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List of works by James R. Baker

A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy

scientific article

A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics

scientific article published on 02 March 2020

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging

scientific article published on 01 October 2015

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

scientific article published on July 2013

A one-step procedure for the monoacylation of symmetrical 1,2-diols

scientific article published in July 2002

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.

scientific article published on 25 June 2015

Acid-catalyzed rearrangement of fused alkylideneoxetanols

scientific article published on 16 October 2007

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.

scientific article published on September 2013

An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.

scientific article published on 30 April 2010

An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore

scientific article published on 01 January 2007

Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

scientific article published on 01 July 2014

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents

scientific article published on 01 January 2014

Bromomaleimide-linked bioconjugates are cleavable in mammalian cells

scientific article published on 18 November 2011

Bromopyridazinedione-mediated protein and peptide bioconjugation ⬇️

scientific article published on July 7, 2011

Cysteine-to-lysine transfer antibody fragment conjugation

scientific article published on 11 October 2019

Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions

scientific article published on 18 March 2019

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

scientific article

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

scientific article published on 05 June 2015

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

scientific article published on 21 March 2012

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.

scientific article

Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.

scientific article published on January 2013

Homogeneous bispecifics by disulfide bridging.

scientific article published on August 2014

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation ⬇️

scientific article published on January 27, 2011

In situ reduction in photocycloadditions: a method to prevent secondary photoreactions

scientific article published on 01 February 2009

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

scientific article published on October 2014

Next-generation disulfide stapling: reduction and functional re-bridging all in one.

scientific article published on 15 September 2015

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

scientific article published on 14 March 2017

Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers

scientific article published on 01 August 2019

Photo-antagonism of the GABAA receptor.

scientific article

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines

scientific article published on 01 January 2016

Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents

scientific article published on 13 January 2012

Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.

scientific article published in May 2007

Rapid access to azepine-fused oxetanols from alkoxy-substituted maleimides

scientific article published on 01 April 2004

Reversible protein affinity-labelling using bromomaleimide-based reagents ⬇️

scientific article published on March 5, 2013

Synthesis and [2+2]-photodimerisation of monothiomaleimide functionalised linear and brush-like polymers

scientific article published on 21 July 2020

Synthesis and evaluation of highly potent GABA(A) receptor antagonists based on gabazine (SR-95531)

scientific article published on 25 May 2011

Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore

scientific article published on 3 October 2007

The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.

scientific article

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis ⬇️

scientific article published on April 5, 2011

Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs

scientific article published on 31 January 2018

[2+2] photocycloadditions of thiomaleimides

scientific article published on 04 April 2012

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