Search filters

List of works by Jonathan M Elkins

A device for the high-pressure oxygenation of protein crystals

article

Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction

scientific article

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

scientific article published on 26 January 2018

Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria

scientific article

Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.

scientific article

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

scientific article published on 11 November 2019

Case study--structural genomics and human protein kinases.

scientific article published in January 2014

Comprehensive characterization of the Published Kinase Inhibitor Set

scientific article

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

scientific article published on 29 August 2016

Crystal Structure of Human Aurora B in Complex with INCENP and VX-680

scientific article

Crystal Structure of Sphingosine Kinase 1 with PF-543

scientific article published on 27 October 2014

Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class

scientific article

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway

scientific article

Crystal structure of human RIOK2 bound to a specific inhibitor

scientific article published on 01 April 2019

Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue

scientific article

Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships

scientific article published on 26 November 2019

Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14.

scientific article published on 9 October 2017

Donated chemical probes for open science

scientific article published on 20 April 2018

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases

scientific article published on 29 January 2016

Fragment screening of cyclin G-associated kinase by weak affinity chromatography

scientific article

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions

scientific article published on 23 September 2013

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

scientific journal article

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.

scientific article

Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors

scientific article

NMR assignment of human RGS18.

scientific article published on 9 September 2006

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis

scientific article

Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles

scientific article

Progress towards a public chemogenomic set for protein kinases and a call for contributions

scientific article

Resonance assignment of the RGS domain of human RGS10

scientific article published on 19 December 2006

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

scientific journal article

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

scientific article

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in

scientific article published on 04 April 2019

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

scientific article

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

scientific article published in Scientific Reports

Structural basis for protein-protein interactions in the 14-3-3 protein family

scholarly article

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

scientific article published on 29 October 2013

Structural insights into the activation of MST3 by MO25

scientific article

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

scientific article published on 18 July 2019

Structure of dystrophia myotonica protein kinase

scientific article

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

scientific article

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

scientific article

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

scientific article published on 6 October 2017

The Intersection of Structural and Chemical Biology - An Essential Synergy

scientific article

The Structure of the Full-Length Tetrameric PKA Regulatory RII Complex Reveals the Mechanism of Allosteric PKA Activation

scientific article published on 8 May 2012

The centaurin gamma-1 GTPase-like domain functions as an NTPase

scientific article published in February 2007

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex

scientific journal article

Type II Inhibitors Targeting CDK2

scientific article

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

scientific article

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

scientific article

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster

scientific article

Paulina is supported by:

About Paulina

Help