List of works - Hirokazu Okayama

A subset of patients with MSS/MSI-low-colorectal cancer showed increased CD8(+) TILs together with up-regulated IFN-γ

scientific article published on 02 October 2019

Aberrant glycosylation in colorectal cancer with genomic and epigenomic alterations

An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers

scientific article published in July 2015

Augmentation of antibody-dependent cellular cytotoxicity with defucosylated monoclonal antibodies in patients with GI-tract cancer

scientific article published on 8 December 2017

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer.

scientific article

CDX2 is involved in microRNA-associated inflammatory carcinogenesis in gastric cancer

scientific article published on 15 September 2017

Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers

scientific article published on 26 November 2019

Combination of protein coding and noncoding gene expression as a robust prognostic classifier in stage I lung adenocarcinoma.

scientific article published on 2 May 2013

Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma.

scientific article published on 3 February 2012

Curative Surgery for Advanced Gastric Cancer with Extensive Lymph Node Metastasis after Long-Term Chemotherapy

scientific article published in November 2015

Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.

scientific article published on 11 April 2014

Ectopic expression of MECA-79 as a novel prognostic indicator in gastric cancer.

scientific article

Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma.

scientific article

Expression of circadian clock genes in human colorectal adenoma and carcinoma

scientific article published on 4 September 2017

Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis

scientific article published on 29 May 2018

High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer

scientific article

Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer

scientific article

Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas

scientific article published on 11 November 2011

Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma

scientific article published on 14 November 2017

Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer

scientific article

Intraperitoneal chemotherapy for gastric cancer with peritoneal disease: experience from Singapore and Japan.

scientific article

KIF5B-RET fusions in lung adenocarcinoma.

scientific article published on 12 February 2012

KRT17 as a prognostic biomarker for stage II colorectal cancer

scientific article published on 22 November 2019

L-type amino acid transporter 1 expression is upregulated and associated with cellular proliferation in colorectal cancer

scientific article published on 6 October 2017

MicroRNAs and inflammation in the pathogenesis and progression of colon cancer.

scientific article

Microanatomy of inferior mesenteric artery sheath in colorectal cancer surgery

scientific article published on 30 October 2019

NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression

scientific article

Overexpression of endoglin (CD105) is associated with recurrence in radically resected gastric cancer.

scientific article published on July 2010

PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer.

scientific article published on 16 October 2017

Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer.

scientific article published on 10 April 2019

Possible involvement of LKB1-AMPK signaling in non-homologous end joining

scientific article published on 15 April 2013

Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells

scientific article published on 14 July 2018

Prognostic role of ARID1A negative expression in gastric cancer

scientific article published on 01 May 2019

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer

scientific article published in PLoS ONE

Regulation of PD-L1 by MicroRNA in Mismatch Repair Deficient-Colorectal Cancer

scientific article published in October 2017

Serum transthyretin level is associated with prognosis of patients with gastric cancer

scientific article published on 15 March 2018

Stromal VCAN expression as a potential prognostic biomarker for disease recurrence in stage II-III colon cancer

scientific article

TSPAN2 is involved in cell invasion and motility during lung cancer progression.

scientific article published on 13 April 2014

The expression of four genes as a prognostic classifier for stage I lung adenocarcinoma in 12 independent cohorts

scientific article

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer

scientific article published on 29 November 2020

Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammation, and Angiogenesis ⬇️

scientific article published on 27 August 2019

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer ⬇️

scientific article published on September 27, 2012

Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis.

scientific article published on 20 January 2011

[A case of hepatic metastases of sigmoid colon cancer which completely responded to systemic l-leucovorin/5-FU therapy and oral LV/UFT combination therapy]

scientific article published on 01 May 2006

miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1

scientific article published on 14 March 2019

List of works by Hirokazu Okayama

A subset of patients with MSS/MSI-low-colorectal cancer showed increased CD8(+) TILs together with up-regulated IFN-γ

Aberrant glycosylation in colorectal cancer with genomic and epigenomic alterations

An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers

Augmentation of antibody-dependent cellular cytotoxicity with defucosylated monoclonal antibodies in patients with GI-tract cancer

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer.

CDX2 is involved in microRNA-associated inflammatory carcinogenesis in gastric cancer

Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers

Combination of protein coding and noncoding gene expression as a robust prognostic classifier in stage I lung adenocarcinoma.

Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma.

Curative Surgery for Advanced Gastric Cancer with Extensive Lymph Node Metastasis after Long-Term Chemotherapy

Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.

Ectopic expression of MECA-79 as a novel prognostic indicator in gastric cancer.

Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma.

Expression of circadian clock genes in human colorectal adenoma and carcinoma

Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis

High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer

Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer

Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas

Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma

Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer

Intraperitoneal chemotherapy for gastric cancer with peritoneal disease: experience from Singapore and Japan.

KIF5B-RET fusions in lung adenocarcinoma.

KRT17 as a prognostic biomarker for stage II colorectal cancer

L-type amino acid transporter 1 expression is upregulated and associated with cellular proliferation in colorectal cancer

MicroRNAs and inflammation in the pathogenesis and progression of colon cancer.

Microanatomy of inferior mesenteric artery sheath in colorectal cancer surgery

NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression

Overexpression of endoglin (CD105) is associated with recurrence in radically resected gastric cancer.

PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer.

Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer.

Possible involvement of LKB1-AMPK signaling in non-homologous end joining

Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells

Prognostic role of ARID1A negative expression in gastric cancer

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer

Regulation of PD-L1 by MicroRNA in Mismatch Repair Deficient-Colorectal Cancer

Serum transthyretin level is associated with prognosis of patients with gastric cancer

Stromal VCAN expression as a potential prognostic biomarker for disease recurrence in stage II-III colon cancer

TSPAN2 is involved in cell invasion and motility during lung cancer progression.

The expression of four genes as a prognostic classifier for stage I lung adenocarcinoma in 12 independent cohorts

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer

Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammation, and Angiogenesis ⬇️

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer ⬇️

Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis.

[A case of hepatic metastases of sigmoid colon cancer which completely responded to systemic l-leucovorin/5-FU therapy and oral LV/UFT combination therapy]

miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1