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List of works by Bob van de Water

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

scientific article published on 29 April 2016

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

scientific article published on 6 March 2014

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

scientific article

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens

scientific article published on 2 October 2014

A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response

scientific article published on 02 February 2007

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.

scientific article published on 13 September 2013

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen

scientific article published on 24 November 2014

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

scientific article published on 31 May 2015

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

scientific article published on 19 July 2015

An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis

scientific article published on 31 May 2007

An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse

scientific article published on 24 May 2009

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

scientific article published on 2 July 2015

Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells

scientific article

Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation

scientific article

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening ⬇️

scientific article published on December 27, 2012

Automated whole animal bio-imaging assay for human cancer dissemination

scientific article

Cellular stress responses and molecular mechanisms of nephrotoxicity

scientific article

Cellular‐signaling pathways unveil the carcinogenic potential of chemicals ⬇️

scientific article published on January 22, 2013

Cross-talk between integrins and oncogenes modulates chemosensitivity

scientific article

Current approaches and future role of high content imaging in safety sciences and drug discovery

scientific article published on 14 July 2014

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

scientific article

Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells

scientific article published on 9 July 2002

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes ⬇️

scientific article published on May 19, 2011

Elucidation of Signaling Pathways from Large-Scale Phosphoproteomic Data Using Protein Interaction Networks

scientific article

Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure

scientific article published on 14 April 2011

Epac-Rap signaling reduces oxidative stress in the tubular epithelium

scientific article published on 7 February 2014

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation

scientific article

Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury

scientific journal article

Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemia/Reperfusion ⬇️

scientific article published on October 5, 2011

Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells

scientific journal article

Focal adhesion kinase: a potential target in cancer therapy

scientific article published on 25 September 2006

Functional screening with a live cell imaging-based random cell migration assay

scientific article

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

scientific article published on 17 October 2011

Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis

scientific article published on 8 June 2005

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

scientific article published on 29 June 2016

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

scientific article published on 26 March 2016

Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells

scientific article (publication date: 2013)

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

scientific article published on 07 February 2017

Integrins uncouple Src-induced morphological and oncogenic transformation

scientific article

Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice.

scientific article published on 18 June 2009

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model

scientific article

Pathways of proximal tubular cell death in bismuth nephrotoxicity

scientific article published in April 2002

Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling

scientific article published on 7 December 2005

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

scientific article

Phospho-proteomic analysis of cellular signaling

scientific article

Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells

scientific article published on 20 September 2004

Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells

scientific journal article

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment

scientific article published on 05 February 2014

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation

scientific article published on June 2005

Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment

scientific article published on 4 March 2011

Silencing of doublecortin-like (DCL) results in decreased mitochondrial activity and delayed neuroblastoma tumor growth

scientific article

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

scientific article (publication date: February 2017)

Stem cell-derived systems in toxicology assessment

scientific article

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells

scientific article published on 22 January 2013

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells ⬇️

scientific article published on October 24, 2012

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals ⬇️

scientific article published on October 14, 2011

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

scientific article published on 27 August 2015

The membrane attack complex of complement induces caspase activation and apoptosis

scientific article published in March 2002

The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch

scientific article published on 26 April 2013

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

scientific article published on 28 April 2009

Toxicogenomics directory of chemically exposed human hepatocytes

scientific article

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

scientific article

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

scientific article

Tumor-induced remote ECM network orientation steers angiogenesis

scientific article

Two-photon intravital multicolor imaging combined with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo

scientific article

Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo

scientific article published on January 2011

Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues

scientific article

Unraveling DNA damage response-signaling networks through systems approaches ⬇️

scientific article published on August 13, 2013

Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death

scientific article published on 12 December 2014

cAMP signalling protects proximal tubular epithelial cells from cisplatin‐induced apoptosis via activation of Epac ⬇️

scientific article published on February 1, 2012

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