List of works - Dag Sehlin

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

scientific article published on 6 January 2017

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

scientific article published on 22 August 2009

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

scientific article published on 19 February 2016

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways.

scientific article published on 3 February 2014

Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

scientific article published on 2 January 2018

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.

scientific article published on January 2017

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting.

scientific article published on 12 October 2016

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

scientific article published on 02 June 2021

Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

scientific article published on 19 January 2018

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment.

scientific article published on 14 September 2017

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.

scientific article

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.

scientific article published on 15 September 2017

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.

scientific article

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

scientific article published on 25 November 2020

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

scientific article published in 2022

Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-Aβ Antibodies

scientific article published on 13 August 2010

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer's patients and controls: impact on translational drug development

article

Increased Number of Plasma B Cells Producing Autoantibodies Against Aβ42 Protofibrils in Alzheimer's Disease.

scientific article published on August 2015

Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease

scientific article

Interference from heterophilic antibodies in amyloid-β oligomer ELISAs

scientific article published on 01 January 2010

Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation

scientific article (publication date: 2012)

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

scientific article published on 28 September 2021

Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

scientific article published on 24 March 2014

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β.

scientific article published on 8 December 2017

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer's disease

scientific article published on 21 September 2020

Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease

scientific article

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.

scientific article published in January 2013

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death.

scientific article published on 28 March 2018

List of works by Dag Sehlin

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways.

Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting.

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment.

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-Aβ Antibodies

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer's patients and controls: impact on translational drug development

Increased Number of Plasma B Cells Producing Autoantibodies Against Aβ42 Protofibrils in Alzheimer's Disease.

Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease

Interference from heterophilic antibodies in amyloid-β oligomer ELISAs

Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β.

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer's disease

Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death.