List of works - Manu Lopus

9-PAN promotes tubulin- and ROS-mediated cell death in human triple-negative breast cancer cells

scientific article published on 16 August 2020

A molecular and structural mechanism for G protein-mediated microtubule destabilization.

scientific article

Analysis of dynamic instability of steady-state microtubules in vitro by video-enhanced differential interference contrast microscopy with an appendix by Emin Oroudjev

scientific article

Antibody-DM1 conjugates as cancer therapeutics.

scientific article

Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.

scientific article published on 23 April 2015

Cell death mechanisms in eukaryotes

scientific article published on 09 December 2019

Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents

scientific article published on 9 July 2016

Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends.

scientific article published on 28 March 2012

Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents

scientific article published on 31 March 2015

Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma

scientific article published on 3 March 2006

Editorial:Tubulin-targeted Cancer Chemotherapeutics: Advances and Challenges.

scientific article

Effects of eribulin on microtubule binding and dynamic instability are strengthened in the absence of the βIII tubulin isotype

scientific article

Elucidation of the Tubulin-targeted Mechanism of Action of 9-(3-pyridyl) Noscapine.

scientific article published on 4 January 2017

Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol.

scientific article published on 14 December 2016

From Natural Products to Designer Drugs: Development and Molecular Mechanisms Action of Novel Anti-Microtubule Breast Cancer Therapeutics.

scientific article published on 4 January 2017

In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).

scientific article

Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells.

scientific article published on 07 December 2016

Insights into the structure and tubulin-targeted anticancer potential of N-(3-bromobenzyl) noscapine

scientific article published on 06 September 2018

Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules

scientific article

Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.

scientific article published on October 2010

Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype

scientific article

Perturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability

scientific article published on 06 August 2019

Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents

scientific article

Rational design of the microtubule-targeting anti-breast cancer drug EM015.

scientific article published on April 2006

Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents

scientific article (publication date: 2013)

Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules

scientific article published on 11 October 2017

Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations.

scientific article published on 31 August 2016

Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.

scientific article published on 10 May 2006

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics.

scientific article

The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity.

scientific article published on May 2006

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

scientific article

Tryptone-stabilized gold nanoparticles induce unipolar clustering of supernumerary centrosomes and G1 arrest in triple-negative breast cancer cells

scientific article published on 13 December 2019

Tryptone-stabilized gold nanoparticles target tubulin and inhibit cell viability by inducing an unusual form of cell cycle arrest

scientific article published on 5 September 2017

List of works by Manu Lopus

9-PAN promotes tubulin- and ROS-mediated cell death in human triple-negative breast cancer cells

A molecular and structural mechanism for G protein-mediated microtubule destabilization.

Analysis of dynamic instability of steady-state microtubules in vitro by video-enhanced differential interference contrast microscopy with an appendix by Emin Oroudjev

Antibody-DM1 conjugates as cancer therapeutics.

Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.

Cell death mechanisms in eukaryotes

Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents

Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends.

Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents

Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma

Editorial:Tubulin-targeted Cancer Chemotherapeutics: Advances and Challenges.

Effects of eribulin on microtubule binding and dynamic instability are strengthened in the absence of the βIII tubulin isotype

Elucidation of the Tubulin-targeted Mechanism of Action of 9-(3-pyridyl) Noscapine.

Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol.

From Natural Products to Designer Drugs: Development and Molecular Mechanisms Action of Novel Anti-Microtubule Breast Cancer Therapeutics.

In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).

Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells.

Insights into the structure and tubulin-targeted anticancer potential of N-(3-bromobenzyl) noscapine

Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules

Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.

Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype

Perturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability

Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents

Rational design of the microtubule-targeting anti-breast cancer drug EM015.

Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents

Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules

Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations.

Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics.

The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding. A possible mechanism for its antiproliferative activity.

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

Tryptone-stabilized gold nanoparticles induce unipolar clustering of supernumerary centrosomes and G1 arrest in triple-negative breast cancer cells

Tryptone-stabilized gold nanoparticles target tubulin and inhibit cell viability by inducing an unusual form of cell cycle arrest