List of works - Jérome Kluza

A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation.

scientific article published on 4 June 2010

AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation

scientific article published on 12 October 2018

Air pollution-derived PM impairs mitochondrial function in healthy and chronic obstructive pulmonary diseased human bronchial epithelial cells

scientific article published on 25 September 2018

Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production

scientific article published on 27 January 2014

Apoptosis induced by the alkaloid sampangine in HL-60 leukemia cells: correlation between the effects on the cell cycle progression and changes of mitochondrial potential

scientific article published on 01 December 2003

Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103

scientific article published on 01 August 2000

Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.

scientific article published on March 2006

Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response

scientific article published on 26 July 2016

Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients

article

Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.

scientific article published in June 2009

Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.

scientific article

Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells

scientific article

GILZ overexpression attenuates endoplasmic reticulum stress-mediated cell death via the activation of mitochondrial oxidative phosphorylation

scientific article published on 11 July 2016

Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors

scientific article published on 27 February 2018

Hx, a novel fluorescent, minor groove and sequence specific recognition element: design, synthesis, and DNA binding properties of p-anisylbenzimidazole-imidazole/pyrrole-containing polyamides.

scientific article published on 25 March 2011

Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants

scientific article

Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib

scientific article published on 27 October 2015

Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.

scientific article

Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D.

scientific article

Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics

scientific article

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

scientific article

Lipid Metabolism and Resistance to Anticancer Treatment

scientific article published on 16 December 2020

Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors

scientific article published on 31 January 2018

Metabolic features of melanoma: a gold mine of new therapeutic targets?

scientific article published on May 2014

Metabolic rewiring in cancer cells overexpressing the glucocorticoid-induced leucine zipper protein (GILZ): Activation of mitochondrial oxidative phosphorylation and sensitization to oxidative cell death induced by mitochondrial targeted drugs

scientific article published on March 2017

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol

scientific article

Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors

scientific article published on 29 February 2016

Mitochondrial oxidative stress is the Achille's heel of melanoma cells resistant to Braf-mutant inhibitor

scientific article

Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.

scientific article published on September 2004

Patient-derived tumor xenograft model to guide the use of BRAF inhibitors in metastatic melanoma

scientific article published in October 2013

Patient-derived tumor xenograft strategies for informed management of patients with metastatic melanoma

scientific article published on 01 June 2016

Plasma stability of two glycosyl indolocarbazole antitumor agents.

scientific article published in January 2003

Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature.

scientific article published on May 2009

Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.

scientific article

Relationship between cell cycle changes and variations of the mitochondrial membrane potential induced by etoposide

scientific article published on 01 July 2000

Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide.

scientific article published in February 2006

Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies

scientific article published on 13 September 2008

Study of AMPK-Regulated Metabolic Fluxes in Neurons Using the Seahorse XFe Analyzer.

scientific article

Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.

scientific article published on 10 October 2006

Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter

scientific article published on 01 November 2006

Targeting chelatable iron as a therapeutic modality in Parkinson's disease

scientific article

Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide.

scientific article published on 17 June 2010

Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer.

scientific article published on 22 October 2007

Ventricular Myocyte Caspases Are Directly Responsible for Endotoxin-Induced Cardiac Dysfunction

scientific article published on 16 May 2005

List of works by Jérome Kluza

A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation.

AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation

Air pollution-derived PM impairs mitochondrial function in healthy and chronic obstructive pulmonary diseased human bronchial epithelial cells

Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production

Apoptosis induced by the alkaloid sampangine in HL-60 leukemia cells: correlation between the effects on the cell cycle progression and changes of mitochondrial potential

Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103

Cancer cell mitochondria are direct proapoptotic targets for the marine antitumor drug lamellarin D.

Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response

Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients

Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.

Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.

Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells

GILZ overexpression attenuates endoplasmic reticulum stress-mediated cell death via the activation of mitochondrial oxidative phosphorylation

Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors

Hx, a novel fluorescent, minor groove and sequence specific recognition element: design, synthesis, and DNA binding properties of p-anisylbenzimidazole-imidazole/pyrrole-containing polyamides.

Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants

Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib

Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.

Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D.

Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

Lipid Metabolism and Resistance to Anticancer Treatment

Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors

Metabolic features of melanoma: a gold mine of new therapeutic targets?

Metabolic rewiring in cancer cells overexpressing the glucocorticoid-induced leucine zipper protein (GILZ): Activation of mitochondrial oxidative phosphorylation and sensitization to oxidative cell death induced by mitochondrial targeted drugs

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol

Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors

Mitochondrial oxidative stress is the Achille's heel of melanoma cells resistant to Braf-mutant inhibitor

Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.

Patient-derived tumor xenograft model to guide the use of BRAF inhibitors in metastatic melanoma

Patient-derived tumor xenograft strategies for informed management of patients with metastatic melanoma

Plasma stability of two glycosyl indolocarbazole antitumor agents.

Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature.

Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.

Relationship between cell cycle changes and variations of the mitochondrial membrane potential induced by etoposide

Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide.

Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies

Study of AMPK-Regulated Metabolic Fluxes in Neurons Using the Seahorse XFe Analyzer.

Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.

Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter

Targeting chelatable iron as a therapeutic modality in Parkinson's disease

Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide.

Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer.

Ventricular Myocyte Caspases Are Directly Responsible for Endotoxin-Induced Cardiac Dysfunction