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List of works by Gerhard Müller-Newen

A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor

scientific article (publication date: June 2002)

A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor

scientific article published on 19 March 2003

A receptor fusion protein for the inhibition of murine oncostatin M ⬇️

scientific article published on January 11, 2011

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms

scientific article published on 14 December 2014

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.

scientific article published in March 2003

An essential role for gp130 in neointima formation following arterial injury

scientific journal article

Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy

scientific article published on 9 June 2015

Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery

scientific article published on October 2015

Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.

scientific article published on 8 April 2014

Assessing the Intracellular Integrity of Phosphine-Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling

scientific article

Barttin modulates trafficking and function of ClC-K channels

scientific article

Biological Activation of Bioinert Medical High Performance Oxide Ceramics by Hydrolytically Stable Immobilization of c(RGDyK) and BMP-2

article

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts

scientific article

Bow to your partner for signaling

scientific article published on 01 June 2005

CLCN2 variants in idiopathic generalized epilepsy

scientific article published on 01 September 2009

Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

scientific article

Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function

scientific article (publication date: 2013)

Characterization of cyclin L1 as an immobile component of the splicing factor compartment

scientific article

Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors

scientific article (publication date: 6 February 2004)

Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins

scientific article published on 3 November 2006

Consequences of the disease-related L78R mutation for dimerization and activity of STAT3

scientific article published on 25 February 2014

Corrigendum: Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-<i>in-Silico</i> Approach Combining <i>In Vitro</i> Experiments and Machine Learning

scientific article published on 10 December 2020

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma

scientific article

Cytokines and inflammation

scientific article published on 23 February 2012

DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules

scientific article published on 30 September 2010

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1)

scientific article published on 01 July 2009

Development of platelets during steady state and inflammation

scientific article published on 24 February 2017

Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells

scientific article published on November 2005

Directed covalent immobilization of fluorescently labeled cytokines.

scientific article

Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3 nuclear trafficking

scientific article

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain

scientific article published on 5 November 2013

Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62.

scientific article

Dynamics and non-canonical aspects of JAK/STAT signalling

scientific article published on 21 October 2011

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

scientific article

Fluorescent SNAP-tag galectin fusion proteins as novel tools in glycobiology.

scientific article published in January 2013

Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism

scientific article published on 26 April 2018

Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells

scientific article (publication date: 12 March 2004)

Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer

scientific article published on 15 November 2005

Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells

scientific article published on 05 March 2020

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

scientific article published on 01 August 2018

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

scientific article published on 13 April 2017

Gp130-dependent signaling in the podocyte

Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning

scientific article published on 20 March 2018

Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis.

scientific article published in March 2004

Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy

scientific article

Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies

scientific article

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

scientific article published on 18 October 2016

JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation

article

Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase

scientific article published on 3 May 2004

Latent MMP-9 is bound to TIMP-1 before secretion

scientific article

Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis

scientific article published on 23 July 2003

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling

scientific article

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis

scientific article

Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes.

scientific article

Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

scientific article (publication date: April 2003)

Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis

scientific article published on 19 August 2013

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis

scientific article published on 15 March 2019

Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors

scientific article published on 3 January 2008

Nuclear translocation of STAT3 and NF-κB are independent of each other but NF-κB supports expression and activation of STAT3.

scientific article published on 9 January 2017

Nucleocytoplasmic Shuttling of STATs. A Target for Intervention?

scientific article published on 19 November 2019

Nucleocytoplasmic shuttling of persistently activated STAT3.

scientific article published on 28 August 2007

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.

scientific article

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

scientific article published on 3 April 2017

Plasticity and cross-talk of interleukin 6-type cytokines

scientific article published on 15 May 2012

Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury

scientific article published on 19 July 2010

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

scientific article

Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo

scientific article published on 18 November 2020

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

scientific article published on 10 February 2016

Real time analysis of STAT3 nucleocytoplasmic shuttling

scientific article published on 29 December 2003

Receptor fusion proteins for the inhibition of cytokines ⬇️

scientific article published on September 29, 2011

Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

scientific article published on 01 September 2009

Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis

scientific article published on 26 March 2020

STAT3 is enriched in nuclear bodies

scientific article published on 2 December 2003

Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes

scientific article published on 29 October 2015

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

scientific article published on 2 December 2010

Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction

scientific article published on 15 February 2015

Stem cell persistence in CML is mediated by extrinsically activated JAK1-STAT3 signaling

scientific article published on 06 March 2019

Surface Topography Guides Morphology and Spatial Patterning of Induced Pluripotent Stem Cell Colonies

scientific article

Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft-versus-host disease

scientific article published on 20 October 2015

The Cytokine Receptor gp130: Faithfully Promiscuous ⬇️

scientific article published on September 23, 2003

The Impact of Plasma-Derived Microvesicles From a Femoral Fracture Animal Model on Osteoblast Function

scientific article published on 01 January 2020

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3.

scientific article published on 15 February 2011

The role of the carboxyl terminus in ClC chloride channel function

scientific article published on 12 January 2004

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling ⬇️

scientific article published on March 1, 2004

The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum

scientific article published on 13 September 2016

Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis.

scientific article

Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation ⬇️

scientific article published on November 16, 2012

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

scientific article published on 19 September 2019

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