Search filters

List of works by Aled Edwards

1.6 A crystal structure of a PA2721 protein from pseudomonas aeruginosa--a potential drug-resistance protein

scientific article published on June 2006

1H, 15N and 13C resonance assignments for the C-terminal protein interaction region of the 32 kDa subunit of human replication protein A

scientific article published on 01 June 2000

A Call for Systematic Research on Solute Carriers

scientific article (publication date: 30 July 2015)

A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5

scientific article published in Journal of Biological Chemistry

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

scientific article

A conserved spiral structure for highly diverged phage tail assembly chaperones

scientific article

A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair

scientific article

A future for the protein structure initiative.

scientific article

A generalizable pre-clinical research approach for orphan disease therapy

scientific article published on 15 June 2012

A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats

scientific article

A novel member of the split betaalphabeta fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae

scientific article (publication date: May 2003)

A practical and robust sequence search strategy for structural genomics target selection

scientific article published on 16 June 2004

A proposal for validation of antibodies.

scientific article published on 5 September 2016

A public-private partnership to unlock the untargeted kinome

scientific article published in January 2013

A robust purification strategy to accelerate membrane proteomics

scientific article published on April 2007

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

scientific article published on 23 October 2009

A trust approach for sharing research reagents.

scientific article published on May 2017

Altered expression of genes involved in hepatic morphogenesis and fibrogenesis are identified by cDNA microarray analysis in biliary atresia

article

An NMR approach to structural proteomics

scientific article

An extremely SAD case: structure of a putative redox-enzyme maturation protein from Archaeoglobus fulgidus at 3.4 A resolution

scientific article

Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family

scientific article

Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643

scientific article

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering

scientific article

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

scientific article published on 29 June 2015

Bermuda Principles meet structural biology

Biochemical and Structural Characterization of a Novel Family of Cystathionine β-Synthase Domain Proteins Fused to a Zn Ribbon-Like Domain

scientific article

Biochemical characterization of FIKK8--A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans

scientific article (publication date: June 2015)

Bridging structural biology and genomics: assessing protein interaction data with known complexes

scientific article

Bridging structural biology and genomics: assessing protein interaction data with known complexes

scientific article published on 01 October 2002

Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection

scientific article published on 6 November 2009

Characterization of binding-induced changes in dynamics suggests a model for sequence-nonspecific binding of ssDNA by replication protein A.

scientific article published on October 2002

Chemical deglycosylation on a micro-scale of membrane glycoproteins with retention of phosphoryl-protein linkages

scientific article published on 01 November 1989

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

scientific article published on 11 October 2006

Clinical features of lichen sclerosus in men attending a department of genitourinary medicine

scientific article

Conserved protein YecM fromEscherichia coli shows structural homology to metal-binding isomerases and oxygenases

scientific article (publication date: May 2003)

Correction: Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

scientific article

Crystal Structure of Thermotoga maritima 0065, a Member of the IclR Transcriptional Factor Family

scientific article

Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain

scientific article

Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum

scientific article

Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase

scientific article published in November 2002

Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold

scientific article

Crystal structure of a predicted precorrin-8x methylmutase from Thermoplasma acidophilum

scientific article published on February 2005

Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins

scientific article

Crystal structure of bacteriophage lambda cII and its DNA complex

scientific article

Crystal structure of glutamine amidotransferase fromThermotoga maritima

scientific article

Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa

scientific article

Crystal structure of the CorA Mg2+ transporter

scientific article

Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA.

scientific article

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

scholarly article

Crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum: a new type of helical super-bundle

scientific article published on January 2004

Crystal structure ofEscherichia coli EC1530, a glyoxylate induced protein YgbM

scientific article

Crystal structures of MTH1187 and its yeast ortholog YBL001c

scientific article

Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit

scientific article

Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens

scientific article

Deep trefoil knot implicated in RNA binding found in an archaebacterial protein

scientific article

Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor

scientific article published on 24 January 2017

Dissociable Rpb4-Rpb7 subassembly of rna polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation.

scientific article

Donated chemical probes for open science

scientific article published on 20 April 2018

Elongation factor TFIIS contains three structural domains: solution structure of domain II

scientific article

Elongin from Saccharomyces cerevisiae.

scientific article

Enzyme genomics: Application of general enzymatic screens to discover new enzymes.

scientific article

Epitaxial growth of protein crystals from two-dimensional crystals on lipid layers.

scientific article published on October 1995

Epitaxial growth of protein crystals on lipid layers

scientific article published on 01 March 1994

Erratum: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

article

Erratum: Corrigendum: The promise and peril of chemical probes

scientific article published in November 2015

From clone to crystal: maximizing the amount of protein samples for structure determination.

scientific article

Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1

scientific article

Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.

scientific article published on 12 June 2015

Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro

scientific article

Functional similarities between phage lambda Orf and Escherichia coli RecFOR in initiation of genetic exchange

scientific article

Gene expression profiling of acute liver stress during living donor liver transplantation

scientific article published in April 2006

Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid

scientific article published on 15 April 2008

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms

scientific article published on 13 November 2006

Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family

scientific article published on 21 September 2006

Hepatic gene expression and prediction of therapy response in chronic hepatitis C patients

scientific article published on 29 February 2008

Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection

scientific article published in May 2005

High throughput screening of purified proteins for enzymatic activity

scientific article published on 01 January 2008

High-throughput production of prokaryotic membrane proteins

scientific article published in January 2005

High-throughput protein crystallization

Highlights of B/D-HPP and HPP Resource Pillar Workshops at 12th Annual HUPO World Congress of Proteomics: September 14-18, 2013, Yokohama, Japan

scientific article published in May 2014

ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment

scientific article published on 21 October 2009

Ideation and implementation of an open science drug discovery business model - M4K Pharma

scientific article published on 06 December 2018

Identifying regulators of transcript elongation in eukaryotes

scientific article published in January 1996

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

scientific article published on 15 October 2019

In situ proteolysis for protein crystallization and structure determination

scientific article

In situ proteolysis to generate crystals for structure determination: an update

scientific article

In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS

scientific article

Integrating Structure, Bioinformatics, and Enzymology to Discover Function: BioH, A NEW CARBOXYLESTERASE FROM ESCHERICHIA COLI

scientific article (publication date: 11 July 2003)

Interventions for improving understanding and minimising the psychological impact of screening

scientific article (publication date: 22 April 2003)

Intrinsic transcript cleavage in yeast RNA polymerase II elongation complexes

scientific article published on 11 April 2003

Large-scale structural biology of the human proteome

scientific article published on January 2009

Leveraging an Open Science Drug Discovery Model to Develop CNS Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma

scientific article published on 11 August 2020

Leveraging crowdsourcing to facilitate the discovery of new medicines

scientific article

MAID : an effect size based model for microarray data integration across laboratories and platforms

scientific article

Methyltransferase That Modifies Guanine 966 of the 16 S rRNA: FUNCTIONAL IDENTIFICATION AND TERTIARY STRUCTURE

scientific article

Molecular characteristics of the epitope in myelin-associated glycoprotein that is recognized by a monoclonal IgM in human neuropathy patients

scientific article published on 01 August 1984

Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha

scientific article

NMR and X-ray crystallography, complementary tools in structural proteomics of small proteins.

scientific article

NMR structure of the Escherichia coli protein YacG: a novel sequence motif in the zinc-finger family of proteins

scientific article

NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli

article

New approaches to rewarding pharmaceutical innovation

scientific article

Open access chemical and clinical probes to support drug discovery

scientific article

Open-source science to enable drug discovery

Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins

scientific article published on 5 October 2015

Origin DNA-binding proteins ⬇️

scientific article published on February 1, 1998

Overexpression, Purification, and Crystallization of the DNA Binding and Dimerization Domains of the Epstein-Barr Virus Nuclear Antigen 1 ⬇️

scientific article published on September 1, 1995

Personalised risk communication for informed decision making about entering screening programs

scientific article

Perspective: Science is still too closed

scientific article published in Nature

Phosphorylation of Myelin-Associated Glycoprotein In Vivo and In Vitro Occurs Only in the Cytoplasmic Domain of the Large Isoform

scientific article published on 01 January 1989

Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria

scientific article

Preclinical target validation using patient-derived cells

scientific article

Proteasome inhibition in vivo promotes survival in a lethal murine model of severe acute respiratory syndrome

scientific article

Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins

scientific article

Protein production and purification

scientific article

RNA polymerase II subunit Rpb9 regulates transcription elongation in vivo

scientific article published in November 2000

RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability

article

Refolding out of guanidine hydrochloride is an effective approach for high-throughput structural studies of small proteins

scientific article published in September 2003

Repeated tertiary fold of RNA polymerase II and implications for DNA binding

scientific article

Replication protein A. Characterization and crystallization of the DNA binding domain.

scientific article published on January 1997

Reproducibility: Team up with industry

scientific article published in March 2016

Shared decision making and the concept of equipoise: the competences of involving patients in healthcare choices

scientific article

Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection

scientific article published on 22 August 2006

Sodium cromoglycate in childhood asthma

scientific article

Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide

scientific article

Solution structure of ribosomal protein S28E fromMethanobacterium thermoautotrophicum

scientific article

Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum

scientific article

Solution structure of the hypothetical protein MTH0637 from Methanobacterium thermoautotrophicum.

scientific article

Solution structure of the yeast ubiquitin-like modifier protein Hub1

scientific article

Stopping pandemics before they start: Lessons learned from SARS-CoV-2

scientific article published on 10 March 2022

Strategies for structural proteomics of prokaryotes: Quantifying the advantages of studying orthologous proteins and of using both NMR and X-ray crystallography approaches

scientific article published in February 2003

Structural Genomics and Drug Discovery

Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics

scientific article published on 01 March 2003

Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis

scientific article

Structural and Biochemical Characterization of Phage   FI Protein (gpFI) Reveals a Novel Mechanism of DNA Packaging Chaperone Activity

scientific article

Structural and Biochemical Characterization of the Type II Fructose-1,6-bisphosphatase GlpX from Escherichia coli

scientific article

Structural and Functional Studies of gpX of Escherichia coli Phage P2 Reveal a Widespread Role for LysM Domains in the Baseplates of Contractile-Tailed Phages.

scientific article published in June 2014

Structural and chemical profiling of the human cytosolic sulfotransferases

scientific article

Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages

scientific article published on 4 October 2013

Structural bioinformatics: from protein structure to function

Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members

scientific article

Structural characterization of the putative ABC-type 2 transporter from Thermotoga maritima MSB8.

scientific article

Structural genomics of human proteins

scientific article published on January 2014

Structural insights into aldosterone synthase substrate specificity and targeted inhibition

scientific article

Structural proteomics: a tool for genome annotation

scientific article published on February 2004

Structure and biochemical functions of SIRT6.

scientific article

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

scientific article

Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer.

scientific article

Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase

scientific article

Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization

scientific article (publication date: April 2005)

Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum

scientific article

Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum

scientific article

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

scientific article

Tail tip proteins related to bacteriophage λ gpL coordinate an iron-sulfur cluster

scientific article

Target 2035: probing the human proteome

scientific article published on 03 July 2019

Target selection and determination of function in structural genomics

scientific article

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

scientific article published on 05 May 2020

Ten simple rules for cultivating open science and collaborative R&D;

scientific article (publication date: 2013)

The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction

scientific article

The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis

scientific article published on December 2009

The Drosophila nuclear receptor e75 contains heme and is gas responsive

scientific article

The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities

scientific article

The Mechanism of Protein Crystal Growth from Lipid Layers

The Precompetitive Space: Time to Move the Yardsticks

article published in 2011

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

scientific article published on 07 April 2020

The RPA32 Subunit of Human Replication Protein A Contains a Single-stranded DNA-binding Domain ⬇️

scientific article published on February 13, 1998

The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism

scientific article

The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ

scientific article

The bacteriophage HK97 gp15 moron element encodes a novel superinfection exclusion protein

scientific article published on 13 July 2012

The biology/disease-driven human proteome project (B/D-HPP): enabling protein research for the life sciences community

scientific article published on 21 December 2012

The characterization and cellular distribution of a family of antigens related to myelin associated glycoprotein in the developing nervous system

scientific article published in December 1985

The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis

scientific article

The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii

scientific article published on 31 October 2005

The crystal structure of hypothetical protein MTH1491 fromMethanobacterium thermoautotrophicum

scientific article

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

scientific article

The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold.

scientific article

The promise and peril of chemical probes

scientific article

The solution structure of the C-terminal Ig-like domain of the bacteriophage λ tail tube protein

scientific article

The structural basis for methylmalonic aciduria. The crystal structure of archaeal ATP:cobalamin adenosyltransferase

scientific article published on 25 March 2004

The structural basis of ZMPSTE24-dependent laminopathies

scientific article

Three-dimensional structure of yeast RNA polymerase II at 16 A resolution

scientific article published in July 1991

Too many roads not taken

scientific article

Transcription elongation through DNA arrest sites. A multistep process involving both RNA polymerase II subunit RPB9 and TFIIS.

scientific article published on 6 June 1997

Two domains of the epstein-barr virus origin DNA-binding protein, EBNA1, orchestrate sequence-specific DNA binding

scientific article published in July 2000

Two-dimensional and epitaxial crystallization of a mutant form of yeast RNA polymerase II.

scientific article published in September 1991

Unfolding of microarray data.

scientific article

Use of Limited Proteolysis to Identify Protein Domains Suitable for Structural Analysis

article

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

scientific article published on 11 September 2020

X-ray crystal structure of CutA from Thermotoga maritima at 1.4 Å resolution

scientific article

Yeast RNA Polymerase II Subunit RPB9

scientific article published in Journal of Biological Chemistry

Yeast Transcript Elongation Factor (TFIIS), Structure and Function

scientific article published in Journal of Biological Chemistry

Yeast Transcript Elongation Factor (TFIIS), Structure and Function

scientific article published on 01 August 1998

Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum

scientific article

[11] Two-dimensional protein crystals in aid of three-dimensional protein crystal growth

scientific article

[38] RNA polymerase II transcription in vitro

scientific article published on 01 January 1991

Paulina is supported by:

About Paulina

Help