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List of works by Claudio Trapella

1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (Compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices

scientific article published in February 2009

1-cyclohexyl-x-methoxybenzene derivatives, novel psychoactive substances seized on the internet market. Synthesis and in vivo pharmacological studies in mice.

scientific article

6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

scientific article published in June 2006

A Convenient Route to Enantiomerically Pure 2-Substituted Methyl Glycerate Derivatives

scientific article published in 2003

A Linear Allergic Contact Dermatitis to p-tert-Butylphenol Formaldehyde Resin Sectorially Present in a Neoprene Orthopedic Brace

scientific article published on 01 November 2012

A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism

scientific article

A new amido-phosphine of dichloroacetic acid as an active ligand for metals of pharmaceutical interest. Synthesis, characterization and tests of antiproliferative and pro-apoptotic activity

scientific article published on 22 July 2019

A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic

scientific article

A new synthetic approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one(J-113397), the first non-peptide ORL-1 receptor antagonist..

scientific article

A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.

scientific article published on 13 May 2014

Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats

scholarly article by Laura Micheli et al published May 2015 in European Journal of Pharmacology

Antinociceptive action of NOP and opioid receptor agonists in the mouse orofacial formalin test

scientific article published on 8 July 2017

Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist.

scientific article

Bile Acid Binding Protein Functionalization Leads to a Fully Synthetic Rhodopsin Mimic

scientific article published on 22 April 2019

Biochemically Controlled Release of Dexamethasone Covalently Bound to PEDOT

scientific article published on 25 June 2018

C-terminaltrans,trans-muconic acid ethyl ester partial retro-inverso pseudopeptides as proteasome inhibitors

scientific article published on 07 August 2012

Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor

scientific article published on 15 August 2007

Correction for Bortolotti et al., "Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells".

scientific article published on 17 November 2017

Design and Synthesis of TcN-Labeled Dextran-Mannose Derivatives for Sentinel Lymph Node Detection

scholarly article by Alessandra Boschi et al published 16 July 2018 in Pharmaceuticals

Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity

scientific article published on 11 December 2015

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands.

scientific article published on 13 February 2015

Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction

scientific article published on 09 August 2018

Dopamine–nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: Involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity

scientific article published on 06 January 2011

Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice

scientific article published on 15 January 2016

Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.

scientific article published on September 2006

Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.

scientific article published on 15 August 2016

Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: Pharmacological and genetic evidences

article

Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid Pharmacophore

scientific article

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists

scientific article published on July 2009

Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic

scientific article

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.

scientific article published on 22 February 2007

Further studies on the pharmacological features of the nociceptin/orphanin FQ receptor ligand ZP120

scientific article published on 17 October 2008

Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.

scientific article

Glutamine vinyl ester proteasome inhibitors selective for trypsin-like (β2) subunit

scientific article published on 09 January 2007

HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts

scientific article published in Scientific Reports

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

scientific article published on 3 October 2005

In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.

scientific article

In vitro and in vivo pharmacological characterization of the novel neuropeptide S receptor ligands QA1 and PI1.

scientific article published on 30 July 2013

In vitro pharmacological characterization of a novel unbiased NOP receptor-selective nonpeptide agonist AT-403.

scientific article published in August 2017

Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore

scientific article

Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity

scientific article published on 5 October 2015

JWH-018 impairs sensorimotor functions in mice.

scientific article published on 15 May 2015

Letter to the Editor: Antimicrobial properties of mucus from the brown garden snail Helix aspersa

scientific article published on 01 January 2016

N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands

scientific article published in March 2005

N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis

scientific article published on 14 May 2014

NOP agonist action of cebranopadol counteracts its liability to promote physical dependence

scientific article published on 12 December 2018

NOP receptor pharmacological profile - A dynamic mass redistribution study

scientific article published in PLoS ONE

Naphthoquinone amino acid derivatives, synthesis and biological activity as proteasome inhibitors.

scientific article

Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice

scientific article published on 27 August 2018

Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor.

scientific article

Neuropeptide S receptor ligands: a patent review (2005-2016).

scientific article

Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor

scientific article

New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands

scientific article

New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting

scientific article published on 15 May 2018

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores

scientific article published on September 2006

Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.

scientific article

Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways.

scientific article

Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity.

scientific article

Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice

scientific article published on 11 March 2015

Novel halogenated synthetic cannabinoids impair sensorimotor functions in mice

scientific article published on 11 October 2019

P3 and P4 position analysis of vinyl ester pseudopeptide proteasome inhibitors.

scientific article published on 5 April 2006

Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.

scientific article published on 6 August 2015

Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

scientific article published on 02 August 2016

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies.

scientific article published on 28 February 2007

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies.

scientific article published on 28 February 2007

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

scientific article published on 12 May 2009

Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis

scientific article published on 06 May 2020

Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5.

scientific article published on 28 January 2009

Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex

scientific article published in March 2004

Physicochemical stability of cabazitaxel and docetaxel solutions

Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells

scientific article published on 20 July 2015

Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502)

scientific article published on 23 December 2007

Sometimes, the Least Demanding Solution Is the Most Suitable: A Careful Survey of NMR Spectra of a Phosphonium Salt Accounted for Its “Unusual Wittig Reaction”

scientific article published on 19 July 2018

Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5.

scientific article

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

scientific article

Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands

scientific article published on 06 April 2017

Structure-Activity Relationship Studies on Oxazolo[3,4-<i>a</i>]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent <i>In Vivo</i> Activity

scientific article published on 18 March 2021

Structure-activity relationship study of position 4 in the urotensin-II receptor ligand U-II(4-11).

scientific article published on 31 July 2007

Structure-activity relationship study on Tyr9 of urotensin-II(4-11): identification of a partial agonist of the UT receptor

scientific article

Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation

scientific article

Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.

scientific article published on 2 June 2009

Structure-activity study at positions 3 and 4 of human neuropeptide S.

scientific article

Studies of C-terminal naphthoquinone dipeptides as 20S proteasome inhibitors.

scientific article published on 5 May 2015

Synthesis and activity of isoxazoline vinyl ester pseudopeptides as proteasome inhibitors

scientific article published on 01 April 2014

Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

scientific article

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

scientific article

Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids

scientific article published on 24 April 2007

Synthesis and biological evaluation of new vinyl ester pseudotripeptide proteasome inhibitors

scientific article published on 18 May 2006

Synthesis and biological properties of C-terminal vinyl ketone pseudotripeptides

scientific article published on 01 March 2012

Synthesis and proteasome inhibition of N-allyl vinyl ester-based peptides.

scientific article published on November 2010

Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).

scientific article

Synthetic cannabinoid JWH-018 and its halogenated derivatives JWH-018-Cl and JWH-018-Br impair Novel Object Recognition in mice: Behavioral, electrophysiological and neurochemical evidence.

scientific article published on 23 June 2016

The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor

scientific article

The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway.

scientific article published in February 2007

The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA.

scientific article published on 5 November 2008

Triazine compounds as antagonists at Bv8-prokineticin receptors

scientific article

Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

scientific article published in July 2005

[d-Pen(p- t BuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies

scholarly article by Chiara Ruzza et al published 11 February 2014 in Medicinal Chemistry Research

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