List of works - Thomas Coates

A microcomputer-based program for video analysis of chemotaxis under agarose

scientific article published on 01 December 1985

A practical approach to neutrophil disorders.

scientific article

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease.

scientific article

A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing

scientific article

ADP-ribosylation of Rho enhances actin polymerization-coupled shape oscillations in human neutrophils

scientific article published on 01 September 1995

Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia.

scientific article

An integrated system for quantitation of chemotaxis using a 48-well millipore filter assay

scientific article published in July 1992

Analysis of multi-parameter video measurements of human neutrophil movement and its relation to cell shape and cytosolic calcium

scientific article

Anemia predicts lower white matter volume and cognitive performance in sickle and non-sickle cell anemia syndrome

scientific article published on 23 July 2019

Angiomatoid malignant fibrous histiocytoma with extensive lymphadenopathy simulating Castleman's disease.

scientific article published on January 1986

Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major

scientific article

Aura and mental stress are associated with reports of pain in sickle cell disease-a pilot study using a mobile application

scientific article published on 19 January 2020

Bad liver and a broken heart

scientific article published on 01 March 2014

Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy.

scientific article

Cardiac iron overload in sickle-cell disease

scientific article

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease.

scientific article published on 2 June 2015

Cobalamin C disease presenting with hemophagocytic lymphohistiocytosis

scientific article

Combining two orally active iron chelators for thalassemia.

scientific article published on 10 March 2010

Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron

scientific article published on 06 February 2013

Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review.

scientific article published on October 2007

Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective.

scientific article published on January 2007

Design of the silent cerebral infarct transfusion (SIT) trial.

scientific article published on March 2010

Determinants of resting cerebral blood flow in sickle cell disease

scientific article published on 6 June 2016

Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI.

scientific article published in December 2017

Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia.

scientific article

Electrocardiographic consequences of cardiac iron overload in thalassemia major.

scientific article published on 4 November 2011

Exercise performance in thalassemia major: correlation with cardiac iron burden.

scientific article published on 22 January 2013

Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload.

scientific article published on 28 February 2014

Fixing the MRI R2-iron calibration in liver

scientific article published on 12 February 2020

Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial

scientific article published on October 2010

Function of the cytoskeleton in human neutrophils and methods for evaluation

scientific article

Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients

scientific article published on 12 March 2013

Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study

scientific article published on 25 July 2018

Increased leucocyte apoptosis in transfused β‐thalassaemia patients ⬇️

scientific article published on December 6, 2012

Increased neutrophil respiratory burst in bcr-null mutants

scientific journal article

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain.

scientific article

Inhibition of production of LTB4 and chemotactic agent from rat alveolar macrophages treated with t-butyl hydroperoxide is independent of ATP depletion.

scientific article published on June 1990

Introduction to a How I Treat series on sickle cell disease and thalassemia

scientific article published on 11 September 2018

Introduction to a review series on human neutrophils

scientific article published on 21 March 2019

Iron chelation in thalassemia: time to reconsider our comfort zones.

scientific article published on February 2011

Iron toxicity and its possible association with treatment of Cancer: lessons from hemoglobinopathies and rare, transfusion-dependent anemias.

scientific article

Is it time to SWiTCH to composite primary endpoints?

scientific article

Kidney iron deposition by R2* is associated with haemolysis and urinary iron

scientific article published on 20 November 2020

Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease

scientific article

Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion

scientific article published on 28 November 2020

Low‐shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy ⬇️

scientific article published on August 6, 2012

MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients

scientific article published on 28 April 2005

MRI detects myocardial iron in the human heart.

scientific article

Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis.

scientific article published on September 2008

Magnetic resonance imaging of lymphomas in children

scientific article published on 01 January 1985

Management of iron overload in hemoglobinopathies: what is the appropriate target iron level?

scientific article published on March 2016

Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells.

scientific article published on July 1994

Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens.

scientific article

Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease

scientific article published on 20 November 2003

Nocturnal peripheral vasoconstriction predicts the frequency of severe acute pain episodes in children with sickle cell disease

scientific article published on 07 October 2020

Nutritional deficiencies in iron overloaded patients with hemoglobinopathies

scientific article

Onset of cardiac iron loading in pediatric patients with thalassemia major.

scientific article published on 15 April 2008

Outcomes, utilization, and costs among thalassemia and sickle cell disease patients receiving deferoxamine therapy in the United States.

scientific article published in April 2008

Pain as an emergent issue in thalassemia

scientific article published in May 2010

Pancreatic iron and glucose dysregulation in thalassemia major

scientific article published on 24 November 2011

Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major

scientific article published on 01 December 2010

Pancreatic iron loading predicts cardiac iron loading in thalassemia major.

scientific article published on 02 September 2009

Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial

scientific article

Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion.

scientific article

Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease.

scientific article

Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease.

scientific article

Physiology and pathophysiology of iron in hemoglobin-associated diseases.

scientific article published on 12 April 2014

Pituitary iron and volume imaging in healthy controls.

scientific article published on 11 November 2011

Pituitary iron and volume predict hypogonadism in transfusional iron overload

scientific article

Placenta growth factor activates monocytes and correlates with sickle cell disease severity ⬇️

scientific article published on April 24, 2003

Population based surveillance in sickle cell disease: methods, findings and implications from the California registry and surveillance system in hemoglobinopathies project (RuSH).

scientific article published on 30 August 2014

Prediabetes, elevated iron and all-cause mortality: a cohort study

scientific article

Predicting pituitary iron and endocrine dysfunction

scientific article published in August 2010

Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia

scientific article published on 01 May 2007

Pulmonary function in thalassaemia major and its correlation with body iron stores

scientific article

Pulmonary hypertension does not affect the autonomic nervous system dysfunction of sickle cell disease

scholarly article by Jocelyn Inamo et al published May 2009 in American Journal of Hematology

Pulmonary hypertension in well-transfused thalassemia major patients

scientific article

Qualitative functional deficiency of affinity-purified lactoferrin from neutrophils of patients with chronic myelogenous leukemia, and lactoferrin/H-ferritin-cell interactions in a patient with lactoferrin-deficiency with normal numbers of circulati

scientific article published on 01 January 1991

Quantitative analysis and modelling of hepatic iron stores using stereology and spatial statistics.

scientific article published in June 2010

Quantitative computed tomography assessment of transfusional iron overload.

scientific article published on 22 April 2011

Revisiting the relationship between vitamin D deficiency, cardiac iron and cardiac function in thalassemia major

scientific article published on 22 December 2010

Role of Selenium-Dependent Glutathione Peroxidase in Antioxidant Defenses in Rat Alveolar Macrophages

scientific article published in January 1988

Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome

scientific article published in May 2004

Secretory phospholipase A2 levels in patients with sickle cell disease and acute chest syndrome

scientific article published on 01 January 2006

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury

scientific article published on 31 August 2009

Shape oscillations: a fundamental response of human neutrophils stimulated by chemotactic peptides?

scientific article published on 01 February 1995

Sickle cell disease in California: sociodemographic predictors of emergency department utilization

scientific article published on 25 February 2011

Sickle cell disease: selected aspects of pathophysiology.

scientific article

Sickle cell microvascular paradox-oxygen supply-demand mismatch

scientific article published on 19 April 2019

Sickle‐cell disease in California: A population‐based description of emergency department utilization ⬇️

scientific article published on November 24, 2010

So what if blood is thicker than water?

scientific article published on 01 January 2011

Spectral imaging microscopy web sites and data

scientific article

Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major.

scientific article

Systematic review of transition from adolescent to adult care in patients with sickle cell disease.

scientific article

The impact of chelation therapy on survival in transfusional iron overload: a meta-analysis of myelodysplastic syndrome.

scientific article published on 22 July 2014

Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia.

scientific article

Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age.

scientific article published on 2 September 2013

Tricuspid regurgitant jet velocity and myocardial tissue doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups - revisiting this controversial concept after sixteen years of

scientific article published on 17 September 2020

Variance of pain prevalence and associated severity during the transfusion cycle of adult thalassaemia patients

scientific article

Vaso-Occlusion in Sickle Cell Disease: Is Autonomic Dysregulation of the Microvasculature the Trigger?

scientific article published on 15 October 2019

White matter has impaired resting oxygen delivery in sickle cell patients

scientific article published on 21 February 2019

You don't always get what you want: Does hypoxia cause sickle cell crisis?

scientific article

β-globin gene transfer to human bone marrow for sickle cell disease.

scientific article

List of works by Thomas Coates

A microcomputer-based program for video analysis of chemotaxis under agarose

A practical approach to neutrophil disorders.

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease.

A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing

ADP-ribosylation of Rho enhances actin polymerization-coupled shape oscillations in human neutrophils

Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia.

An integrated system for quantitation of chemotaxis using a 48-well millipore filter assay

Analysis of multi-parameter video measurements of human neutrophil movement and its relation to cell shape and cytosolic calcium

Anemia predicts lower white matter volume and cognitive performance in sickle and non-sickle cell anemia syndrome

Angiomatoid malignant fibrous histiocytoma with extensive lymphadenopathy simulating Castleman's disease.

Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major

Aura and mental stress are associated with reports of pain in sickle cell disease-a pilot study using a mobile application

Bad liver and a broken heart

Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy.

Cardiac iron overload in sickle-cell disease

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease.

Cobalamin C disease presenting with hemophagocytic lymphohistiocytosis

Combining two orally active iron chelators for thalassemia.

Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron

Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review.

Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective.

Design of the silent cerebral infarct transfusion (SIT) trial.

Determinants of resting cerebral blood flow in sickle cell disease

Diminished cerebral oxygen extraction and metabolic rate in sickle cell disease using T2 relaxation under spin tagging MRI.

Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia.

Electrocardiographic consequences of cardiac iron overload in thalassemia major.

Exercise performance in thalassemia major: correlation with cardiac iron burden.

Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload.

Fixing the MRI R2-iron calibration in liver

Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial

Function of the cytoskeleton in human neutrophils and methods for evaluation

Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients

Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study

Increased leucocyte apoptosis in transfused β‐thalassaemia patients ⬇️

Increased neutrophil respiratory burst in bcr-null mutants

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain.

Inhibition of production of LTB4 and chemotactic agent from rat alveolar macrophages treated with t-butyl hydroperoxide is independent of ATP depletion.

Introduction to a How I Treat series on sickle cell disease and thalassemia

Introduction to a review series on human neutrophils

Iron chelation in thalassemia: time to reconsider our comfort zones.

Iron toxicity and its possible association with treatment of Cancer: lessons from hemoglobinopathies and rare, transfusion-dependent anemias.

Is it time to SWiTCH to composite primary endpoints?

Kidney iron deposition by R2* is associated with haemolysis and urinary iron

Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease

Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion

Low‐shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy ⬇️

MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients

MRI detects myocardial iron in the human heart.

Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis.

Magnetic resonance imaging of lymphomas in children

Management of iron overload in hemoglobinopathies: what is the appropriate target iron level?

Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells.

Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens.

Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease

Nocturnal peripheral vasoconstriction predicts the frequency of severe acute pain episodes in children with sickle cell disease

Nutritional deficiencies in iron overloaded patients with hemoglobinopathies

Onset of cardiac iron loading in pediatric patients with thalassemia major.

Outcomes, utilization, and costs among thalassemia and sickle cell disease patients receiving deferoxamine therapy in the United States.

Pain as an emergent issue in thalassemia

Pancreatic iron and glucose dysregulation in thalassemia major

Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major

Pancreatic iron loading predicts cardiac iron loading in thalassemia major.

Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial

Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion.

Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease.

Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease.

Physiology and pathophysiology of iron in hemoglobin-associated diseases.

Pituitary iron and volume imaging in healthy controls.

Pituitary iron and volume predict hypogonadism in transfusional iron overload

Placenta growth factor activates monocytes and correlates with sickle cell disease severity ⬇️

Population based surveillance in sickle cell disease: methods, findings and implications from the California registry and surveillance system in hemoglobinopathies project (RuSH).

Prediabetes, elevated iron and all-cause mortality: a cohort study

Predicting pituitary iron and endocrine dysfunction

Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia

Pulmonary function in thalassaemia major and its correlation with body iron stores

Pulmonary hypertension does not affect the autonomic nervous system dysfunction of sickle cell disease

Pulmonary hypertension in well-transfused thalassemia major patients

Qualitative functional deficiency of affinity-purified lactoferrin from neutrophils of patients with chronic myelogenous leukemia, and lactoferrin/H-ferritin-cell interactions in a patient with lactoferrin-deficiency with normal numbers of circulati

Quantitative analysis and modelling of hepatic iron stores using stereology and spatial statistics.