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List of works by Alan Ashworth

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

scientific article (publication date: 14 April 2005)
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

scientific article
Large-scale genotyping identifies 41 new loci associated with breast cancer risk

scientific article
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

scientific article
The DNA damage response and cancer therapy

scientific article published on 18 January 2012
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

scientific article (publication date: 14 August 2003)
Resistance to therapy caused by intragenic deletion in BRCA2

scientific article
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

article by Nuala McCabe et al published 15 August 2006 in Cancer Research
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

scientific article published on October 1, 1997
Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

scientific article published on 20 April 2010
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

scientific article published on September 2010
PARP inhibitors: Synthetic lethality in the clinic

scientific article published on 16 March 2017
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

scientific article published on 30 April 2020
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

scientific article
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013
BRCAness revisited

scientific article
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

scientific article
Genome-wide association studies identify four ER negative-specific breast cancer risk loci

scientific article published in April 2013
BRCA1 dysfunction in sporadic basal-like breast cancer

scientific article
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

scientific article
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

scientific article
Germline mutations in RAD51D confer susceptibility to ovarian cancer

scientific article (publication date: 7 August 2011)
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

scientific article published on December 1, 1997
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells

scientific article
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland

scientific article
Mechanisms of resistance to therapies targeting BRCA-mutant cancers

scientific article published on 07 October 2013
Prediction of breast cancer risk based on profiling with common genetic variants

scientific article published on 8 April 2015
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

scientific article published on 03 April 2008
Breast cancer molecular profiling with single sample predictors: a retrospective analysis

scientific article
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study

scientific article published on 24 January 2011
Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

scientific article
Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors

scientific article
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

scientific article published on 01 November 1996
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

scientific article
Genome-wide association analysis identifies three new breast cancer susceptibility loci

scientific article published on 22 January 2012
BRCA2 mutations in primary breast and ovarian cancers

scientific article
Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

scientific article
Stem cells and breast cancer: A field in transit

scientific article published on November 2003
Targeted therapy for cancer using PARP inhibitors

scientific article published on August 2008
BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.

scientific article
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

scientific article published on 27 August 2010
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

scientific article
MAP kinase phosphatases

scientific article
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

scientific article
Utilizing RNA interference to enhance cancer drug discovery

scientific article published on July 2007
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas

scientific article published on November 2006
Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

scientific article published on May 2013
Emerging therapeutic targets in endometrial cancer

scientific article published on January 11, 2011
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors

scientific article published on October 2010
Analysis of PALB2/FANCN-associated breast cancer families

scientific article

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