List of works - Suzanne R Pfeffer

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

scientific article

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

scientific article published in 2022

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

scientific article published on 06 November 2018

Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi

scientific article published on January 1987

CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

Clues to NPC1-mediated cholesterol export from lysosomes

scientific article published on 07 July 2016

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.

scientific article published on 22 August 2016

Exosome-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity

Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells

scientific article

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

scientific article published on 15 May 2020

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

LRRK2 and Rab GTPases

scientific article published on 22 November 2018

LRRK2 phosphorylation of Rab GTPases in Parkinson's disease

scientific article published in 2022

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

scientific article published on 29 April 2020

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

Lipoprotein secretion: It takes two to TANGO.

scientific article published on 2 May 2016

Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis

Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export

scientific article published on 24 September 2016

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

scientific article published on 17 October 2019

Microscale Thermophoresis determination of Rab29 binding to LRRK2 Armadillo Domain v1

Multiple routes of protein transport from endosomes to the trans Golgi network

scientific article published on 29 October 2009

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

scientific article published on 01 February 2019

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

scientific article published on 30 October 2019

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins

scientific article published in 2021

Protein flexibility is required for vesicle tethering at the Golgi.

scientific article

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

scientific article published on 6 December 2017

Rab29 fast exchange mutants: characterization of a challenging Rab GTPase v1

Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering

scientific article published on 30 March 2015

Reconstitution of LRRK2 membrane recruitment onto planar lipid bilayers v1

Suzanne Pfeffer: sorting through membrane trafficking. Interview by Caitlin Sedwick

scientific article published in April 2009

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

scientific article published on 10 November 2017

Transport Vesicle Tethering at the Trans Golgi Network: Coiled Coil Proteins in Action

scientific article

List of works by Suzanne R Pfeffer

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi

CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

Clues to NPC1-mediated cholesterol export from lysosomes

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.

Exosome-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity

Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

LRRK2 and Rab GTPases

LRRK2 phosphorylation of Rab GTPases in Parkinson's disease

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

Lipoprotein secretion: It takes two to TANGO.

Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis

Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

Microscale Thermophoresis determination of Rab29 binding to LRRK2 Armadillo Domain v1

Multiple routes of protein transport from endosomes to the trans Golgi network

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins

Protein flexibility is required for vesicle tethering at the Golgi.

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

Rab29 fast exchange mutants: characterization of a challenging Rab GTPase v1

Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering

Reconstitution of LRRK2 membrane recruitment onto planar lipid bilayers v1

Suzanne Pfeffer: sorting through membrane trafficking. Interview by Caitlin Sedwick

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Transport Vesicle Tethering at the Trans Golgi Network: Coiled Coil Proteins in Action