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List of works by Chris Twelves

"New" metastases are associated with a poorer prognosis than growth of pre-existing metastases in patients with metastatic breast cancer treated with chemotherapy

scientific article

'Tablet burden' in patients with metastatic breast cancer

scientific article published on 28 December 2015

A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma ⬇️

scientific article published on 25 May 2016

A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen.

scientific article

A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors ⬇️

scientific article published on March 15, 2011

A four gene signature predicts benefit from anthracyclines: evidence from the BR9601 and MA.5 clinical trials

scientific article published on 10 September 2015

A multicentre phase I and pharmacokinetic study of BN80915 (diflomotecan) administered daily as a 20-min intravenous infusion for 5 days every 3 weeks to patients with advanced solid tumours

scientific article published on 01 March 2007

A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities

scientific article

A phase 1b/2, open-label, dose-escalation, and dose-confirmation study of eribulin mesilate in combination with capecitabine

scientific article published on 20 February 2019

A phase I clinical and pharmacokinetic study of Ro 31-7453 given as a 7- or 14-day oral twice daily schedule every 4 weeks in patients with solid tumors

scientific article published in July 2004

A phase I study of ZD0473 combined with paclitaxel for the treatment of solid malignancies

scientific article

A phase I/II study of oral uracil/tegafur (UFT), leucovorin and irinotecan in patients with advanced colorectal cancer

scientific article published on August 2003

A phase II, multicentre, UK study of vinorelbine in advanced breast cancer

scientific article

A qualitative investigation of the motivations, experiences and views of female sunbed users under the age of 18 in England

scientific article published on 30 January 2013

A randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancer

scientific article

ACCENT-based web calculators to predict recurrence and overall survival in stage III colon cancer

scientific article

ATTAIN: Phase III study of etirinotecan pegol versus treatment of physician's choice in patients with metastatic breast cancer and brain metastases

scientific article published on 10 May 2019

Acute reversible neurological deficit following intrathecal chemotherapy

scientific article (publication date: 1991)

Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials

scientific article

Answering patients' needs: oral alternatives to intravenous therapy

scientific article

Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients

scientific article published on 9 June 2014

Bioequivalence of two tablet formulations of capecitabine and exploration of age, gender, body surface area, and creatinine clearance as factors influencing systemic exposure in cancer patients

scientific article published on 01 January 1999

Breast cancer and liver metastases--incidence, diagnosis and outcome ⬇️

scientific article published on 01 August 1992

CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer

scientific article published on 22 September 2020

Can capecitabine replace 5-FU/leucovorin in combination with oxaliplatin for the treatment of advanced colorectal cancer?

scientific article

Capecitabine (Xeloda): from the laboratory to the patient's home

scientific article

Capecitabine as adjuvant treatment for stage III colon cancer

scientific article

Capecitabine named-patient programme for patients with advanced breast cancer. the UK experience

scientific article published in October 2002

Capecitabine plus docetaxel combination therapy

scientific article published in June 2005

Capecitabine versus 5-fluorouracil/folinic acid as adjuvant therapy for stage III colon cancer: final results from the X-ACT trial with analysis by age and preliminary evidence of a pharmacodynamic marker of efficacy ⬇️

scientific article published on September 6, 2011

Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II study

scientific article published on 01 March 2000

Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: post hoc analysis of a large phase II study

scientific article published in July 2005

Change in topoisomerase 1 (Top1) positive circulating tumor cells impacts overall survival in patients with advanced breast cancer after treatment with etirinotecan pegol

scientific article published on 4 April 2018

Characterizing and quantifying the effects of breast cancer therapy using mathematical modeling ⬇️

scientific article published on 19 January 2016

Chemotherapy of advanced breast cancer: outcome and prognostic factors

scientific article

Chromosome instability and benefit from adjuvant anthracyclines in breast cancer ⬇️

scientific article published on May 29, 2012

Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery

scientific article

Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests

scientific article

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study

scientific article

Clinical response to eribulin in patients with metastatic breast cancer is independent of time to first metastatic event. EMBRACE study group

Clinical roundtable monograph: effective management of quality of life in metastatic breast cancer

scientific article

Comparison of outcomes after fluorouracil-based adjuvant therapy for stages II and III colon cancer between 1978 to 1995 and 1996 to 2007: evidence of stage migration from the ACCENT database

scientific article

Conventional adjuvant chemotherapy versus single-cycle, autograft-supported, high-dose, late-intensification chemotherapy in high-risk breast cancer patients: a randomized trial

scientific article

Cytotoxic chemotherapy: Still the mainstay of clinical practice for all subtypes metastatic breast cancer ⬇️

scientific article

Defining the optimal schedule of drug administration: art or science?

scientific article published in April 2008

Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro ⬇️

scientific article published on April 2016

Designing phase II trials in cancer: a systematic review and guidance ⬇️

scientific article published on June 28, 2011

Detailed analysis of a randomized phase III trial: can the tolerability of capecitabine plus docetaxel be improved without compromising its survival advantage?

scientific article published on 01 September 2006

Determinants of Early Mortality Among 37,568 Patients With Colon Cancer Who Participated in 25 Clinical Trials From the Adjuvant Colon Cancer Endpoints Database

scientific article published on 8 February 2016

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

scientific article

Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer

scientific article published on 6 February 2016

Doxorubicin in advanced breast cancer: influence of schedule on response, survival and quality of life

scientific article published in January 1992

Doxorubicin pharmacokinetics: the effect of abnormal liver biochemistry tests ⬇️

scientific article published on 01 January 1998

Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: a pooled analysis of individual patient data from four randomised co

scientific article

Effect of erlotinib on CYP3A activity, evaluated in vitro and by dual probes in patients with cancer

scientific article published in August 2014

Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients ⬇️

scientific article published on 01 April 1998

Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites

scientific article published on 01 July 1999

Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients

scientific article

Efficacy of capecitabine versus 5-fluorouracil in colorectal and gastric cancers: a meta-analysis of individual data from 6171 patients

scientific article

Efficacy of eribulin for metastatic breast cancer based on localization of specific secondary metastases: a post hoc analysis

scientific article published on 08 July 2020

Efficacy of eribulin in women with metastatic breast cancer: a pooled analysis of two phase 3 studies

scientific article

Epirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancer

scientific article published in November 2006

Epirubicin in patients with liver dysfunction: development and evaluation of a novel dose modification scheme

scientific article published in March 2003

Eribulin monotherapy in patients aged 70 years and older with metastatic breast cancer

scientific article published on 28 March 2014

Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study.

scientific article published on 2 March 2011

Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: a dose-escalation study

scientific article

Erratum to: Efficacy of eribulin in women with metastatic breast cancer: a pooled analysis of two phase 3 studies

scientific article published in January 2015

Erratum to: Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial.

scientific article published on 7 September 2017

Etirinotecan pegol (NKTR-102) versus treatment of physician's choice in women with advanced breast cancer previously treated with an anthracycline, a taxane, and capecitabine (BEACON): a randomised, open-label, multicentre, phase 3 trial.

scientific article published on 15 October 2015

Evidence-driven, patient-specific approaches for optimizing survival prolongation in breast cancer

scientific article published on August 2014

First-in-human study of CH5132799, an oral class I PI3K inhibitor, studying toxicity, pharmacokinetics, and pharmacodynamics, in patients with metastatic cancer

scientific article

First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin

scientific article published on April 2002

HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data

scientific article

Haematological recovery following high-dose cyclophosphamide with autologous bone marrow transplantation

scientific article

Health-related quality of life in patients with locally advanced or metastatic breast cancer treated with eribulin mesylate or capecitabine in an open-label randomized phase 3 trial ⬇️

scientific article

Health-related quality of life in patients with locally recurrent or metastatic breast cancer treated with etirinotecan pegol versus treatment of physician's choice: Results from the randomised phase III BEACON trial ⬇️

scientific article

Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study

scientific article published on February 2008

Immune recruitment and therapeutic synergy: keys to optimizing oncolytic viral therapy?

scientific article

Impact of age on the efficacy of newer adjuvant therapies in patients with stage II/III colon cancer: findings from the ACCENT database

scientific article published on 03 June 2013

Impact of the number of prior chemotherapy regimens on outcomes for patients with metastatic breast cancer treated with eribulin: A post hoc pooled analysis

scientific article published on 29 November 2019

In situ detection of HER2:HER2 and HER2:HER3 protein–protein interactions demonstrates prognostic significance in early breast cancer ⬇️

scientific article published on June 3, 2011

Individualizing treatment to optimize survival outcomes in breast cancer

scientific article published on August 2013

Insulin-like growth factor - oestradiol crosstalk and mammary gland tumourigenesis ⬇️

scientific article

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. ⬇️

scientific article published in January 2018

Is TIMP-1 immunoreactivity alone or in combination with other markers a predictor of benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial? ⬇️

scientific article published on April 9, 2013

Membranous and cytoplasmic staining of Ki67 is associated with HER2 and ER status in invasive breast carcinoma

scientific article published in January 2009

Modelling residual disease volume and re-growth rates from response durations to aid in cancer trial design, interpretation and analysis, with a particular focus on breast cancer

scientific article published on 29 November 2013

Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer ⬇️

scientific article published on October 6, 2003

Moving forward with capecitabine: a glimpse of the future

scientific article

New frontiers and treatment paradigms for metastatic breast cancer. A Review of an adjunct symposium of the 2011 American Society of Clinical Oncology Annual Meeting, June 4, 2011 Chicago, Illinois

scientific article published on August 1, 2011

Novel treatment options in the management of metastatic breast cancer.

scientific article published on May 2011

Ongoing unmet needs in treating estrogen receptor-positive/HER2-negative metastatic breast cancer

scientific article published on 6 December 2017

Optimizing the management of HER2-negative metastatic breast cancer with capecitabine (Xeloda).

scientific article published in October 2004

Oral Capecitabine Compared With Intravenous Fluorouracil Plus Leucovorin in Patients With Metastatic Colorectal Cancer: Results of a Large Phase III Study ⬇️

scientific article published on November 1, 2001

Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial

scientific article published in December 2003

Pemetrexed: a multitargeted antifolate (ALIMTA, LY-231514).

scientific article

Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial

scientific article published on April 2006

Pharmacokinetic and exploratory exposure-response analysis of pertuzumab in patients with operable HER2-positive early breast cancer in the APHINITY study

scholarly article by Whitney P Kirschbrown et al published June 2019 in Cancer Chemotherapy and Pharmacology

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors

scientific article published in October 2007

Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer ⬇️

scientific article published on 01 September 1998

Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ring-modified camptothecin analogue in adults with solid tumors

scientific article published in September 2003

Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study

scientific article

Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors

scientific article published in August 2005

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses ⬇️

scientific article published on November 21, 2012

Phase I trial of intravenous aviscumine (rViscumin) in patients with solid tumors: a study of the European Organization for Research and Treatment of Cancer New Drug Development Group

scientific article

Phase I/II pilot study of intravesical apaziquone (EO9) for superficial bladder cancer

scientific article

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

scientific article published on 01 June 2009

Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme

scientific article (publication date: May 2002)

Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine

scientific article published on 02 August 2010

Phase III open-label randomized study of eribulin mesylate versus capecitabine in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline and a taxane ⬇️

scientific article published on 20 January 2015

Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer

scientific article

Phosphorus-31 metabolism of human breast--an in vivo magnetic resonance spectroscopic study at 1.5 Tesla

scientific article published on 01 January 1994

Phosphorus-31 metabolism of post-menopausal breast cancer studied in vivo by magnetic resonance spectroscopy

scientific article

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

scientific article published in January 2007

Population pharmacokinetic–pharmacodynamic modelling and simulation of neutropenia induced by TP300, a novel topoisomerase I inhibitor ⬇️

scientific article published on May 23, 2013

Potential regional differences for the tolerability profiles of fluoropyrimidines

scientific article published in May 2008

Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance

scientific article published on 05 July 2019

Predicting Anthracycline Benefit: TOP2A and CEP17-Not Only but Also

scientific article published on 20 April 2015

Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601).

scientific article published on 13 January 2010

Process mining routinely collected electronic health records to define real-life clinical pathways during chemotherapy ⬇️

scientific article published on 08 April 2017

Prognosis by breast cancer subtypes in patients treated with adjuvant chemotherapy in a clinical trial

Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the NEAT/BR9601 trial

scientific article published on 18 April 2013

Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial.

scientific article published on 13 June 2017

Quality of life in clinical trials of metastatic breast cancer

scientific article published in February 2014

Quality of life in women with advanced breast cancer treated with docetaxel

scientific article published in August 2004

Randomized, controlled trial investigating short-term health-related quality of life with doxorubicin and paclitaxel versus doxorubicin and cyclophosphamide as first-line chemotherapy in patients with metastatic breast cancer: European Organization f

article

Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients

scientific article published in February 2009

Recognizing the place of trials with treatment of physician's choice as the control arm.

scientific article published on 2 March 2015

Reimagining Global Oncology Clinical Trials for the Postpandemic Era: A Call to Arms

scientific article published on 01 September 2020

Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy

scientific article published on 22 June 2020

Safety and tolerability of etirinotecan pegol in advanced breast cancer: analysis of the randomized, phase 3 BEACON trial ⬇️

scientific article published on 08 July 2016

Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial

scientific article published on May 2009

Sex and adverse events of adjuvant chemotherapy in colon cancer: an analysis of 34,640 patients in the ACCENT database

scientific article published on 24 August 2020

Subgroup Analyses from a Phase 3, Open-Label, Randomized Study of Eribulin Mesylate Versus Capecitabine in Pretreated Patients with Advanced or Metastatic Breast Cancer ⬇️

scientific article published on 28 June 2016

Sunbed use in children aged 11-17 in England: face to face quota sampling surveys in the National Prevalence Study and Six Cities Study

scientific article

Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial results

scientific article

Survival following early-stage colon cancer: an ACCENT-based comparison of patients versus a matched international general population†.

scientific article published on 19 February 2015

Systemic treatment of hormone receptor positive, human epidermal growth factor 2 negative metastatic breast cancer: retrospective analysis from Leeds Cancer Centre

scientific article published on 21 January 2020

Targeting the protein kinase C family: are we there yet?

scientific article published in July 2007

The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study ⬇️

scientific article

The effect of different etiologies of hepatic impairment on the pharmacokinetics of gefitinib

Time to begin adjuvant chemotherapy and survival in breast cancer patients: a retrospective observational study using latent class analysis ⬇️

scientific article published on 13 November 2013

Treatment for anthracycline-pretreated metastatic breast cancer

scientific article

Treatment preference, adherence and outcomes in patients with cancer: literature review and development of a theoretical model

scientific article

Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours

scientific article published on 12 March 2020

Type 1 receptor tyrosine kinase profiles identify patients with enhanced benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial

scientific article published on 2 September 2008

Visibility of phospholipids in 31P NMR spectra of human breast tumours in vivo

scientific article published on 01 January 1992

Weekly epirubicin for breast cancer with liver metastases and abnormal liver biochemistry

scientific article

What is the effect of adjusting epirubicin doses for body surface area? ⬇️

scientific article published on September 1, 1998

Which endpoints should we use in evaluating the use of novel fluoropyrimidine regimens in colorectal cancer?

scientific article

XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer

scientific article

Xeloda in Adjuvant Colon Cancer Therapy (X-ACT) trial: overview of efficacy, safety, and cost-effectiveness

scientific article

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