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List of works by Henk van Loveren

A quantitative approach to assess the potency of skin sensitizers in the elicitation phase

scientific article published on May 4, 2012

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

scientific article

Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data

scientific article

Applicability of a keratinocyte gene signature to predict skin sensitizing potential ⬇️

scientific article published on August 28, 2012

Application of a systemic herpes simplex virus type 1 infection in the rat as a tool for sunscreen photoimmunoprotection studies

scientific article published in August 2002

Approaches to risk assessment of immunotoxic effects of chemicals

journal article published in 2001

Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI.

scientific article

Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics ⬇️

scientific article published on December 17, 2012

Characterization of the modes of action of deoxynivalenol (DON) in the human Jurkat T-cell line

scientific article

Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood

scientific article published on 27 March 2015

Current status and burning issues in immunotoxicity testing of drugs

scientific article

DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells

scientific article published on 15 November 2013

Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip").

scientific article

Development of an in vitro test to identify respiratory sensitizers in bronchial epithelial cells using gene expression profiling

scientific article published on 27 October 2015

Development of the ICH guidelines for immunotoxicology evaluation of pharmaceuticals using a survey of industry practices

scientific article published in July 2005

Developmental immunotoxicity in male rats after juvenile exposure to ethanol

scientific article published on 25 April 2013

Developmental immunotoxicity of chemicals in rodents and its possible regulatory impact

scientific article

Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study ⬇️

scientific article published on September 25, 2012

Developmental immunotoxicity of methylmercury: the relative sensitivity of developmental and immune parameters

scientific article published on 21 July 2010

Effect of prolonged exposure to low antigen concentration for sensitization

scientific article

Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials

scientific article

Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats

scientific article

Epidermal cis-urocanic acid levels correlate with lower specific cellular immune responses after hepatitis B vaccination of ultraviolet B-exposed humans

scientific article published in March 2003

Evaluation of in silico models for the identification of respiratory sensitizers

scientific article

Evaluation of the performance of the reduced local lymph node assay for skin sensitization testing ⬇️

scientific article published on February 28, 2013

Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis

scientific article published on 13 May 2011

Functional foods and dietary supplements: products at the interface between pharma and nutrition

scientific article published on 27 July 2011

Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events

scientific article published on 20 September 2013

Gene expression profiling of Bis(tri-n-butyltin)oxide (TBTO)-induced immunotoxicity in mice and rats

scientific article published in December 2006

Health claims in Europe: probiotics and prebiotics as case examples

scientific article published on 03 January 2012

Human relevance of an in vitro gene signature in HaCaT for skin sensitization

scientific article published on 16 September 2014

Immune function testing of human pharmaceuticals: regulatory overshoot?

scientific article

Immunotoxic effects of chemicals: A matrix for occupational and environmental epidemiological studies

scientific article published on December 2006

Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats

scientific article

In vitro assessment of sensitizing activity of low molecular weight compounds

scientific article

Induction of skin sensitization is augmented in Nrf2-deficient mice

scientific article published on November 11, 2012

Influence of the macrophage bacterial resistance gene, Nramp1 (Slc11a1), on the induction of allergic asthma in the mouse

scientific article published on 28 March 2003

Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants

scientific article published on 28 August 2015

Juvenile toxicity testing protocols for chemicals

scientific article published on 4 May 2012

Lactobacillus casei Shirota does not decrease the food allergic response to peanut extract in Brown Norway rats

scientific article published on 30 April 2008

Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase π isoform 2 (GSTπ2) in thymoma cells

scientific article published on 31 January 2014

Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort ⬇️

scientific article

Non-animal sensitization testing: state-of-the-art

scientific article published on May 2010

Novel foods: an explorative study into their grey area

scientific article published on 28 January 2009

Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure

scientific article

Phosphoproteomic Analysis of Mouse Thymoma Cells Treated With Tributyltin Oxide: TBTO Affects Proliferation and Energy Sensing Pathways ⬇️

scientific article published on December 15, 2011

Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood

scientific article published on 25 January 2013

Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood

scientific article published on 2 October 2012

Probiotics and prebiotics: health claim substantiation

scientific article

Probiotics: immunomodulation and evaluation of safety and efficacy

scientific article

Protein expression profiling of mouse thymoma cells upon exposure to the trichothecene deoxynivalenol (DON): Implications for its mechanism of action ⬇️

scientific article published on July 1, 2010

Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO).

scientific article

Repeated doses of UVR cause minor alteration in cytokine serum levels in humans

scientific article

Skin sensitization in chemical risk assessment: report of a WHO/IPCS international workshop focusing on dose-response assessment

scientific article

Statin-associated polymyalgia rheumatica. An analysis using WHO global individual case safety database: a case/non-case approach

scientific article

Status of nutrition and health claims in Europe

scientific article published on 22 April 2010

Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro

scientific article published on 25 November 2014

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

scientific article published on 03 March 2010

Suppression of contact hypersensitivity after repeated exposures of humans to low doses of solar simulated radiation

scientific article published on 15 June 2005

Suppression of different phases of systemic contact hypersensitivity by urocanic acid oxidation products

scientific article published in July 2004

The effects of deoxynivalenol on gene expression in the murine thymus

scientific article published on 11 November 2010

The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism

scientific article published on 26 December 2013

The involvement of the Toll-like receptor signaling and Nrf2-Keap1 pathways in the in vitro regulation of IL-8 and HMOX1 for skin sensitization

scientific article

The respiratory local lymph node assay as a tool to study respiratory sensitizers

scientific article published on 23 September 2008

Toxicogenomic profiles in relation to maternal immunotoxic exposure and immune functionality in newborns

scientific article

Toxicogenomics-based identification of mechanisms for direct immunotoxicity

scientific article published on 03 July 2013

Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

scientific article published on July 28, 2012

Transcriptome-based functional classifiers for direct immunotoxicity

scientific article published on 20 December 2013

Transcriptomic profile indicative of immunotoxic exposure: in vitro studies in peripheral blood mononuclear cells

scientific article published on 11 August 2010

Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO) ⬇️

scientific article published on March 14, 2012

Use of the local lymph node assay in assessment of immune function

scientific article published on 7 April 2005

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