientific article published on 01 February 2002

Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels

scientific article published on 22 August 2014

Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer

scientific article

siRNA Delivery from an Injectable Scaffold for Wound Therapy

scientific article

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