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List of works by Yuk Y. Sham

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase ⬇️

scientific article published on March 7, 2011

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

scientific article

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase ⬇️

scientific article published on February 18, 2011

A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.

scientific article

A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

scientific article published on 5 December 2006

A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

scientific article

A universal method for the preparation of covalent protein-DNA conjugates for use in creating protein nanostructures

scientific article published on 01 January 2007

All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions

scientific article published on 19 October 2017

An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules

scientific article published on 09 August 2018

Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases

scientific article published on 12 September 2016

CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy

scientific article published on 17 October 2019

Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation?

scientific article published on 11 January 2018

Cell permeable vanX inhibitors as vancomycin re-sensitizing agents

scientific article published on 08 April 2014

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization

scientific article published on 24 May 2017

Design and synthesis of sulfoximine based inhibitors for HIV-1 protease.

scientific article published on 13 September 2008

Design, asymmetric synthesis, and evaluation of pseudosymmetric sulfoximine inhibitors against HIV-1 protease

scientific article published on 21 January 2010

Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation

scientific article published on 01 March 2007

Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor

scientific article published on 8 May 2017

Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.

scientific article published on 26 July 2015

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

scientific article published on July 2010

Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system.

scientific article published in May 2005

Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity

scientific article published on 16 October 2007

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

scientific article

Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation

scientific article published on 08 October 2018

Modeling and Simulation of GAT1: A Mechanistic Investigation of the GABA Transport Process

Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues

scientific article

Mosquito salivary allergen Aed a 3: cloning, comprehensive molecular analysis, and clinical evaluation

scientific article published on 26 November 2015

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

scientific article published on 10 October 2018

Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking.

scientific article published on 23 October 2013

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase

scientific article

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

scientific article

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

scientific article published on 01 September 2019

Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level

scientific article published on 05 November 2004

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search

scientific article published on 17 January 2014

Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines

scientific article

The Effect of Protein Relaxation on Charge-Charge Interactions and Dielectric Constants of Proteins ⬇️

scientific article published on April 1, 1998

The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli

scientific article published on 18 January 2017

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus ⬇️

scientific article published on October 24, 2011

Thermal unfolding molecular dynamics simulation of Escherichia coli dihydrofolate reductase: thermal stability of protein domains and unfolding pathway

scientific article published on February 2002

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.

scientific article published in April 2018

Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis

scientific journal article

pH-Dependent Transport of Pemetrexed by Breast Cancer Resistance Protein ⬇️

scientific article published on May 31, 2011

pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.

scientific article published on 3 April 2012

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