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List of works by Alan Ashworth

11q13 is a susceptibility locus for hormone receptor positive breast cancer

scientific article

19p13.1 is a triple-negative-specific breast cancer susceptibility locus

scientific article published on 13 February 2012

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase ⬇️

scientific article published on October 1, 1997

9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium

scientific article published on 02 August 2012

A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1 ⬇️

scientific article published on December 12, 1991

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

scientific article

A conserved family of genes related to the testis determining gene, SRY

scientific article

A distinct spectrum of copy number aberrations in pediatric high-grade gliomas

scientific article published on 22 June 2010

A gene spans the pseudoautosomal boundary in mice

scientific article published on October 1997

A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity

scientific article

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

scientific journal article

A genome-wide association study of early menopause and the combined impact of identified variants

scientific article published on 9 January 2013

A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines

scientific article

A high-throughput screen identifies PARP1/2 inhibitors as a potential therapy for ERCC1-deficient non-small cell lung cancer

scientific article published on 12 August 2013

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium

scientific article

A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

scientific article published on 27 August 2010

A missense mutation in the BRCA2 gene in three siblings with ovarian cancer

scientific article

A modified method for whole exome resequencing from minimal amounts of starting DNA

scientific article

A mouse model of basal-like breast carcinoma with metaplastic elements

scientific article

A new gene on the X involved in Fanconi anemia

article

A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

scientific article published in Scientific Reports

A novel tumour-based test to identify breast cancer due to BRCA1 and BRCA2 mutations.

scientific article published on 18 May 2010

A protein interaction landscape of breast cancer

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells ⬇️

scientific article published on November 1, 1997

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

scientific article published on 03 April 2008

A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake

scientific article published on July 2003

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

scientific article published on 23 February 2012

A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis

scientific article published in October 1991

APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer

scientific article

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.

scientific article published on 13 December 2016

AXL and acquired resistance to EGFR inhibitors ⬇️

scientific article published on July 27, 2012

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

Abstract 2931: Cancer cells deficient in DNA mismatch repair (MMR) are selectively sensitive to inhibition of the DNA dependent protein kinase (DNA-PK)

scientific article published on 30 September 2014

Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes

article

Abstract 350: High-throughput drug screens identify novel synthetic lethal interactions with MLH1-deficient cancers

scientific article published on 15 April 2011

Abstract 3917: EMSY amplification and overexpression is not associated with defective homologous recombination and does not predict sensitivity to cisplatin or PARP inhibitors

article by Paul Wilkerson et al published 15 April 2011 in Cancer Research

Abstract 4829: Massively parallel RNA sequencing analysis of micropapillary carcinomas of the breast

article by Rachael Natrajan et al published 15 April 2011 in Cancer Research

Abstract 4987: Identification of novel genes and pathways involved in resistance to HER2-targeting agents in breast cancer

article

Abstract A09: Induced aggravation of oxidative DNA damage as a targeted synthetic lethal approach in mismatch repair-deficient tumors

article by Y. Fontebasso et al published 1 May 2013 in Molecular Cancer Therapeutics

Abstract A36: A transposon-based genetic screen in haploid mouse embryonic stem cells identifies Parp1 as a major mediator of olaparib toxicity

article

Abstract P3-08-04: Impact of CYP3A variation on estrone levels and breast cancer risk

Abstract PD05-08: Genomic characterisation of invasive breast cancers with heterogeneous HER2 gene amplification

article

Abstract S4-02: Integrated genomic analyses of members of protein kinase C family identifies subtype specific alterations as novel therapeutic targets

article by RC Natrajan et al published 15 December 2013 in Cancer Research

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge

article by S. Ammoun et al published 21 September 2011 in Neuro-Oncology

Alternative splicing of the Drosophila PTEN gene

scientific article published in October 1999

An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence

scientific article

An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein ⬇️

scientific article (publication date: October 1992)

An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor

scientific article published on 11 February 2014

An in vivo model of intratumoural aromatase using aromatase‐transfected MCF7 human breast cancer cells ⬇️

scientific article published on July 28, 1995

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

scientific article published on 18 August 2009

An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer

scientific article published on 10 June 2013

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

scientific article published on 27 April 2017

Analysis of PALB2/FANCN-associated breast cancer families

scientific article

Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss

scientific article published on June 2006

Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA.

scientific article

Association of genetic variants at 8q24 with breast cancer risk

scientific article

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium

scientific article published on 18 August 2011

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

scientific article

BRCA1 and BRCA2

scientific article published on 01 August 2000

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

scientific article published on September 2010

BRCA1 dysfunction in sporadic basal-like breast cancer

scientific article

BRCA2 mutations in primary breast and ovarian cancers

scientific article

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

scientific article published on September 2005

BRCAness revisited

scientific article

Basal-like breast carcinomas: clinical outcome and response to chemotherapy

scientific article published on 23 March 2006

Biology-driven cancer drug development: back to the future

scientific article

Biomedicine. D-Day for BRCA2

scientific article published on 13 June 2002

Body mass index, exercise, and other lifestyle factors in relation to age at natural menopause: analyses from the breakthrough generations study

scientific article published on 10 April 2012

Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis

scientific article (publication date: June 2010)

Breast cancer molecular profiling with single sample predictors: a retrospective analysis

scientific article

Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study

Bringing DNA repair in tumors into focus

scientific article

CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells

scientific article

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article

CRK7 modifies the MAPK pathway and influences the response to endocrine therapy

scientific article

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

scientific article (publication date: 14 August 2003)

CYP3A variation, premenopausal estrone levels, and breast cancer risk

scientific article published on 3 April 2012

Cancer predisposition: Where's the phosphate? ⬇️

scientific article published on March 26, 1998

Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis

scientific article published on January 2007

Cell cycle and genetic background dependence of the effect of loss of BRCA2 on ionizing radiation sensitivity

scientific article published on May 2003

Challenges translating breast cancer gene signatures into the clinic

scientific article published on 30 August 2011

Changes in estradiol and testosterone levels in postmenopausal women after changes in body mass index

scientific article published on 10 May 2013

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

scientific article

Childhood body size and pubertal timing in relation to adult mammographic density phenotype

scientific article published on 07 February 2017

Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)

scientific article

Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene

scientific article

Combined effects of endogenous sex hormone levels and mammographic density on postmenopausal breast cancer risk: results from the Breakthrough Generations Study

scientific article published on 11 February 2014

Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study

scientific article

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium

scientific article

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

scientific article published in February 2018

Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

scientific article

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

scientific article

Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer

scientific article

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation

scientific article published in November 2009

Control of aromatase in breast cancer cells and its importance for tumor growth

scientific article published on 01 March 1993

Correction to: Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study

scientific article published on 11 February 2020

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article published on 20 April 2017

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article published on 18 April 2016

Correction: Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

scientific article published in PLoS ONE

Correction: Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

scientific article published in PLoS ONE

Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

scientific article

Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer

scientific article published on 10 March 2016

Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress

scientific article

DAISY: picking synthetic lethals from cancer genomes

scientific article published in September 2014

DNA amplifications in breast cancer: genotypic-phenotypic correlations

scientific article published on June 2010

DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5

scientific article

DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1

scientific article

DNA repair deficiency as a therapeutic target in cancer

scientific article published on February 2008

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade

scientific article published on 15 February 2018

DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells

scientific journal article

De novo design of drug-binding proteins with predictable binding energy and specificity

scientific article published on 04 April 2024

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

article by Nuala McCabe et al published 15 August 2006 in Cancer Research

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

scientific article

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

scientific article

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

article

Determinants of age at menarche in the UK: analyses from the Breakthrough Generations Study

scientific article

Differential effects of stress stimuli on a JNK-inactivating phosphatase

scientific article published on April 2002

Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways

scientific article

Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1

scientific article (publication date: October 2003)

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

scientific article

Dissecting resistance to endocrine therapy in breast cancer

scientific article

Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland

scientific article

Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue

scientific article published on February 2006

Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis

scientific article published in September 2009

Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study

scientific article published on 23 January 2018

Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling

scientific article published on 28 August 2014

Dynamic expression of Erbb pathway members during early mammary gland morphogenesis

scientific article published on 25 October 2007

Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours

scientific article published on 09 May 2011

Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study

scientific article published on 06 August 2013

Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

scientific article

Emerging therapeutic targets in endometrial cancer ⬇️

scientific article published on January 11, 2011

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

scientific article published on 4 August 2015

Erratum to: Functional and molecular characterisation of mammary side population cells

scientific article

Erratum: Identification of the breast cancer susceptibility gene BRCA2

scientific article published in Nature

Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation

scientific article

Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data

scientific article

Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation

scientific article published in January 2007

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

scientific article

Evolutionary rate of a gene affected by chromosomal position

scientific article published in September 1999

Exome Sequencing of an Adult Pituitary Atypical Teratoid Rhabdoid Tumor

scientific article

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

scientific article published on February 2014

FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo

scientific article

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

scientific article

FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas

scientific article published on November 2006

FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma

article published in 2011

FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules.

scientific article

Familial concordance for age at menarche: analyses from the Breakthrough Generations Study

scientific article published on 14 January 2011

Familial concordance for age at natural menopause: results from the Breakthrough Generations Study

scientific article published on September 2011

Familial concordance for height and its components: analyses from the Breakthrough Generations Study

scientific article published on 28 November 2011

Family history and risk of breast cancer: an analysis accounting for family structure

scientific article published on 03 June 2017

Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls

scientific article published on January 2009

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.

scientific article published on 4 February 2015

Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.

scientific article

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.

scientific article

Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1 ⬇️

scientific article published on April 23, 2012

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

scientific article published on 24 November 2020

Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia

scientific article published on 01 September 1996

Functional analysis of Drosophila melanogaster BRCA2 in DNA repair

scientific article published on 5 September 2007

Functional and molecular characterisation of mammary side population cells

scientific article

Functional characterization of EMSY gene amplification in human cancers

scientific article published on 7 July 2011

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

scientific article published on 27 March 2013

Functional viability profiles of breast cancer

scientific article

Gene expression following ionising radiation: identification of biomarkers for dose estimation and prediction of individual response

scientific article published on 10 November 2010

Gene expression patterns for doxorubicin (Adriamycin) and cyclophosphamide (cytoxan) (AC) response and resistance

scientific article published in February 2006

Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study

scientific article

Genetic predisposition to in situ and invasive lobular carcinoma of the breast

scientific article

Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men

scientific article

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

scientific article

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

scientific article

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

scientific article

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

scientific article published on 10 May 2018

Genome-wide association analysis identifies three new breast cancer susceptibility loci

scientific article published on 22 January 2012

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

scientific article

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

scientific article published in April 2013

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

scientific article

Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells

scientific article

Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

scientific article published on 11 April 2011

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity

scientific article

Genome-wide screening for genetic changes in a matched pair of benign and prostate cancer cell lines using array CGH.

scientific article published on January 2005

Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation

scientific article published in September 2009

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

scientific article published on 13 March 2015

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines

scientific article

Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast

scientific article published on 7 May 2010

Genomic characterisation of acral melanoma cell lines

scientific article published on July 2012

Genomic instability and the selection of treatments for cancer

scientific article published on January 2010

Germline mutations in RAD51D confer susceptibility to ovarian cancer

scientific article (publication date: 7 August 2011)

Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way.

scientific article published on June 2004

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

scientific article

High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

scientific article

High-throughput RNAi screening reveals novel regulators of telomerase

scientific article

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

scientific article published on May 2013

IRF4 polymorphism rs872071 and risk of Hodgkin lymphoma

scientific article published on 5 October 2009

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

scientific article

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

scientific article

Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

scientific article

Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines

scientific article

Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy

Identification of miRNA modulators to PARP inhibitor response

scientific article published on 6 April 2013

Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions

scientific article

Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers

scientific article

Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification

scientific journal article

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

scientific article

Identifying Modifiers of Tamoxifen Sensitivity Using High-Throughput Genetic and Chemical Screens

scholarly article

Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk

scientific article

Inherited cylindromas: lessons from a rare tumour

scientific article published on September 2015

Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer

scientific article

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

scientific article

Integrated functional, gene expression and genomic analysis for the identification of cancer targets

scientific article

Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies

scientific article published on 21 January 2013

Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

scientific article

Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study

scientific article

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

scientific article

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

scientific article published on February 2006

Intestinal renin-angiotensin system is stimulated after deletion of Lkb1.

scientific article published on 3 August 2011

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

scientific article

Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk

scientific article published on 28 February 2012

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

scientific article

JNK activation is not required for Fas-mediated apoptosis

scientific article published on June 1999

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

scientific article published on 06 May 2010

LKB1 kinase: master and commander of metabolism and polarity

scientific article

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

scientific article published on 2 March 2016

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

scientific article

Linkage mapping of murine homolog of the yeast SPT6 gene to MMU11B1.

scientific article published in June 1996

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine

scientific article

Lkb1 deficiency causes prostate neoplasia in the mouse

scientific journal article

Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?

scientific article published in April 2009

MAP kinase phosphatases

scientific article

MESH: Phase II trial of methotrexate as a synthetic lethal therapy for metastatic MSH2-deficient colorectal and other tumors

article by M. Hewish et al published 20 May 2010 in Journal of Clinical Oncology

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

scientific article

Making the best of PARP inhibitors in ovarian cancer

scientific article published on 10 August 2010

Male breast cancer, age and sex chromosome aneuploidy

scientific article

Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer

scientific article

Mapping of two zinc finger protein genes to mouse chromosomes 4 and 7.

scientific article

Mechanisms of disease: angiogenesis and the management of breast cancer

scientific article published on September 2007

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

scientific article published on 07 October 2013

Menopausal hormone therapy and breast cancer: what is the true size of the increased risk?

scientific article published on 28 July 2016

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

scientific article

MicroRNA related polymorphisms and breast cancer risk

scientific article

Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement

scientific article

Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy

scientific article published on 28 November 2006

Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma

scientific article published on December 2009

Mismatch repair deficient colorectal cancer in the era of personalized treatment

scientific article published on 23 February 2010

Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls

scientific article

Mitochondrial DNA Copy Number in Peripheral Blood Cells and Risk of Developing Breast Cancer

scientific article published on 14 May 2015

Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components.

scientific article published in July 2009

Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

scientific article published on 15 June 2017

Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas

scientific article

Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4

scientific article

Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas

scientific article published in July 2008

Molecular response to aromatase inhibitor treatment in primary breast cancer

scientific article published in January 2007

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

scientific article

Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type

scientific article published on November 2010

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013

NLK is a novel therapeutic target for PTEN deficient tumour cells

scientific article published on 29 October 2012

Neuregulin3 alters cell fate in the epidermis and mammary gland

scientific article

New biology of the oestrogen receptor

scientific article published on 01 July 2003

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

scientific article published in May 2015

Noninvasive Detection of HER2 Amplification with Plasma DNA Digital PCR ⬇️

scientific article published on June 15, 2013

Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study

scientific article published on 24 January 2011

Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells

scientific article

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway

scientific article published on May 2015

Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007.

scientific article published on 21 December 2007

Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells

scientific article published on 11 March 2016

P1-06-22: Identification of Biomarkers in Breast Cancer for Prediction of Response to PARP Inhibitor Olaparib

article by A Daemen et al published 15 December 2011 in Cancer Research

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

scientific article published in December 2016

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

article by Roman M Chabanon et al published 1 March 2019 in Journal of Clinical Investigation

PARP inhibitor combination therapy

scientific article published on 31 October 2016

PARP inhibitors: Synthetic lethality in the clinic

scientific article published on 16 March 2017

PD-0017 * DRUGGABLE GENETIC DEPENDENCIES FOR MOLECULARLY DEFINED SUBGROUPS OF OESOPHAGEAL CANCER IDENTIFIED FROM HIGH-THROUGHPUT FUNCTIONAL PROFILING

scientific article published in June 2014

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

scientific article published on 11 June 2010

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

scientific article published on 17 March 2009

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors

scientific article published on October 2010

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer ⬇️

scientific article published on 6 June 2013

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

scientific article

Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers

scientific article published on 17 January 2011

Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region

scientific article published in December 1998

Perilobar nephrogenic rests are nonobligate molecular genetic precursor lesions of insulin-like growth factor-II-associated Wilms tumors

scientific article published on December 2008

Phenotypic effects of heterozygosity for a BRCA2 mutation

scientific article published on 19 August 2003

Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity

scholarly article by Jorge Reis-Filho et al published 2005 in Journal of Pathology

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

scientific article published on 20 April 2010

Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency

scientific article published on 23 May 2013

Preclinical evaluation of PARP inhibition as a treatment for endometrioid endometrial carcinomas

article by K. J. Dedes et al published 20 May 2010 in Journal of Clinical Oncology

Prediction of breast cancer risk based on profiling with common genetic variants

scientific article published on 8 April 2015

Pregnancy and the risk of breast cancer

scientific article published on December 2007

Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells

scientific article published on 23 April 2009

Profiling familial breast cancer

scientific article published on 01 April 2001

Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom

scientific article published on 15 July 2016

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

scientific article published on 10 April 2018

RNA interference screening demystified

scientific article

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells

scientific article

Reelin as a candidate gene for schizophrenia

article

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1

scientific article (publication date: 24 July 2003)

Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers

scientific article

Reply to 'Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study"

article by Louise E Johns et al published May 2018 in British Journal of Cancer

Reproducibility of Estradiol and Testosterone Levels in Postmenopausal Women Over 5 Years: Results From the Breakthrough Generations Study

scientific article published on 30 March 2014

Resistance to therapy caused by intragenic deletion in BRCA2

scientific article

Response to 'Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study"

scientific article published on 17 October 2018

Response to ‘Comment on ‘Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study”

scientific article published on 25 December 2018

Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line

scientific article

Searching for synthetic lethality in cancer

scientific article published on 20 January 2011

Secondary mutations inBRCA2associated with clinical resistance to a PARP inhibitor

article by Louise J Barber et al published 25 January 2013 in Journal of Pathology

Secular trends in age at menarche in women in the UK born 1908-93: results from the Breakthrough Generations Study

scientific article published on 26 May 2011

Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer

scientific article

Sequence of cDNA for Xenopus XZFY-1 ⬇️

scientific article published on November 11, 1992

Signalling pathways implicated in early mammary gland morphogenesis and breast cancer

scientific article published in August 2006

Smoking and risk of breast cancer in the Generations Study cohort

scientific article published on 22 November 2017

Stem cells and breast cancer: A field in transit

scientific article published on November 2003

Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations

scientific article published in April 2002

Structural basis for recruitment of BRCA2 by PALB2

scientific article

Structural basis for recruitment of BRCA2 by PALB2.

scientific article published on July 2017

Structural variation of the pseudoautosomal region between and within inbred mouse strains.

scientific article

Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse

scientific article published in November 1998

Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma

scientific article

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib

scientific article

Synthetic lethal approaches to breast cancer therapy

scientific article published on 19 October 2010

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

scientific article

Synthetic lethal therapies for cancer: what's next after PARP inhibitors?

article by Alan Ashworth et al published September 2018 in Nature Reviews Clinical Oncology

Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors

scientific article

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

scientific article

Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations

scientific article

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

scientific article published on December 2012

Targeted therapy for cancer using PARP inhibitors

scientific article published on August 2008

Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer

scientific article

Targeting Tropomyosin Receptor Kinase in Cutaneous CYLD Defective Tumors With Pegcantratinib: The TRAC Randomized Clinical Trial ⬇️

scholarly article by Marina Danilenko et al published 1 August 2018 in JAMA Dermatology

Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers

scientific article

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

scientific article (publication date: 14 April 2005)

Targeting the DNA repair defect of BRCA tumours

scientific article

Targeting the double-strand DNA break repair pathway as a therapeutic strategy

scientific article published on August 2006

Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study

scientific article

The BRC repeats are conserved in mammalian BRCA2 proteins

scientific article

The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology

scientific article

The DNA damage response and cancer therapy

scientific article published on 18 January 2012

The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity ⬇️

scientific article published on April 10, 1998

The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse

scientific article

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling

scientific article published on December 2014

The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

scientific article published on 01 November 1996

The effect of the stromal component of breast tumours on prediction of clinical outcome using gene expression microarray analysis

scientific article

The genomic landscape of oesophagogastric junctional adenocarcinoma

scientific article

The genomic profile of HER2-amplified breast cancers: the influence of ER status

scientific article

The human FXY gene is located within Xp22.3: implications for evolution of the mammalian X chromosome

scientific article published in February 1998

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature

scientific article published on 27 May 2022

The mouse Ftzf1 gene required for gonadal and adrenal development maps to mouse chromosome 2.

scientific article

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

scientific journal article

The potential of exploiting DNA-repair defects for optimizing lung cancer treatment

scientific article published on 14 February 2012

The promise of combining inhibition of PI3K and PARP as cancer therapy.

scientific article

The proteasome is involved in determining differential utilization of double-strand break repair pathways

article by K Gudmundsdottir et al published 29 November 2007 in Oncogene

The relationship between obesity and exposure to light at night: cross-sectional analyses of over 100,000 women in the Breakthrough Generations Study

scientific article published on 29 May 2014

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

scientific article

The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells

scientific article published on 01 March 1994

Therapeutic targeting of the DNA mismatch repair pathway

scientific article published on 07 September 2010

Tiling path genomic profiling of grade 3 invasive ductal breast cancers

scientific article published on 24 March 2009

Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study

scientific article published on 04 February 2014

Transgenic mice carrying an Xist-containing YAC.

scientific article published in April 1996

Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression

scientific article published on 19 May 2011

Tropomyosin Receptor Antagonism in Cylindromatosis (TRAC), an early phase trial of a topical tropomyosin kinase inhibitor as a treatment for inherited CYLD defective skin tumours: study protocol for a randomised controlled trial

scientific article published on 07 March 2017

Tumor mapping in 2 large multigenerational families with CYLD mutations: implications for disease management and tumor induction

scientific article

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation ⬇️

scientific article published on December 1, 1997

Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.

scientific article

Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization

scientific article

Utilizing RNA interference to enhance cancer drug discovery

scientific article published on July 2007

Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor

scientific article published on 26 April 2012

Whole genome sequencing of matched primary and metastatic acral melanomas

scientific article

Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours

scientific article published on 2 April 2015

X-chromosome inactivation may explain the difference in viability of XO humans and mice

scientific article

X-chromosome inactivation: X marks the spot for BRCA1.

scientific article published in January 2003

X-linked microtubule-associated protein, Mid1, regulates axon development

scientific article

Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene ⬇️

scientific article published on May 1, 1990

Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.

scientific article published in October 1994

Zinc finger protein genes in the mouse genome

scientific article published on January 1991

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

scientific article published on 01 January 1995

p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

scientific article published on February 2006

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