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List of works by Nancy P Keller

A Bcl-2 Associated Athanogene (bagA) Modulates Sexual Development and Secondary Metabolism in the Filamentous Fungus Aspergillus nidulans.

scientific article

A Cationic Polymer That Shows High Antifungal Activity against Diverse Human Pathogens

scientific article published on 24 July 2017

A Cellular Fusion Cascade Regulated by LaeA Is Required for Sclerotial Development in Aspergillus flavus

scientific article published on 5 October 2017

A LaeA- and BrlA-dependent cellular network governs tissue-specific secondary metabolism in the human pathogen Aspergillus fumigatus

A Volatile Relationship: Profiling an Inter-Kingdom Dialogue Between two Plant Pathogens, Ralstonia Solanacearum and Aspergillus Flavus

article

A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans

scientific article published on 17 October 2007

A broadly conserved fungal alcohol oxidase (<scp>AOX</scp>) facilitates fungal invasion of plants

scientific article published in 2022

A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen

scientific article published on 04 April 2019

A circadian oscillator in Aspergillus spp. regulates daily development and gene expression

scientific article

A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici ⬇️

scientific article

A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans ⬇️

scientific article published on March 2009

A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus ⬇️

scientific article published on February 2013

A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine.

scientific article published on 26 March 2013

A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus

scientific article published on 01 January 2018

A scalable platform to identify fungal secondary metabolites and their gene clusters ⬇️

scientific article published on 12 June 2017

Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA

article

An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR ⬇️

scientific article published on February 10, 2012

An Interpreted Atlas of Biosynthetic Gene Clusters from 1000 Fungal Genomes

preprint of a scholarly article

An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus

scientific article published on 14 March 2018

An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes

scholarly article

Anaerobic gut fungi are an untapped reservoir of natural products

scientific article published in 2021

Analysis of the Relationship between Alternative Respiration and Sterigmatocystin Formation in Aspergillus nidulans.

scientific article published on 20 April 2018

Apple Intrinsic Factors Modulating the Global Regulator, LaeA, the Patulin Gene Cluster and Patulin Accumulation During Fruit Colonization by Penicillium expansum

scientific article published on 27 July 2018

Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence.

scientific article published on August 2005

Aspergillus flavus ⬇️

scientific article published on January 1, 2011

Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer

scientific article published on 16 November 2009

Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors

scientific article published on 18 September 2012

Bacterial-fungal interactions revealed by genome-wide analysis of bacterial mutant fitness

scientific article published on 02 November 2020

Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters

scientific article published on March 2010

Blistering1 Modulates Penicillium expansum Virulence Via Vesicle-mediated Protein Secretion

scientific article published on 23 December 2019

Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus

scientific article published on 23 February 2017

Characterization and Biosynthesis of a Rare Fungal Hopane-Type Triterpenoid Glycoside Involved in the Antistress Property of Aspergillus fumigatus

scientific article published on 12 April 2019

Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station

scientific article (publication date: 26 October 2016)

Characterization of the Aspergillus nidulans monodictyphenone gene cluster. ⬇️

scientific article

Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction

scientific article published in September 2004

Characterization of the Far Transcription Factor Family in Aspergillus flavus.

scientific article published on 17 August 2016

Chromatin-level regulation of biosynthetic gene clusters

scientific article published on July 2009

Co-opting oxylipin signals in microbial disease

scientific article published on 01 June 2019

Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus

scientific article

CoIN: co-inducible nitrate expression system for secondary metabolites in Aspergillus nidulans

scientific article published on 13 March 2018

Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi.

scientific article published on 22 May 2018

Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

article

Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains

scientific article published on 18 February 2020

Copper Utilization, Regulation, and Acquisition by

scientific article published on 23 April 2019

Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi ⬇️

Correlation of nitric oxide produced by an inducible nitric oxide synthase-like protein with enhanced expression of the phenylpropanoid pathway in Inonotus obliquus cocultured with Phellinus morii

scientific article

Cryptic Aspergillus nidulans antimicrobials.

scientific article

Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish

scientific article published on 25 March 2022

Defects in conidiophore development and conidium-macrophage interactions in a dioxygenase mutant of Aspergillus fumigatus.

scientific article published on 28 April 2008

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

scientific article published on 01 July 2018

Depsipeptide Aspergillicins Revealed by Chromatin Reader Protein Deletion

scientific article published on 24 May 2019

Diketopiperazine Formation in Fungi Requires Dedicated Cyclization and Thiolation Domains

scientific article published on 28 August 2019

Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae.

scientific article

Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus

scientific article published in May 2009

Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates

scientific article published on 08 April 2020

Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

scientific article

Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

article

Efficacy of Voriconazole against Aspergillus fumigatus Infection Depends on Host Immune Function

scientific article published on 27 January 2020

Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans

scientific article published on 18 May 2009

Endogenous lipogenic regulators of spore balance in Aspergillus nidulans

scientific article

Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi

scientific article published on January 2016

Erratum: Corrigendum: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

scientific article published in Nature

Establishing a Biofilm Co-culture of Pseudomonas and Aspergillus for Metabolite Extraction

scientific article

Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products

scientific article

Fast and Easy Method for Construction of Plasmid Vectors Using Modified Quick-Change Mutagenesis ⬇️

scientific article published on January 1, 2012

FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence

scientific article

FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection

scientific article (publication date: April 2016)

Functional Analyses ofTrichoderma reeseiLAE1 Reveal Conserved and Contrasting Roles of This Regulator ⬇️

scientific article published on February 1, 2013

Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans

scientific article published on 08 April 2020

Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta

scientific article published in August 2005

Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus. ⬇️

scientific article published on 29 May 2018

Fungal artificial chromosomes for mining of the fungal secondary metabolome

scientific article published on 29 April 2015

Fungal attack and host defence pathways unveiled in near-avirulent interactions of Penicillium expansum creA mutants on apples

scientific article published on 22 October 2018

Fungal oxylipins direct programmed developmental switches in filamentous fungi

scientific article published on 14 October 2020

Fungal secondary metabolism - from biochemistry to genomics

scientific article

Fungal secondary metabolism: regulation, function and drug discovery

scientific article published on 01 March 2019

Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants

scientific article published on 11 November 2019

Genome-Based Cluster Deletion Reveals an Endocrocin Biosynthetic Pathway in Aspergillus fumigatus ⬇️

scientific article published on April 6, 2012

Genomic mining for Aspergillus natural products

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

scientific article

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence

scientific article

Global survey of canonical Aspergillus flavus G protein-coupled receptors

scientific article published on 14 October 2014

Growing a circular economy with fungal biotechnology: a white paper

scientific article published on 02 April 2020

Growth-Phase Sterigmatocystin Formation on Lactose Is Mediated via Low Specific Growth Rates in Aspergillus nidulans.

scientific article

H3K9 methylation regulates growth and development in Aspergillus fumigatus

scientific article published on 10 October 2008

Harnessing diverse transcriptional regulators for natural product discovery in fungi

scientific article published on 01 January 2020

HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production.

scientific article published on 27 June 2009

Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans

scientific article (publication date: June 2010)

Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds

scientific article published on 25 August 2020

Histone deacetylase activity regulates chemical diversity in Aspergillus

scientific article published on 6 July 2007

Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus ⬇️

scientific article published on 20 December 2012

Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis

scientific article

Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.

scientific article published on 28 September 2007

Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.

scientific article published on 9 April 2018

Illumina identification of RsrA, a conserved C2H2 transcription factor coordinating the NapA mediated oxidative stress signaling pathway in Aspergillus

scientific article

In the fungus where it happens: History and future propelling Aspergillus nidulans as the archetype of natural products research

scientific article published on 06 October 2020

Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity.

scientific article published on 13 March 2018

Involvement of transposon-like elements in penicillin gene cluster regulation.

scientific article published on 26 February 2010

Kit-On-A-Lid-Assays for accessible self-contained cell assays ⬇️

scientific article published on February 7, 2013

LaeA regulation of secondary metabolism modulates virulence in Penicillium expansum and is mediated by sucrose

scientific article published on 16 August 2016

LaeA, a global regulator of Aspergillus toxins

scientific article published on 01 September 2006

LaeA, a regulator of morphogenetic fungal virulence factors.

scientific article published on September 2005

LaeA, a regulator of secondary metabolism in Aspergillus spp

scientific article

Let's Get Physical: Bacterial-Fungal Interactions and Their Consequences in Agriculture and Health

scientific article published on 23 October 2020

Lipo-chitooligosaccharides as regulatory signals of fungal growth and development

scientific article published on 04 August 2020

Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus.

scientific article published on 9 May 2017

Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus.

scientific article published on 19 February 2013

Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites

scientific article (publication date: 2013)

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing

scientific article published on 02 August 2018

Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

scientific article published in 2021

Microbial metabolomics in open microscale platforms

scientific article

Microbial volatile communication in human organotypic lung models

scientific article published on 24 November 2017

Microevolution in the pansecondary metabolome of and its potential macroevolutionary implications for filamentous fungi

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Modeling Approaches Reveal New Regulatory Networks in Aspergillus fumigatus Metabolism

scientific article published on 14 July 2020

Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans ⬇️

scientific article

Multikingdom microscale models

scientific article published on 24 August 2017

Mutational Analysis of Aspergillus fumigatus Volatile Oxylipins in a Drosophila Eclosion Assay ⬇️

scientific article published on 24 March 2023

Mycotoxins in Conversation With Bacteria and Fungi

article by Nandhitha Venkatesh & Nancy P Keller published 2019 in Frontiers in Microbiology

NRPS-Derived Isoquinolines and Lipopetides Mediate Antagonism between Plant Pathogenic Fungi and Bacteria. ⬇️

scientific article

Natural products of filamentous fungi: enzymes, genes, and their regulation

scientific article published on 20 December 2006

Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish

scientific article published on 20 December 2019

New Insight Into Pathogenicity and Secondary Metabolism of the Plant Pathogen Penicillium expansum Through Deletion of the Epigenetic Reader SntB

scientific article published on 09 April 2020

NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion

scientific article

On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi

scientific article published on 07 February 2019

One Juliet and four Romeos: VeA and its methyltransferases.

scientific article

Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production

scientific article published on 27 August 2012

Oxygenase coordination is required for morphological transition and the host-fungus interaction of Aspergillus flavus

scientific article published in July 2009

Oxylipins act as determinants of natural product biosynthesis and seed colonization in Aspergillus nidulans

scientific article published on February 2006

Oxylipins as developmental and host-fungal communication signals

scientific article published on 2 February 2007

Pangenomics of the death cap mushroom Amanita phalloides, and of Agaricales, reveals dynamic evolution of toxin genes in an invasive range

scientific article published in 2023

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis

scientific article

Penicillium expansum: biology, omics, and management tools for a global postharvest pathogen causing blue mould of pome fruit

scientific article published on 23 September 2020

Peptide-Like Nylon-3 Polymers with Activity against Phylogenetically Diverse, Intrinsically Drug-Resistant Pathogenic Fungi.

scientific article

Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus ⬇️

scientific article

Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. ⬇️

scientific article published on 11 April 2016

Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus

scientific article published on 25 March 2016

Prototype of an intertwined secondary-metabolite supercluster

scientific article published on 30 September 2013

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.

scientific article published on 11 November 2016

Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues

scientific article

Real-time and semiquantitative RT-PCR methods to analyze gene expression patterns during Aspergillus-host interactions

scientific article

Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae

scientific article published on 27 May 2017

Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus

scientific article

Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus ⬇️

scientific article published on 4 August 2015

Regulation of aflatoxin synthesis by FadA/cAMP/protein kinase A signaling in Aspergillus parasiticus

scientific article published on August 2004

Regulation of secondary metabolism in filamentous fungi

scientific article

Regulation of secondary metabolite production in filamentous ascomycetes

scientific article published on 15 September 2007

Relationship between secondary metabolism and fungal development

scientific article

Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus

scientific article published on 11 July 2008

Requirement of spermidine for developmental transitions in Aspergillus nidulans

scientific article published in November 2002

Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor. ⬇️

scientific article published on 13 June 2016

Reversible S-nitrosylation limits over synthesis of fungal styrylpyrone upon nitric oxide burst

scientific article published on 22 March 2016

Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus Aspergillus

scientific article

RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis ⬇️

scientific article

Secondary metabolic gene cluster silencing in Aspergillus nidulans

scientific article published in September 2006

Secondary metabolism and development is mediated by LlmF control of VeA subcellular localization in Aspergillus nidulans

scientific article

Secondary metabolism in fungi: does chromosomal location matter?

scientific article

Secondary metabolism: Then, now and tomorrow ⬇️

scientific article published on September 16, 2010

Secondary metabolite arsenal of an opportunistic pathogenic fungus.

scientific article

Selenate sensitivity of a laeA mutant is restored by overexpression of the bZIP protein MetR in Aspergillus fumigatus

scientific article published on 09 May 2018

Spatial and temporal control of fungal natural product synthesis

scientific article

Spatial regulation of a common precursor from two distinct genes generates metabolite diversity

scientific article published on 13 July 2015

Strategies for mining fungal natural products

scientific article published on 22 October 2013

Suppressor mutagenesis identifies a velvet complex remediator of Aspergillus nidulans secondary metabolism

scientific article

Suspended microfluidics

scientific article

Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans.

scientific article published on 19 August 2010

The 2008 update of the Aspergillus nidulans genome annotation: a community effort

scientific article

The Antioxidant Gallic Acid Inhibits Aflatoxin Formation in Aspergillus flavus by Modulating Transcription Factors FarB and CreA

The Antioxidant Gallic Acid Inhibits Aflatoxin Formation in by Modulating Transcription Factors FarB and CreA

scientific article published on 03 July 2018

The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism

scientific article published on 9 January 2017

The Frequency of Sex: Population Genomics Reveals Differences in Recombination and Population Structure of the Aflatoxin-Producing Fungus Aspergillus flavus

scientific article published on 14 July 2020

The HosA Histone Deacetylase Regulates Aflatoxin Biosynthesis Through Direct Regulation of Aflatoxin Cluster Genes

scientific article published on 31 July 2019

The Zebrafish as a Model Host for Invasive Fungal Infections

scientific article published on 13 December 2018

The bZIP protein MeaB mediates virulence attributes in Aspergillus flavus

scientific article

The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici

scientific article published on 04 April 2015

The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus

scientific article published on 18 August 2018

The sexual spore pigment asperthecin is required for normal ascospore production and protection from UV light in <i>Aspergillus nidulans</i>

scientific article published in 2021

The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus

scientific article published on 18 February 2020

Toward Awakening Cryptic Secondary Metabolite Gene Clusters in Filamentous Fungi ⬇️

scientific article published on January 1, 2012

Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA

scientific article

Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus

scientific article published on 11 March 2015

TrpE feedback mutants reveal roadblocks and conduits toward increasing secondary metabolism in Aspergillus fumigatus

scientific article published on 14 December 2015

Unearthing fungal chemodiversity and prospects for drug discovery

scientific article published on 06 May 2019

Unlocking fungal cryptic natural products.

scientific article

Unraveling polyketide synthesis in members of the genus Aspergillus

scientific article

Use of Multiple Sequencing Technologies To Produce a High-Quality Genome of the Fungus Pseudogymnoascus destructans, the Causative Agent of Bat White-Nose Syndrome

scientific article published on 30 June 2016

VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation.

scientific article published on August 2013

VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism

scientific article

Waking Sleeping Pathways in Filamentous Fungi

bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans ⬇️

scientific article published on November 15, 2012

veA is required for toxin and sclerotial production in Aspergillus parasiticus

scientific article

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