List of works - Tim Elliott

A Mechanistic Model for Predicting Cell Surface Presentation of Competing Peptides by MHC Class I Molecules

scientific article published on 05 July 2018

A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins.

scientific article published on 27 September 2013

A peptide filtering relation quantifies MHC class I peptide optimization

scientific article published in October 2011

Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope

scientific article published on 30 November 2009

Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin

scientific article

Assembly and export of MHC class I peptide ligands

scientific article (publication date: February 2003)

Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function

scientific article published on 27 July 2016

Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses.

scientific article

CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains.

scientific article published on 20 November 2017

Common variable immunodeficiency is associated with a functional deficiency of invariant natural killer T cells.

scientific article

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

scientific article published on February 2014

DNA Fusion Vaccine Designed to Induce Cytotoxic T Cell Responses Against Defined Peptide Motifs: Implications for Cancer Vaccines

scientific article published in August 2001

DNA transfection screening from single beads.

scientific article published in September 2004

Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens

article

Differential suppression of tumor-specific CD8+ T cells by regulatory T cells.

scientific article published on 4 October 2010

Direct deprotected glycosyl–asparagine ligation

scientific article published in 2006

Direct evidence for conformational dynamics in major histocompatibility complex class I molecules.

scientific article published on 11 October 2017

Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation

scientific article published on 4 September 2013

ERAP1 in the pathogenesis of ankylosing spondylitis.

scientific article published on December 2014

ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity

scientific article published on 05 February 2009

Evidence for successive peptide binding and quality control stages during MHC class I assembly.

scientific article published on June 1998

Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.

scholarly article

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

scientific article

Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA.

scientific article published on March 2004

HLA tapasin independence: broader peptide repertoire and HIV control

scientific article published on 23 October 2020

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC

scientific article published on 31 May 2019

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

scientific article published on 16 October 2019

Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition

scientific article published on 19 November 2015

Induction of protective antitumor immunity through attenuation of ERAAP function

scientific journal article

Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.

scientific article published on 12 March 2008

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

scientific article published on March 2003

MHC-restricted T cell responses against posttranslationally modified peptide antigens.

scientific article

Malaria systems immunology: Plasmodium vivax induces tolerance during primary infection through dysregulation of neutrophils and dendritic cells

scholarly article by Andrés F Vallejo et al published November 2018 in Journal of Infection

More images that yet fresh images Beget

scientific article published on 01 January 2009

Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.

scientific article published on 03 June 2013

Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions.

scientific article

Optimization of the MHC class I peptide cargo is dependent on tapasin

scientific article (publication date: April 2002)

Paper alert. Immunology

scientific article published on 01 April 2001

Peptide-independent stabilization of MHC class I molecules breaches cellular quality control

scientific article

Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function

scientific article published on 26 March 2015

Polymer microarrays: Identification of substrates for phagocytosis assays

scientific article published on 30 June 2006

Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens

scientific article published on 13 May 2011

Protein Plasticity and Peptide Editing in the MHC I Antigen Processing Pathway

scientific article published on 22 February 2018

Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection

scientific article published on 28 April 2017

Reply to Robinson and Brown: It is the combination of ERAP1 allotypes that identifies individuals with Ankylosing Spondylitis

scientific article published on 12 March 2015

Selector function of MHC I molecules is determined by protein plasticity

scientific article

Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells.

scientific article

Spatial modulation microscopy for real-time imaging of plasmonic nanoparticles and cells

scientific article published on 01 August 2012

Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis

scientific article

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

scientific article published in 2008

Synthesis and in vitro evaluation of alpha-GalCer epimers

scientific article published in July 2008

TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst

scientific article

TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

scientific article

Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility.

scientific article

Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.

scientific article published in February 2008

The 'chop-and-change' of MHC class I assembly

scientific article published on 01 January 2006

The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs

scientific article published on 6 January 2017

The cell biology of MHC class I antigen presentation.

scientific article

The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding.

scientific article published on October 2010

The complex route to MHC class I-peptide complexes.

scientific article published in October 2006

The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate

scientific article published on 14 February 2006

The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells.

scientific article

The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

scientific article published on 14 August 2018

The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules

scientific article

The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.

scientific article published on 29 March 2018

The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen

scientific article published on June 2012

The processing of antigens delivered as DNA vaccines.

scientific article published in June 2004

The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin

scientific article published on 01 December 2001

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

scientific article

Two polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteins

scientific article

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk.

scientific article

List of works by Tim Elliott

A Mechanistic Model for Predicting Cell Surface Presentation of Competing Peptides by MHC Class I Molecules

A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins.

A peptide filtering relation quantifies MHC class I peptide optimization

Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope

Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin

Assembly and export of MHC class I peptide ligands

Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function

Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses.

CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains.

Common variable immunodeficiency is associated with a functional deficiency of invariant natural killer T cells.

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

DNA Fusion Vaccine Designed to Induce Cytotoxic T Cell Responses Against Defined Peptide Motifs: Implications for Cancer Vaccines

DNA transfection screening from single beads.

Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens

Differential suppression of tumor-specific CD8+ T cells by regulatory T cells.

Direct deprotected glycosyl–asparagine ligation

Direct evidence for conformational dynamics in major histocompatibility complex class I molecules.

Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation

ERAP1 in the pathogenesis of ankylosing spondylitis.

ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity

Evidence for successive peptide binding and quality control stages during MHC class I assembly.

Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.

Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA.

HLA tapasin independence: broader peptide repertoire and HIV control

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition

Induction of protective antitumor immunity through attenuation of ERAAP function

Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.

Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.

MHC-restricted T cell responses against posttranslationally modified peptide antigens.

Malaria systems immunology: Plasmodium vivax induces tolerance during primary infection through dysregulation of neutrophils and dendritic cells

More images that yet fresh images Beget

Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.

Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions.

Optimization of the MHC class I peptide cargo is dependent on tapasin

Paper alert. Immunology

Peptide-independent stabilization of MHC class I molecules breaches cellular quality control

Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function

Polymer microarrays: Identification of substrates for phagocytosis assays

Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens

Protein Plasticity and Peptide Editing in the MHC I Antigen Processing Pathway

Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection

Reply to Robinson and Brown: It is the combination of ERAP1 allotypes that identifies individuals with Ankylosing Spondylitis

Selector function of MHC I molecules is determined by protein plasticity

Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells.

Spatial modulation microscopy for real-time imaging of plasmonic nanoparticles and cells

Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

Synthesis and in vitro evaluation of alpha-GalCer epimers

TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst

TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility.

Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.

The 'chop-and-change' of MHC class I assembly

The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs

The cell biology of MHC class I antigen presentation.

The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding.

The complex route to MHC class I-peptide complexes.

The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate

The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells.

The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules

The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.

The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen

The processing of antigens delivered as DNA vaccines.

The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

Two polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteins

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk.