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List of works by Hening Lin

A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7

scientific article published on 04 February 2019

A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors

scientific article published on 02 August 2019

A Regulatory Cysteine Residue Mediates Reversible Inactivation of NAD+-Dependent Aldehyde Dehydrogenases to Promote Oxidative Stress Response

scientific article published on 16 December 2019

A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis

scientific article published on 07 October 2020

A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation

scientific article published on 25 February 2019

Activity-Guided Design of HDAC11-Specific Inhibitors

scientific article published on 02 July 2019

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease

scientific article published on 10 January 2022

An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3.

scientific article published on 21 January 2016

Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification

scientific article published on 3 October 2016

Chemical complementation: a reaction-independent genetic assay for enzyme catalysis.

scientific article

Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b

scientific article published on 20 December 2017

Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities

scientific article published on 13 August 2018

Directed evolution of a glycosynthase via chemical complementation.

scientific article published in November 2004

Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies.

scientific article published on 23 February 2015

Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent.

scientific article published in November 2004

Garcinol Is an HDAC11 Inhibitor

scientific article published on 09 October 2020

HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2

scientific article published on 28 February 2019

HPLC-Based Enzyme Assays for Sirtuins

scientific article published on 01 January 2018

High-throughput selection for cellulase catalysts using chemical complementation

scientific article

Identifying the functional contribution of the defatty-acylase activity of SIRT6.

scientific article published on 20 June 2016

In Vivo Protein-Protein Interaction Assays: Beyond Proteins We would like to thank Tony Siu, Dr. Charles Cho, and the members of our lab for their helpful comments as we were preparing this manuscript

scientific article published on 01 March 2001

Introduction: Posttranslational Protein Modification

scientific article published in February 2018

Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.

scientific article published in April 2009

Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases with Clickable NAD Analog.

scientific article published on March 2012

Lessons learned from a SIRT2-selective inhibitor

scientific article published on 30 March 2016

Lysine fatty acylation promotes lysosomal targeting of TNF-α

scientific article published on 15 April 2016

Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase.

scientific article published in December 2004

Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis

scientific article published on 01 January 2018

Molecular dissection of a putative iron reductase from Desulfotomaculum reducens MI-1.

scientific article

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

scientific article published on 26 February 2020

Non-canonical radical SAM enzyme chemistry learned from diphthamide biosynthesis.

scientific article published on 30 April 2018

Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model

scientific article published on 15 April 2019

Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation

scientific article published on 25 July 2006

Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.

scientific article published in March 2018

Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout.

scientific article published on 12 December 2017

Programming peptidomimetic syntheses by translating genetic codes designed de novo ⬇️

scientific article published on May 16, 2003

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

scientific article published on 2 January 2018

Protein lysine acylation and cysteine succination by intermediates of energy metabolism

scientific article

Protein posttranslational modifications: chemistry, biology, and applications

scientific article published on 25 November 2010

Reconstitution of diphthine synthase activity in vitro

scientific article

S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?

scientific article published on 28 June 2011

S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.

scientific article published on 14 February 2017

SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration

scientific article published on 03 September 2019

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.

scientific article published on 14 December 2017

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

scientific article published on 16 December 2019

SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.

scientific article published on 13 April 2017

SIRT7 Is an RNA-Activated Protein Lysine Deacylase

scientific article published on 20 December 2016

Screening and selection methods for large-scale analysis of protein function

scientific article published in December 2002

Selective usage of isozymes for stress response

article

Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy

scientific article published on 21 September 2020

Sirtuin inhibitors as anticancer agents.

scientific article published on May 2014

Sirtuins in epigenetic regulation

scientific article

Structural Basis of the Substrate Selectivity of Viperin

scientific article published on 16 January 2020

Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis

scientific article published on 6 April 2017

The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis

scientific article published on 14 October 2019

The Substrate Specificity of Sirtuins

scientific article published on 18 April 2016

The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis

scientific article published on 28 August 2019

The biosynthesis and biological function of diphthamide ⬇️

scientific article published on August 23, 2013

Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.

scientific article

Thiosuccinyl Peptides as Sirt5-Specific Inhibitors ⬇️

scientific article published on January 20, 2012

TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis

scientific article published on 01 June 2020

Updates on the epigenetic roles of sirtuins

scientific article published on 12 March 2019

Using Clickable NAD+ Analogs to Label Substrate Proteins of PARPs

scientific article published in January 2017

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