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List of works by Ajit Varki

Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model

scientific article

Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling

scientific article

Are humans prone to autoimmunity? Implications from evolutionary changes in hominin sialic acid biology.

scientific article published on 26 July 2017

Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid.

scientific article

Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

scientific article

Colloquium paper: uniquely human evolution of sialic acid genetics and biology

scientific article

Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant

scientific article published on 22 August 2019

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils

scientific article

Discovery and characterization of sialic acid O-acetylation in group B Streptococcus

scientific article published on 19 July 2004

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing

scientific article published on 25 March 2019

Evolution of host adaptation in the Salmonella typhoid toxin

scientific article published on 9 October 2017

Evolution of siglec-11 and siglec-16 genes in hominins

scientific article

Evolution of the exclusively human pathogen : Human-specific engagement of immunoregulatory Siglecs

scientific article published on 03 January 2019

Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae

scientific article published in 2021

Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution

scientific article

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

scientific article

Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact

scientific article published on 30 July 2009

Genomic Comparisons of Humans and Chimpanzees

scientific article

Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes

scientific article published on 22 September 2006

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates

scientific article published on 23 September 2019

Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

scientific article

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera.

scientific article

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

scientific paper published in 2019

Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid ⬇️

scientific article published on October 14, 2003

Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution

scientific article published on 12 September 2018

Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution

scientific article

Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure

scholarly article

Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms

scientific article

Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State

scientific article published on February 2017

Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid

scientific article

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

scientific article published on 04 February 2009

NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus

scientific article published on 23 July 2007

O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence

scientific article published on 13 May 2010

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

scientific article published on 18 January 2017

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.

scientific article published on 18 June 2018

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates

scientific article

Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via CMAH loss

scientific article published on 21 January 2020

Sequencing the chimpanzee genome: insights into human evolution and disease

scientific article

Sialyltransferase ST3Gal-III Regulates Siglec-F Ligand Formation and Eosinophilic Lung Inflammation in Mice ⬇️

scientific article published on May 15, 2013

Specific inactivation of two immunomodulatory SIGLEC genes during human evolution

scientific article

Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis

scientific article

Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract

scientific article

The 1999 ASCI Presidential Address: Executive Summary of the Nerflex Commission Report

scientific article

The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters.

scientific article published on 20 February 2006

Therapeutic CMP-Nonulosonates against Multidrug-Resistant Neisseria gonorrhoeae

scientific article published on 20 May 2020

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus.

scientific article published on 19 December 2017

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