List of works - Patrick Chames

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy. ⬇️

scientific article

A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3.

scientific article published on 10 November 2004

A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells

scientific article

Affinity Determination of Biotinylated Antibodies by Flow Cytometry

scientific article published on 01 January 2012

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.

scientific article published on 6 December 2017

Anti-Mesothelin Nanobodies for Both Conventional and Nanoparticle-Based Biomedical Applications

scientific article published on July 2015

Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

scientific article

Conformational nanobodies reveal tethered epidermal growth factor receptor involved in EGFR/ErbB2 predimers

scientific article

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

article

Detection of carcinoembryonic antigen using single-domain or full-size antibodies stained with quantum dot conjugates.

scientific article

Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library.

scientific article published in July 2000

Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity.

scientific article

Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies.

scientific article

Engineering of an Anti-Steroid Antibody: Amino Acid Substitutions Change Antibody Fine Specificity from Cortisol Estradiol ⬇️

scholarly article by P Chames & D Baty published June 1998 in Clinical Chemistry and Laboratory Medicine

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

scientific article

Fragments d’anticorps à domaine unique

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR.

scientific article published in August 2000

Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells

scientific article

In vivo detection of small tumour lesions by multi-pinhole SPECT applying a (99m)Tc-labelled nanobody targeting the Epidermal Growth Factor Receptor.

scientific article

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.

scientific article published on 3 February 2011

Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cells

scientific article

Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalyti

scientific article published on 01 June 2002

Isolation of human antibodies to tumor-associated endothelial cell markers by in vitro human endothelial cell selection with phage display libraries.

scientific article

Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen.

scientific article

Masked selection: a straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display

scientific article published on 20 December 2013

Multiphoton imaging of tumor biomarkers with conjugates of single-domain antibodies and quantum dots.

scientific article

Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer

scientific article published on 21 January 2019

Optimizing the exogenous antigen loading of monocyte-derived dendritic cells

scientific article published on 11 April 2005

Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes

scientific article

Phage display and selections on cells.

scientific article

Polymerase chain reaction-based site-directed mutagenesis using magnetic beads.

scientific article published on February 1996

Production of a soluble and active MBP-scFv fusion: favorable effect of the leaky tolR strain

article

Selection of human antibody fragments directed against tumor T-cell epitopes for adoptive T-cell therapy

scientific article

Selection of intracellular single-domain antibodies targeting the HIV-1 Vpr protein by cytoplasmic yeast two-hybrid system.

scientific article

Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays.

scientific article published on 20 May 2009

Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots.

scientific article published on 15 March 2018

Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches ⬇️

scientific article published on July 6, 2012

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions

scientific article published on 15 February 2012

Special Issue: Nanobody

scientific article published on 06 March 2020

State of the art in tumor antigen and biomarker discovery.

scientific article published on 09 June 2011

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120.

scientific article published on 13 September 2012

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120

scientific article published on 14 November 2012

Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation

scientific article

Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization

scientific article published on 13 September 2012

T cell retargeting with MHC class I-restricted antibodies: the CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production

scientific article published in June 2005

TCR-like human antibodies expressed on human CTLs mediate antibody affinity-dependent cytolytic activity.

scientific article

Therapeutic antibodies for the treatment of pancreatic cancer.

scientific article published on 15 June 2010

Therapeutic antibodies: successes, limitations and hopes for the future

scientific article published on May 2009

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

scientific article published on 07 February 2022

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1

scientific article published on 21 September 2015

List of works by Patrick Chames

A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy. ⬇️

A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3.

A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells

Affinity Determination of Biotinylated Antibodies by Flow Cytometry

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.

Anti-Mesothelin Nanobodies for Both Conventional and Nanoparticle-Based Biomedical Applications

Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

Conformational nanobodies reveal tethered epidermal growth factor receptor involved in EGFR/ErbB2 predimers

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

Detection of carcinoembryonic antigen using single-domain or full-size antibodies stained with quantum dot conjugates.

Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library.

Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity.

Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies.

Engineering of an Anti-Steroid Antibody: Amino Acid Substitutions Change Antibody Fine Specificity from Cortisol Estradiol ⬇️

Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets

Fragments d’anticorps à domaine unique

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR.

Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells

In vivo detection of small tumour lesions by multi-pinhole SPECT applying a (99m)Tc-labelled nanobody targeting the Epidermal Growth Factor Receptor.

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.

Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cells

Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalyti

Isolation of human antibodies to tumor-associated endothelial cell markers by in vitro human endothelial cell selection with phage display libraries.

Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen.

Masked selection: a straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display

Multiphoton imaging of tumor biomarkers with conjugates of single-domain antibodies and quantum dots.

Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer

Optimizing the exogenous antigen loading of monocyte-derived dendritic cells

Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes

Phage display and selections on cells.

Polymerase chain reaction-based site-directed mutagenesis using magnetic beads.

Production of a soluble and active MBP-scFv fusion: favorable effect of the leaky tolR strain

Selection of human antibody fragments directed against tumor T-cell epitopes for adoptive T-cell therapy

Selection of intracellular single-domain antibodies targeting the HIV-1 Vpr protein by cytoplasmic yeast two-hybrid system.

Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays.

Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots.

Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches ⬇️

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions

Special Issue: Nanobody

State of the art in tumor antigen and biomarker discovery.

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120.

Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120

Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation

Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization

T cell retargeting with MHC class I-restricted antibodies: the CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production

TCR-like human antibodies expressed on human CTLs mediate antibody affinity-dependent cytolytic activity.

Therapeutic antibodies for the treatment of pancreatic cancer.

Therapeutic antibodies: successes, limitations and hopes for the future

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1