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List of works by Andrew Raubitschek

124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice

scientific article

161 Evaluating changes in stable chromosomal translocation frequency as a biodosimeter in patients receiving radioimmunotherapy

scholarly article

A CT assisted method for absolute quantitation of internal radioactivity

scientific article published in November 1996

A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer

scientific article published on December 2003

A chimeric anti-CEA antibody with heavy interchain disulfide bonds deleted: molecular characterization and biodistributions in normal and tumor bearing mice

scientific article published on 01 January 1999

A facile, water-soluble method for modification of proteins with DOTA. Use of elevated temperature and optimized pH to achieve high specific activity and high chelate stability in radiolabeled immunoconjugates

scientific article published in November 1994

A method for patient-specific absorbed dose estimation for internal beta emitters.

scientific article published on October 1999

A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma

scientific article published on 7 July 2005

A phase I radioimmunotherapy trial evaluating 90yttrium-labeled anti-carcinoembryonic antigen (CEA) chimeric T84.66 in patients with metastatic CEA-producing malignancies.

scientific article

A phase I study of a combination of yttrium-90-labeled anti-carcinoembryonic antigen (CEA) antibody and gemcitabine in patients with CEA-producing advanced malignancies

scientific article published on 7 April 2009

A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies

scientific article

A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer

scientific article

A radionuclide therapy treatment planning and dose estimation system

scientific article published on July 1999

A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance

scientific article published on 21 November 2012

A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodies

scientific article published on 8 November 2007

Adoptive Cellular Therapy for Follicular Lymphoma Using Genetically-Modified Autologous CD20-Specific T Cells. ⬇️

scholarly article

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

scientific article published on 28 May 2008

An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma.

scientific article published on 3 February 2005

An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.

scientific article published in March 2001

Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.

scientific article published on May 2008

Autologous transplantation for transformed non-Hodgkin lymphoma using an yttrium-90 ibritumomab tiuxetan conditioning regimen

scientific article published on 29 July 2014

Biodistribution and radioimmunotherapy of human breast cancer xenografts with radiometal-labeled DOTA conjugated anti-HER2/neu antibody 4D5.

scientific article

Biodistribution and tumor imaging of an anti-CEA single-chain antibody-albumin fusion protein

scientific article

Biodistribution of 111In- and 90Y-Labeled DOTA and Maleimidocysteineamido-DOTA Conjugated to Chimeric Anticarcinoembryonic Antigen Antibody in Xenograft-Bearing Nude Mice: Comparison of Stable and Chemically Labile Linker Systems ⬇️

scientific article published on January 1, 1998

Biophotonic cytotoxicity assay for high-throughput screening of cytolytic killing

scientific article

CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy

scientific article published on January 1998

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results ⬇️

scientific article published on February 3, 2012

Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy

scientific article

Cellular immunotherapy for follicular lymphoma using genetically modified CD20-specific CD8+ cytotoxic T lymphocytes

scientific article published on April 2004

Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting

scientific article published on April 2004

Clinical evaluation of indium-111-labeled chimeric anti-CEA monoclonal antibody ⬇️

scientific article published on December 1, 1997

Combined radioimmunotherapy and chemotherapy of breast tumors with Y-90-labeled anti-Her2 and anti-CEA antibodies with taxol

scientific article published on September 2005

Combining adoptive cellular and immunocytokine therapies to improve treatment of B-lineage malignancy

scientific article published on March 2007

Comparative Analysis of Autologous Hematopoietic Cell Transplantation with Radioimmunotherapy (RIT) Based Conditioning Versus Total Body Irradiation (TBI) for High-Risk Diffuse Large Cell Lymphoma (DLCL): Toxicity and Efficacy ⬇️

scholarly article

Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

scientific article

DI-Leu16-IL2, an Anti-CD20-Interleukin-2 Immunocytokine, Is Safe and Active in Patients with Relapsed and Refractory B-Cell Lymphoma: A Report of Maximum Tolerated Dose, Optimal Biologic Dose, and Recommended Phase 2 Dose ⬇️

scholarly article

Development and application of CD19-specific T cells for adoptive immunotherapy of B cell malignancies

scientific article published in July 2004

Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients.

scientific article

Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy

scientific article published in January 2003

Estimating residence times and their associated errors in patient absorbed-dose calculation ⬇️

scientific article published on December 1, 1997

Evaluating changes in stable chromosomal translocation frequency in patients receiving radioimmunotherapy.

scientific article

Figures of merit (FOMs) for imaging and therapy using monoclonal antibodies

scientific article published in December 1995

Functional imaging of human epidermal growth factor receptor 2-positive metastatic breast cancer using (64)Cu-DOTA-trastuzumab PET.

scientific article

High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment

scientific article published on July 2000

Human T lymphocyte genetic modification with naked DNA.

scientific article published on January 2000

Humanization of the anti-CEA T84.66 antibody based on crystal structure data

scientific article

Imaging glioma extent with 131I-TM-601.

scientific article

Imaging immune response in vivo: cytolytic action of genetically altered T cells directed to glioblastoma multiforme

scientific article published on June 2008

ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies).

scientific article

Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody

scientific article published on January 2006

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

scientific article published on 13 September 2009

Initial clinical experience evaluating Yttrium-90-chimeric T84.66 anticarcinoembryonic antigen antibody and autologous hematopoietic stem cell support in patients with carcinoembryonic antigen-producing metastatic breast cancer.

scientific article

Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape

scientific article published on 15 June 2013

Intracerebral CpG immunotherapy with carbon nanotubes abrogates growth of subcutaneous melanomas in mice

scientific article

Intrapatient consistency of imaging biodistributions and their application to predicting therapeutic doses in a phase I clinical study of 90Y-based radioimmunotherapy

scientific article published on May 1999

Intratumoral immunocytokine treatment results in enhanced antitumor effects

scientific article published on 26 April 2008

Low Dose Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells

scientific article

Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications

scientific article published in July 2001

Matched-Cohort Analysis of Autologous Hematopoietic Cell Transplantation with Radioimmunotherapy versus Total Body Irradiation–Based Conditioning for Poor-Risk Diffuse Large Cell Lymphoma ⬇️

scientific article published on July 27, 2011

Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation

scientific article

Metabolism and renal clearance of 111In-labeled DOTA-conjugated antibody fragments

scientific article published in March 2001

Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity ⬇️

scientific article published on February 1, 2010

Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts

scientific article

Modeling of tumor uptake to determine the time-dose-fractionation effect in radioimmunotherapy

scientific article published on 01 September 1994

Monodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET.

scientific article published on 16 June 2010

Monte Carlo-Assisted Voxel Source Kernel Method (MAVSK) for Internal Beta Dosimetry ⬇️

scientific article published on 01 May 1998

Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange

scientific article

New Transplant Strategies Utilizing Radioimmunotherapy (RIT) Based Regimens To Reduce Relapse in High Risk Mantle Cell Lymphoma (MCL). ⬇️

scholarly article

Numerical selection of optimal tumor imaging agents with application to engineered antibodies

scientific article published in February 2001

On the correction for radioactive decay in pharmacokinetic modeling

scientific article published on October 1995

Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains

scientific article published on 01 August 2007

Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging

scientific article

Pharmacokinetic modeling and absorbed dose estimation for chimeric anti-CEA antibody in humans ⬇️

scientific article published on December 1, 1997

Phase I Trial Results Testing Adoptively Transferred T Cells Expressing CD20-Specific Chimeric Antigen Receptors Containing CD28 and CD137 Costimulatory Domains In Patients with Mantle Cell Lymphoma and Indolent Lymphoma ⬇️

scholarly article

Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma

scientific article

Phase I/II Trial of Anticarcinoembryonic Antigen Radioimmunotherapy, Gemcitabine, and Hepatic Arterial Infusion of Fluorodeoxyuridine Postresection of Liver Metastasis for Colorectal Carcinoma.

scientific article published in September 2017

Phase II trial of a transplantation regimen of yttrium-90 ibritumomab tiuxetan and high-dose chemotherapy in patients with non-Hodgkin's lymphoma

scientific article published on 19 November 2007

Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer

scientific article published in August 2004

Preclinical Efficacy of Campthothecin-Polymer Conjugate (IT-101) in Human Burkitt Lymphoma Bearing Mice. ⬇️

scholarly article

Preclinical results of camptothecin-polymer conjugate (IT-101) in multiple human lymphoma xenograft models

scientific article published on 23 June 2009

Quantitative serial imaging of an 124I anti-CEA monoclonal antibody in tumor-bearing mice

scientific article

Quantitative, Simultaneous PET/MRI for Intratumoral Imaging with an MRI-Compatible PET Scanner ⬇️

scientific article published on June 1, 2012

Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy

scientific article published on January 2007

Rapid and efficient production of radiolabeled antibody conjugates using vacuum diafiltration guided by mathematical modeling

scientific article

Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas

scientific article

Reduction of kidney uptake in radiometal labeled peptide linkers conjugated to recombinant antibody fragments. Site-specific conjugation of DOTA-peptides to a Cys-diabody

scientific article published in September 2002

S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

scientific article

Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101

scientific article published on 26 March 2013

Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with improved 64-copper PET imaging

scientific article

Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.

scientific article

T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect

scientific article published on 10 October 2002

T-cell genetic modification for re-directed tumor recognition.

scientific article

TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy

scientific article published on 23 October 2013

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo ⬇️

scientific article published on January 3, 2013

Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.

scientific article

Targeting, imaging, and therapy using a humanized antiprostate stem cell antigen (PSCA) antibody

scientific article published on May 2007

The Novel De-Immunized Anti-CD20-IL-2 Immunocytokine DI-Leu16-IL-2 Is Effective in SCID Mice Bearing Rituximab-Resistant Human Lymphoma Xenografts. ⬇️

scholarly article

The Use of Reduced Intensity Allogeneic Stem Cell Transplantation (alloSCT) for Recurrence after Autologous Stem Cell Transplantation (ASCT) in Hodgkin’s Disease (HD). ⬇️

scholarly article

The two types of correction of absorbed dose estimates for internal emitters.

scientific article

Truncation of blood curves to enhance imaging and therapy with monoclonal antibodies

scientific article published on May 2000

Tumor Uptake of 64Cu-DOTA-Trastuzumab in Patients with Metastatic Breast Cancer.

scientific article published on 21 June 2017

Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers ⬇️

scientific article published on February 1, 1996

Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments

scientific article published on March 2001

Vinyl sulfone bifunctional derivatives of DOTA allow sulfhydryl- or amino-directed coupling to antibodies. Conjugates retain immunoreactivity and have similar biodistributions

scientific article published in January 2002

Y90 Plus High Dose BEAM with Autologous Stem Cell Transplantation for Chemorefractory Non Hodgkin Lymphoma. ⬇️

scholarly article

gamma-Interferon administration after 90yttrium radiolabeled antibody therapy: survival and hematopoietic toxicity studies

scientific article published in February 1995

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