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List of works by Lothar Rink

A new closed-tube multiplex real-time PCR to detect eleven superantigens of Streptococcus pyogenes identifies a strain without superantigen activity

scientific article published on 3 May 2007

A short 18 items food frequency questionnaire biochemically validated to estimate zinc status in humans

scientific article published on 21 February 2018

Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure.

scientific article published on 05 May 2016

Activation of IL-1β and TNFα genes is mediated by the establishment of permissive chromatin structures during monopoiesis ⬇️

scientific article published on October 26, 2012

Alterations in membrane fluidity are involved in inhibition of GM-CSF-induced signaling in myeloid cells by zinc

scientific article published on 02 May 2019

Altered cytokine production in the elderly.

scientific article published in May 1998

Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts

scientific article

Application of Zinpyr-1 for the investigation of zinc signals in Escherichia coli.

scientific article published on 17 January 2013

Assessment of gene-nutrient interactions on inflammatory status of the elderly with the use of a zinc diet score--ZINCAGE study

scientific article published on 15 May 2009

Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population

scientific article

B cell activation and proliferation increase intracellular zinc levels

scientific article published on 26 October 2018

Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio

scientific article published on 22 March 2006

Cadmium ions induce monocytic production of tumor necrosis factor-alpha by inhibiting mitogen activated protein kinase dephosphorylation

scientific article published on 23 June 2010

Cadmium ions promote monocytic differentiation of human leukemia HL-60 cells treated with 1α,25-dihydroxyvitamin D3.

scientific article published on November 2010

Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3.

scientific article published on 20 January 2010

Cellular zinc homeostasis modulates polarization of THP-1-derived macrophages

scientific article

Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis.

scientific article

Chelation of Free Zn²⁺ Impairs Chemotaxis, Phagocytosis, Oxidative Burst, Degranulation, and Cytokine Production by Neutrophil Granulocytes

scientific article published on 23 September 2015

Contrasting contributions of complementarity-determining region 2 and hypervariable region 4 of rat BV8S2+ (Vbeta8.2) TCR to the recognition of myelin basic protein and different types of bacterial superantigens

scientific article published on 29 March 2004

Correlation between zinc status and immune function in the elderly.

scientific article published on October 2006

Crosslinking of CD66B on peripheral blood neutrophils mediates the release of interleukin-8 from intracellular storage.

scientific article

Cytokine production and serum proteins in depression

scientific article published on 01 June 1995

Cytokine production of neutrophils is limited to interleukin-8

scientific article published on 01 December 1996

Dendritic cell subsets in lymph nodes are characterized by the specific draining area and influence the phenotype and fate of primed T cells

scientific article published on 20 November 2007

Development and validation of a ready to use cryo-EROD assay for the standardized screening of dioxins and dioxin-like compounds in foodstuffs

scientific article published on 06 October 2018

Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets.

scientific article

Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes

scientific article published in July 2014

Differential regulation of TLR-dependent MyD88 and TRIF signaling pathways by free zinc ions.

scientific article published on 17 July 2013

Differential synthesis of two interleukin-1 receptor antagonist variants and interleukin-8 by peripheral blood neutrophils.

scientific article

Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc

scientific article published on 07 March 2012

Dysregulation between TH1 and TH2 T cell subpopulations in the elderly

scientific article published on 01 June 1996

Editorial GMS special issue

scientific article published on 03 August 2018

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.

scientific article published in November 2015

Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals

scientific article published on 01 October 2006

Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles

scientific article

Effects of a short-term reduction in brain serotonin synthesis on the availability of the soluble leptin receptor in healthy women

scientific article published on 10 September 2014

Effects of human Toll-like receptor 1 polymorphisms on ageing.

scientific article published on 7 February 2013

Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects.

scientific article published in November 2007

Ethylmercury and Hg2+ induce the formation of neutrophil extracellular traps (NETs) by human neutrophil granulocytes.

scientific article published on 22 February 2015

Evidence for presence of IgG4 anti-immunoglobulin autoantibodies in all human beings

scientific article published on 01 May 2000

Experimental peri-implant mucositis around titanium and zirconia implants in comparison to a natural tooth: part 1-host-derived immunological parameters

scientific article published on 05 November 2018

Experimental peri-implant mucositis around titanium and zirconia implants in comparison to a natural tooth: part 2-clinical and microbiological parameters

scientific article published on 02 November 2018

Functional significance of zinc-related signaling pathways in immune cells.

scientific article published on January 2009

HLA-dependent heterogeneous T cell response to Mycoplasma arthritidis-derived superantigen (MAS)

scientific article published on 01 March 1997

Human neutrophils produce macrophage inhibitory protein-1beta but not type i interferons in response to viral stimulation

scientific article published on 01 April 2001

Hypothermia enhances the biological activity of lipopolysaccharide by altering its fluidity state

scientific article published on 01 September 1998

IFN-gamma reduction by tricyclic antidepressants.

scientific article

Immunosenescence of polymorphonuclear neutrophils.

scientific article

Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls

scientific article published on 8 March 2016

Impaired serum cortisol stress response is a predictor of early relapse.

scientific article published in March 2003

In situ hybridization of the mRNA for interferon-gamma, interferon-alpha E, interferon-beta, interleukin-1 beta and interleukin-6 and characterization of infiltrating cells in thyroid tissues

scientific article published on 01 April 1992

In vitro and in vivo effects of zinc on cytokine signalling in human T cells

scientific article published on 25 December 2007

Increased CD56+ natural killer cells and related cytokines in major depression

scientific article published on 01 January 1996

Induction of a cytokine network by superantigens with parallel TH1 and TH2 stimulation

scientific article published on 01 January 1996

Induction of a proinflammatory cytokine network by Mycoplasma arthritidis-derived superantigen (MAS)

scientific article published on 01 October 1996

Induction of interleukin-6 in murine bone marrow-derived macrophages stimulated by the Mycoplasma arthritidis mitogen MAS.

scientific article published in January 1990

Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration

scientific article

Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation

scientific article

Influence of DNA-methylation on zinc homeostasis in myeloid cells: Regulation of zinc transporters and zinc binding proteins.

scientific article published on 12 February 2016

Influence of zinc supplementation on immune parameters in weaned pigs.

scientific article published on 31 January 2018

Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass

scientific article published in July 2001

Interaction of zinc ions with human peripheral blood mononuclear cells

scientific article published on 01 August 1996

Interferon and lymphokine production by human placental and cord blood cells

scientific article published on 01 April 1992

Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.

scientific article

Lead ions abrogate lipopolysaccharide-induced nitric monoxide toxicity by reducing the expression of STAT1 and iNOS.

scientific article published on 19 April 2016

Leukocyte Counts Based on DNA Methylation at Individual Cytosines.

scientific article published on 8 November 2017

Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study

scientific article

Major depressive disorder is associated with elevated monocyte counts

scientific article published on 01 September 1996

Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study

scientific article published in January 2008

Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species ⬇️

scientific article published on October 14, 2010

Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival.

scientific article published on 27 November 2017

Metallothionein Downregulation in Very Old Age: A Phenomenon Associated with Cellular Senescence?

Microbial superantigens stimulate T cells by the superantigen bridge and independently by a cytokine pathway

scientific article published on 01 August 1997

Multiple impacts of zinc on immune function

scientific article published on July 2014

Mycoplasma arthritidis-derived superantigen (MAM) displays DNase activity.

scientific article published in March 2007

Neutrophil immunity of the elderly.

scientific article

No detectable effects of Acute Tryptophan Depletion on Short-Term Immune System Cytokine Levels in Healthy Adults.

scientific article published on 22 January 2018

One-way synergistic effect of low superantigen concentrations on lipopolysaccharide-induced cytokine production

scientific article published on 01 April 1997

PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation.

scientific article published on July 2014

Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators

scientific article published on 01 November 2006

Proton-pump inhibitors elevate infection rate in cardiothoracic surgery patients by influencing PMN function in vitro and in vivo.

scientific article published on 19 January 2018

Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation.

scientific article published on April 2014

Regulatory T cells increased while IL-1β decreased during antidepressant therapy

scientific article published on 21 April 2010

Repletion of zinc in zinc-deficient cells strongly up-regulates IL-1β-induced IL-2 production in T-cells.

scientific article

Superantigen genes are more important than the emm type for the invasiveness of group A Streptococcus infection.

scientific article published in July 2010

Superantigen-presentation by rat major histocompatibility complex class II molecules RT1.Bl and RT1.Dl

scientific article published on 24 December 2008

Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression

scholarly article by Peter Uciechowski et al published 3 June 2011 in Journal of Leukocyte Biology

T-helper type 1 cytokine release is enhanced by in vitro zinc supplementation due to increased natural killer cells

scientific article published on 05 December 2006

TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation

scientific article published on 28 November 2007

The Interaction of Sodium and Zinc in the Priming of T Cell Subpopulations Regarding Th17 and Treg Cells

scientific article published on 07 January 2020

The Intracellular Free Zinc Level Is Vital for Treg Function and a Feasible Tool to Discriminate between Treg and Activated Th Cells

scholarly article by Martina Maywald published in November 2018

The Th17/Treg balance is disturbed during aging.

scientific article published on 20 September 2013

The biochemical effects of extracellular Zn(2+) and other metal ions are severely affected by their speciation in cell culture media.

scientific article

The consumption of cigarettes, coffee and sweets in detoxified alcoholics and its association with relapse and a family history of alcoholism

scientific article published in August 2005

The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects

scientific article published on 27 November 2018

The immunobiology of zinc ⬇️

scientific article published on November 1, 1997

The impaired immune response to diphtheria vaccination in elderly chronic hemodialysis patients is related to zinc deficiency

scientific article published on 01 January 2000

The influence of naturally occurring heterophilic anti-immunoglobulin antibodies on direct measurement of serum proteins using sandwich ELISAs

scientific article published on 01 February 2000

The role of zinc in calprotectin expression in human myeloid cells

scientific article published on 23 April 2018

The superantigen staphylococcal enterotoxin A (SEA) and monoclonal antibody L243 share a common epitope but differ in their ability to induce apoptosis via MHC-II.

scientific article published on 3 July 2006

The superantigen-induced polarization of T cells in rat peripheral lymph nodes is influenced by genetic polymorphisms in the IL-4 and IL-6 gene clusters

scientific article published on 27 November 2006

UK food standards agency workshop report: diet and immune function

scientific article published on 9 March 2010

Use of molecular indicators of inflammation to assess the biocompatibility of all-ceramic restorations

scientific article published on 30 December 2015

Zinc Signals and Immunity

scientific article published on 24 October 2017

Zinc and ageing (ZINCAGE Project)

scientific article published on 01 October 2006

Zinc and the immune system

scientific article

Zinc as a Gatekeeper of Immune Function.

scientific article published on 25 November 2017

Zinc as a micronutrient and its preventive role of oxidative damage in cells.

scientific article published on 19 August 2015

Zinc chelation decreases IFN-β-induced STAT1 upregulation and iNOS expression in RAW 264.7 macrophages

scientific article

Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study.

scientific article

Zinc deficiency drives Th17 polarization and promotes loss of Treg cell function

scientific article published on 21 September 2018

Zinc deficiency induces production of the proinflammatory cytokines IL-1β and TNFα in promyeloid cells via epigenetic and redox-dependent mechanisms.

scientific article

Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.

scientific article published on 20 November 2015

Zinc homeostasis and immunity

scientific article published on 28 November 2006

Zinc homeostasis and immunosenescence.

scientific article published on 13 June 2014

Zinc homeostasis in aging: two elusive faces of the same "metal".

scientific article published in January 2006

Zinc in Infection and Inflammation

scientific article

Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response

scientific article published in June 2004

Zinc inhibits interleukin‐1‐dependent T cell stimulation ⬇️

scientific article published on October 1, 1997

Zinc signals in neutrophil granulocytes are required for the formation of neutrophil extracellular traps

scientific article published on 24 September 2012

Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study

scientific article published in October 2006

Zinc supplementation augments TGF-β1-dependent regulatory T cell induction

scientific article published on 29 October 2016

Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions

scientific article published on 01 February 2008

Zinc supplementation induces CD4CD25Foxp3 antigen-specific regulatory T cells and suppresses IFN-γ production by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1

article

Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures.

scientific article published on 28 November 2015

Zinc supplementation plays a crucial role in T helper 9 differentiation in allogeneic immune reactions and non-activated T cells

scientific article published on 6 February 2018

Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons

scientific article published on 01 August 1997

Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study.

scientific article

Zn-net special issue

scientific article published on 27 April 2018

[The immune system in aging]

scientific article published on 01 December 2001

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