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List of works by Jan van Benthem

2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair

scientific article

A critical appraisal of the process of regulatory implementation of novel in vivo and in vitro methods for chemical hazard and risk assessment

scientific article

A mode-of-action approach for the identification of genotoxic carcinogens

scientific article

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

scientific article

Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice

scientific article

Can carcinogenic potency be predicted from in vivo genotoxicity data? a meta‐analysis of historical data ⬇️

scientific article published on May 3, 2011

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.

scientific article published on 23 October 2014

Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells

scientific article

DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene.

scientific article published in March 2010

DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice

scientific article

Detecting genotoxic effects of potential clastogens: an in vivo study using the transgenic lacZ plasmid and the MutaMouse model

scientific article published on 23 February 2008

Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice

scientific article

Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis

scientific article

ECETOC workshop on the biological significance of DNA adducts: summary of follow-up from an expert panel meeting

scientific article

ECVAM retrospective validation of in vitro micronucleus test (MNT)

scientific article published on 7 March 2008

Evaluation of the Xpa-deficient transgenic mouse model for short-term carcinogenicity testing: 9-month studies with haloperidol, reserpine, phenacetin, and D-mannitol

scientific article published in March 2004

Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis

scientific article published on 9 November 2010

Follow‐up actions from positive results of in vitro genetic toxicity testing ⬇️

scientific article published on October 20, 2010

In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop ⬇️

scientific article published on April 5, 2011

Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe

scientific article published in September 2005

Is MutaMouse insensitive to clastogens?

scientific article published on 23 February 2008

Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop

scientific article published on 15 July 2015

Main issues addressed in the 2014-2015 revisions to the OECD Genetic Toxicology Test Guidelines

scientific article published on 7 March 2017

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

scientific article published on 22 July 2009

New and emerging technologies for genetic toxicity testing

scientific article published on 25 August 2010

New methods for assessing male germ line mutations in humans and genetic risks in their offspring

scientific article published on 20 May 2008

Opportunities to integrate new approaches in genetic toxicology: an ILSI-HESI workshop report

scientific article

Paternal exposure to environmental chemical stress affectsmale offspring's hepatic mitochondria

scientific article

Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice

scientific article published on 7 February 2006

Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data

scientific article

Reproductive toxicants have a threshold of adversity

scientific article published on 24 May 2011

Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

scientific article published on 4 November 2015

p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice

scientific article published in August 2004

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