List of works - Christoph Becker-Pauly

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

scientific article published on 22 February 2018

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

scientific article

Calcium negatively regulates meprin β activity and attenuates substrate cleavage

scientific article published on 8 May 2015

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro

scientific article

Degradome of soluble ADAM10 and ADAM17 metalloproteases

scientific article published on 17 June 2019

Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.

scientific article published on 18 January 2016

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.

scientific article

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration

scientific article published on 21 December 2016

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4.

scientific article published on 11 August 2015

Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer

scientific article

Evaluation of ¹¹¹in-labelled exendin-4 derivatives containing different meprin β-specific cleavable linkers

scientific article

Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases

scientific article published on 9 September 2010

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

scientific article published on 19 February 2016

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.

scientific article published on 9 March 2016

Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus

scientific article

LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries

scientific article

Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.

scientific article

Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets

scientific article published on 24 March 2014

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

scientific article published on 09 March 2017

Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis

scientific article published on 11 May 2017

Meprin α and meprin β: Procollagen proteinases in health and disease

scientific article

Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration ⬇️

scientific article published on August 24, 2012

Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo

scientific article

Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis

scientific article

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding

scientific article published on 15 June 2015

Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength

scientific article published on 12 August 2013

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin

scientific article published on 16 December 2016

Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models

scientific article

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

scientific article

News from an ancient world: two novel astacin metalloproteases from the horseshoe crab

scientific article

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography

scientific article published on 3 October 2016

Processing of procollagen III by meprins: new players in extracellular matrix assembly?

scientific article published on 15 July 2010

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

scientific article

Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates

scientific article

Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S.

scientific article

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

scientific article published on 14 June 2019

Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli

scientific article

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

scientific article published on 14 October 2013

Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases

scientific article published on 23 July 2012

Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading

scientific article published on 12 September 2009

Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membrane

scientific article

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections ⬇️

scientific article published on September 1, 2012

TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis

scientific article published on 11 June 2013

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains

scientific article

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.

scientific article published on January 2016

The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation

scientific article

The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1.

scientific article published on May 2006

The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species

scientific article published on 9 August 2012

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis ⬇️

scientific article published on March 1, 2013

The role of interleukin-6 signaling in nervous tissue

scientific article published on 22 March 2016

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.

scientific article published on September 2012

List of works by Christoph Becker-Pauly

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

Calcium negatively regulates meprin β activity and attenuates substrate cleavage

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro

Degradome of soluble ADAM10 and ADAM17 metalloproteases

Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4.

Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer

Evaluation of ¹¹¹in-labelled exendin-4 derivatives containing different meprin β-specific cleavable linkers

Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.

Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus

LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries

Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.

Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

Meprin metalloproteases: Molecular regulation and function in inflammation and fibrosis

Meprin α and meprin β: Procollagen proteinases in health and disease

Meprinα Transactivates the Epidermal Growth Factor Receptor (EGFR) via Ligand Shedding, thereby Enhancing Colorectal Cancer Cell Proliferation and Migration ⬇️

Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo

Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding

Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin

Mice are not Men: ADAM30 Findings Emphasize a Broader Look Towards Murine Alzheimer's Disease Models

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

News from an ancient world: two novel astacin metalloproteases from the horseshoe crab

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography

Processing of procollagen III by meprins: new players in extracellular matrix assembly?

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates

Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S.

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases

Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading

Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membrane

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections ⬇️

TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis

Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.

The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation

The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1.

The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis ⬇️

The role of interleukin-6 signaling in nervous tissue

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.