Search filters

List of works by Peter van der Ley

A Neisserial autotransporter NalP modulating the processing of other autotransporters ⬇️

scientific article published on November 1, 2003

A novel secondary acyl chain in the lipopolysaccharide of Bordetella pertussis required for efficient infection of human macrophages

scientific article published on 29 October 2007

Acellular pertussis vaccine based on outer membrane vesicles capable of conferring both long-lasting immunity and protection against different strain genotypes

scientific article

Agonists of Toll-like receptors 3, 4, 7, and 9 are candidates for use as adjuvants in an outer membrane vaccine against Neisseria meningitidis serogroup B.

scientific article

Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains ⬇️

scientific article published on January 9, 2013

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant

scientific article published on 22 March 2015

Bordetella pertussis naturally occurring isolates with altered lipooligosaccharide structure fail to fully mature human dendritic cells

scientific article

Coincorporation of LpxL1 and PagL mutant lipopolysaccharides into liposomes with Neisseria meningitidis opacity protein: influence on endotoxic and adjuvant activity

scientific article

Conformational analysis of opacity proteins from Neisseria meningitidis

scientific article published in November 2002

Construction of Opa-positive and Opa-negative strains of Neisseria meningitidis to evaluate a novel meningococcal vaccine

scientific article

Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa

scientific journal article

Cysteine Depletion Causes Oxidative Stress and Triggers Outer Membrane Vesicle Release by Neisseria meningitidis; Implications for Vaccine Development ⬇️

scientific article published on January 23, 2013

Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis

scientific article published on 19 May 2008

Differential effect of TLR2 and TLR4 on the immune response after immunization with a vaccine against Neisseria meningitidis or Bordetella pertussis

scientific article

Dissemination of lipid A deacylases (pagL) among gram-negative bacteria: identification of active-site histidine and serine residues

scientific journal article

Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity

scientific article published in September 2002

Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of Bordetella pertussis

scientific article

Human dendritic cell activation by Neisseria meningitidis: phagocytosis depends on expression of lipooligosaccharide (LOS) by the bacteria and is required for optimal cytokine production

scientific article

Human lipoproteins have divergent neutralizing effects on E. coli LPS, N. meningitidis LPS, and complete Gram-negative bacteria

scientific article published in February 2004

Identification of a novel lipopolysaccharide core biosynthesis gene cluster in Bordetella pertussis, and influence of core structure and lipid A glucosamine substitution on endotoxic activity

scientific article published on 13 April 2009

Involvement of lipooligosaccharides of Haemophilus influenzae and Neisseria meningitidis in defensin-enhanced bacterial adherence to epithelial cells

scientific article published on March 2003

LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A

scientific article

Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses

scientific article published on 21 November 2012

Lipopolysaccharide analogs improve efficacy of acellular pertussis vaccine and reduce type I hypersensitivity in mice

scientific article

Lipopolysaccharide engineering in Neisseria meningitidis: structural analysis of different pentaacyl lipid A mutants and comparison of their modified agonist properties

scientific article published on 03 February 2014

Llama single-chain antibody that blocks lipopolysaccharide binding and signaling: prospects for therapeutic applications

scientific article published on 23 August 2006

Mannose binding lectin enhances IL-1beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis

scientific article published in October 2004

Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors ⬇️

scientific article published on November 1, 2003

Meningitis caused by a lipopolysaccharide deficient Neisseria meningitidis

scientific article published on 13 June 2014

Meningococcal Outer Membrane Vesicle Composition-Dependent Activation of the Innate Immune Response

scientific article published on August 2016

Modulating endotoxin activity by combinatorial bioengineering of meningococcal lipopolysaccharide.

scientific article published on 14 November 2016

Modulation of the CD4(+) T cell response after acellular pertussis vaccination in the presence of TLR4 ligation

scientific article published on 7 February 2015

Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy

scientific article

Opa+ and Opa- isolates of Neisseria meningitidis and Neisseria gonorrhoeae induce sustained proliferative responses in human CD4+ T cells

scientific article published on 31 August 2009

Outer membrane vesicles as platform vaccine technology

scientific article

Phase variation of Opa proteins of Neisseria meningitidis and the effects of bacterial transformation

scientific article published in March 2016

Prevalence and clinical course in invasive infections with meningococcal endotoxin variants

scientific article

Relative Immunogenicity of PorA Subtypes in a Multivalent Neisseria meningitidis Vaccine Is Not Dependent on Presentation Form ⬇️

scientific article published on November 1, 2003

Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: modification of vaccine-induced immune responses

scientific article published on 31 December 2007

Surface display of a borrelial lipoprotein on meningococcal outer membrane vesicles

scientific article published on 19 January 2016

TLR4-dependent adjuvant activity of Neisseria meningitidis lipid A

scientific article published on 02 April 2007

Teasing apart structural determinants of 'toxicity' and 'adjuvanticity': implications for meningococcal vaccine development

scientific article published on January 2004

Th17-mediated cross protection against pneumococcal carriage by vaccination with a variable antigen

scientific article published on 20 September 2017

The Omp85 protein of Neisseria meningitidis is required for lipid export to the outer membrane

scientific article

The structure of Neisseria meningitidis lipid A determines outcome in experimental meningococcal disease

scientific article

Working mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 Protease

scientific article published on October 2005

Paulina is supported by:

About Paulina

Help