List of works - Sascha Flohé

A combined trauma model of chest and abdominal trauma with hemorrhagic shock--description of a new porcine model

scientific article published on 01 December 2012

A wheat-based, diabetes-promoting diet induces a Th1-type cytokine bias in the gut of NOD mice

scientific article published in February 2003

ATLS-certified physicians and outcome from trauma

scientific article published on 16 July 2011

Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation.

scientific article

Analysis of intragraft cytokine expression during early reperfusion after liver transplantation using semi-quantitative RT-PCR.

scientific article published in June 1998

Coagulation management of bleeding trauma patients is changing in German trauma centers: an analysis from the trauma registry of the German Society for Trauma Surgery

scientific article published in April 2012

Comparison of two different matrix-based autologous chondrocyte transplantation systems: 1 year follow-up results.

scientific article

Cytokine synthesis in the liver of endotoxin-tolerant and normal rats during hemorrhagic shock

scientific article published on 01 January 2001

Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge

scientific article

Deoxyribonuclease is a potential counter regulator of aberrant neutrophil extracellular traps formation after major trauma

scientific article published on 23 January 2012

Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice

scientific article published on 26 July 2012

Differential immunostimulating effect of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and interferon gamma (IFNgamma) after severe trauma

scientific article published on 01 January 2007

Diverse regulatory activity of human heat shock proteins 60 and 70 on endotoxin-induced inflammation

scientific article published on 30 May 2007

Effect of granulocyte-macrophage colony-stimulating factor on the immune response of circulating monocytes after severe trauma

scientific article published in October 2003

Effects of Lewisite on cell membrane integrity and energy metabolism in human keratinocytes and SCL II cells.

scientific article

Effects of endotoxin tolerance on liver function after hepatic ischemia/reperfusion injury in the rat

scientific article published on 01 January 2002

Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 AND HSP 70 in lung and liver during endotoxin shock

scientific article published on 01 October 1999

Endotoxin tolerance protects against local hepatic ischemia/reperfusion injury in the rat

scientific article published on 01 January 2000

Essential measures for prehospital treatment of severely injured patients: The trauma care bundle

scientific article published on 10 July 2015

Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis

scientific article published on 01 September 2006

Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation

scientific article published on 01 January 1998

Facts and fiction: the impact of hypothermia on molecular mechanisms following major challenge

scientific article

GM-CSF counteracts hemorrhage-induced suppression of cytokine-producing capacity.

scientific article published in January 2004

GM-CSF priming of human monocytes is dependent on ERK1/2 activation

scientific article published in January 2006

Granulocyte-Macrophage Colony-Stimulating Factor (GM‐CSF) Restores Decreased Monocyte HLA‐DR Expression after Cardiopulmonary Bypass

scientific article published on 01 February 2007

HLA-DR monitoring in the intensive care unit--more than a tool for the scientist in the laboratory?

scientific article published in October 2009

Haemorrhagic shock in mice--intracellular signalling and immunomodulation of peritoneal macrophages' LPS response

scientific article published on 13 June 2006

How to define severely injured patients? -- an Injury Severity Score (ISS) based approach alone is not sufficient

scientific article published in October 2014

Immunological reactions secondary to blood transfusion.

scientific article

Implant-associated localized osteitis in murine femur fracture by biofilm forming Staphylococcus aureus: a novel experimental model

scientific article published on 22 July 2013

Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis

scientific article published on 13 January 2011

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

scientific article published on 11 June 2015

Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model: Retracted ⬇️

scientific article published on 6 April 2016

Induced hypothermia does not impair coagulation system in a swine multiple trauma model.

scientific article published in April 2013

Induced hypothermia reduces the hepatic inflammatory response in a swine multiple trauma model

scientific article published in June 2014

Influence of granulocyte-macrophage colony-stimulating factor (GM-CSF) on whole blood endotoxin responsiveness following trauma, cardiopulmonary bypass, and severe sepsis

scientific article published on 01 July 1999

Influence of surgical intervention in the immune response of severely injured patients

scientific article published on 07 November 2003

Initial treatment of severely injured patients: A challenge for trauma surgery

scientific article published on 2 July 2015

Intensive care medicine -- update 2004

scientific article published in June 2005

Intensive care medicine -- update 2005

scientific article published in June 2006

Intensive medicine criteria for operability

scientific article published in October 2005

Interferon-gamma counteracts reduced endotoxin responsiveness of whole blood following trauma and cardiopulmonary bypass

scientific article published on 01 January 2000

Interhospital transfer of severely injured patients in Germany. Evaluation of the DGU trauma register

scientific article published in August 2012

Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms

scientific article published on December 2008

Kynurenine inhibits chondrocyte proliferation and is increased in synovial fluid of patients with septic arthritis ⬇️

scientific article published on November 1, 2010

Level of Evidence Analysis for the Latest German National Guideline on Treatment of Patients with Severe and Multiple Injuries and ATLS.

scientific article published in August 2015

Limited volume resuscitation in hypotensive elderly multiple trauma is safe and prevents early clinical dilutive coagulopathy -- a matched-pair analysis from TraumaRegister DGU(®).

scientific article published in October 2014

Lysostaphin-coated titan-implants preventing localized osteitis by Staphylococcus aureus in a mouse model

scientific article

Microcirculatory alterations of hepatic and mesenteric microcirculation in endotoxin tolerance

scientific article published on 01 February 2008

Modification of immune response after polytrauma and cardiopulmonary bypass by hematopoietic growth factors

scientific article published in January 1998

Molecular mechanisms underlying delayed apoptosis in neutrophils from multiple trauma patients with and without sepsis

scientific article

New aspects of polytrauma treatment - current facts and developments: report of the first annual conference of the Committee on Emergency Medicine, Intensive Care and Trauma Management (Sektion NIS)

scientific article published in November 2013

New oral anticoagulants. Relevance for orthopedics and trauma surgery ⬇️

scientific article published on January 1, 2013

Nonoperative management of tracheobronchial injuries in severely injured patients

scientific article published on 01 January 2005

Posttraumatic immune response and its modulation.

scientific article published on 27 March 2012

Preclinical and intrahospital management of mass casualties and terrorist incidents

scientific article published in October 2017

Reconstruction of septic diaphyseal bone defects with the induced membrane technique.

scientific article

Regulation of cytokine synthesis in cardiac surgery: Role of extracorporeal circuit and humoral mediators in vivo and in vitro

scientific article published on 01 March 2007

Relation of a TNF gene polymorphism to severe sepsis in trauma patients

scientific article published on 01 August 1999

Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis

scientific article published on 01 February 1999

Relevance of induced and accidental hypothermia after trauma-haemorrhage-what do we know from experimental models in pigs?

scientific article published on 15 May 2014

Stabilization of chronic proximal tibiofibular joint instability with a semitendinosus graft

scientific article published on 01 December 2010

Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation

scientific article published on 26 August 2015

Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS

scientific article published on 19 August 2010

Surgical Management of Proximal Interphalangeal Joint Repetitive Stress Epiphyseal Fracture Nonunion in Elite Sport Climbers

scientific article

The impact of arterial hypertension on polytrauma and traumatic brain injury.

scientific article

Time course of various inflammatory mediators during recurrent endotoxemia.

scientific article published in May 1992

Tracer diagnosis severe injury/polytrauma in key issue paper 2016

scientific article published on 18 October 2016

Tumor necrosis factor-alpha production in whole blood after cardiopulmonary bypass: downregulation caused by circulating cytokine-inhibitory activities

scientific article published in September 2002

Wheat gluten causes dendritic cell maturation and chemokine secretion.

scientific article

[Clinical course and prognostic significance of immunological and functional parameters after severe trauma]

scientific article published on 01 March 2004

[Complex surgical procedures in orthopedics and trauma surgery. A contribution to the proposal procedure for the DRG system in 2009]

scientific article published on 01 October 2008

[Current practice in coagulation and transfusion therapy in multiple trauma patients: A German nation-wide online survey]

scientific article published on 01 December 2015

[Current standard of care for initial management of open fractures in emergency departments : A nationwide survey in German trauma centers]

scientific article published on 01 August 2016

[Definition of polytrauma in the German DRG system 2006. Up to 30% "incorrect classifications"]

scientific article published on 01 July 2007

[Endotoxin tolerance and hemorrhagic shock in rats]

scientific article

[Fractures of the patella]

scientific article published on 01 May 2010

[Fractures of the shaft of the femur]

scientific article published on 01 July 2009

[Interruption of the diagnostic algorithm and immediate surgical intervention after major trauma--incidence and clinical relevance. Analysis of the Trauma Register of the German Society for Trauma Surgery]

scientific article published on 01 October 2010

[New aspects of treatment of the severely injured. Report on the second annual conference of the Committee on Emergency Medicine, Intensive Care and Trauma Management (Sektion NIS)].

scientific article published in July 2013

[Platelet-rich plasma combined with autologous cancellous bone : An alternative therapy for persistent non-union?]

scientific article published on 01 November 2011

[Recommendations for Releasing the Pelvic Binder After a Non-Invasive Pelvic Stabilisation Procedure Under Emergency Room Conditions]

scientific article published on 13 June 2016

[Significance of liver trauma for the incidence of sepsis, multiple organ failure and lethality of severely injured patients. An organ-specific evaluation of 24,771 patients from the trauma register of the DGU]

scientific article published on 01 April 2008

[Surgical management of life-threatening injuries]

scientific article published on 01 October 2009

List of works by Sascha Flohé

A combined trauma model of chest and abdominal trauma with hemorrhagic shock--description of a new porcine model

A wheat-based, diabetes-promoting diet induces a Th1-type cytokine bias in the gut of NOD mice

ATLS-certified physicians and outcome from trauma

Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation.

Analysis of intragraft cytokine expression during early reperfusion after liver transplantation using semi-quantitative RT-PCR.

Coagulation management of bleeding trauma patients is changing in German trauma centers: an analysis from the trauma registry of the German Society for Trauma Surgery

Comparison of two different matrix-based autologous chondrocyte transplantation systems: 1 year follow-up results.

Cytokine synthesis in the liver of endotoxin-tolerant and normal rats during hemorrhagic shock

Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge

Deoxyribonuclease is a potential counter regulator of aberrant neutrophil extracellular traps formation after major trauma

Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice

Differential immunostimulating effect of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and interferon gamma (IFNgamma) after severe trauma

Diverse regulatory activity of human heat shock proteins 60 and 70 on endotoxin-induced inflammation

Effect of granulocyte-macrophage colony-stimulating factor on the immune response of circulating monocytes after severe trauma

Effects of Lewisite on cell membrane integrity and energy metabolism in human keratinocytes and SCL II cells.

Effects of endotoxin tolerance on liver function after hepatic ischemia/reperfusion injury in the rat

Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 AND HSP 70 in lung and liver during endotoxin shock

Endotoxin tolerance protects against local hepatic ischemia/reperfusion injury in the rat

Essential measures for prehospital treatment of severely injured patients: The trauma care bundle

Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis

Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation

Facts and fiction: the impact of hypothermia on molecular mechanisms following major challenge

GM-CSF counteracts hemorrhage-induced suppression of cytokine-producing capacity.

GM-CSF priming of human monocytes is dependent on ERK1/2 activation

Granulocyte-Macrophage Colony-Stimulating Factor (GM‐CSF) Restores Decreased Monocyte HLA‐DR Expression after Cardiopulmonary Bypass

HLA-DR monitoring in the intensive care unit--more than a tool for the scientist in the laboratory?

Haemorrhagic shock in mice--intracellular signalling and immunomodulation of peritoneal macrophages' LPS response

How to define severely injured patients? -- an Injury Severity Score (ISS) based approach alone is not sufficient

Immunological reactions secondary to blood transfusion.

Implant-associated localized osteitis in murine femur fracture by biofilm forming Staphylococcus aureus: a novel experimental model

Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model: Retracted ⬇️

Induced hypothermia does not impair coagulation system in a swine multiple trauma model.

Induced hypothermia reduces the hepatic inflammatory response in a swine multiple trauma model

Influence of granulocyte-macrophage colony-stimulating factor (GM-CSF) on whole blood endotoxin responsiveness following trauma, cardiopulmonary bypass, and severe sepsis

Influence of surgical intervention in the immune response of severely injured patients

Initial treatment of severely injured patients: A challenge for trauma surgery

Intensive care medicine -- update 2004

Intensive care medicine -- update 2005

Intensive medicine criteria for operability

Interferon-gamma counteracts reduced endotoxin responsiveness of whole blood following trauma and cardiopulmonary bypass

Interhospital transfer of severely injured patients in Germany. Evaluation of the DGU trauma register

Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms

Kynurenine inhibits chondrocyte proliferation and is increased in synovial fluid of patients with septic arthritis ⬇️

Level of Evidence Analysis for the Latest German National Guideline on Treatment of Patients with Severe and Multiple Injuries and ATLS.

Limited volume resuscitation in hypotensive elderly multiple trauma is safe and prevents early clinical dilutive coagulopathy -- a matched-pair analysis from TraumaRegister DGU(®).

Lysostaphin-coated titan-implants preventing localized osteitis by Staphylococcus aureus in a mouse model

Microcirculatory alterations of hepatic and mesenteric microcirculation in endotoxin tolerance

Modification of immune response after polytrauma and cardiopulmonary bypass by hematopoietic growth factors

Molecular mechanisms underlying delayed apoptosis in neutrophils from multiple trauma patients with and without sepsis

New aspects of polytrauma treatment - current facts and developments: report of the first annual conference of the Committee on Emergency Medicine, Intensive Care and Trauma Management (Sektion NIS)

New oral anticoagulants. Relevance for orthopedics and trauma surgery ⬇️

Nonoperative management of tracheobronchial injuries in severely injured patients

Posttraumatic immune response and its modulation.

Preclinical and intrahospital management of mass casualties and terrorist incidents

Reconstruction of septic diaphyseal bone defects with the induced membrane technique.

Regulation of cytokine synthesis in cardiac surgery: Role of extracorporeal circuit and humoral mediators in vivo and in vitro

Relation of a TNF gene polymorphism to severe sepsis in trauma patients

Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis

Relevance of induced and accidental hypothermia after trauma-haemorrhage-what do we know from experimental models in pigs?

Stabilization of chronic proximal tibiofibular joint instability with a semitendinosus graft

Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation

Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS

Surgical Management of Proximal Interphalangeal Joint Repetitive Stress Epiphyseal Fracture Nonunion in Elite Sport Climbers

The impact of arterial hypertension on polytrauma and traumatic brain injury.

Time course of various inflammatory mediators during recurrent endotoxemia.

Tracer diagnosis severe injury/polytrauma in key issue paper 2016

Tumor necrosis factor-alpha production in whole blood after cardiopulmonary bypass: downregulation caused by circulating cytokine-inhibitory activities

Wheat gluten causes dendritic cell maturation and chemokine secretion.

[Clinical course and prognostic significance of immunological and functional parameters after severe trauma]

[Complex surgical procedures in orthopedics and trauma surgery. A contribution to the proposal procedure for the DRG system in 2009]

[Current practice in coagulation and transfusion therapy in multiple trauma patients: A German nation-wide online survey]

[Current standard of care for initial management of open fractures in emergency departments : A nationwide survey in German trauma centers]

[Definition of polytrauma in the German DRG system 2006. Up to 30% "incorrect classifications"]

[Endotoxin tolerance and hemorrhagic shock in rats]

[Fractures of the patella]

[Fractures of the shaft of the femur]

[Interruption of the diagnostic algorithm and immediate surgical intervention after major trauma--incidence and clinical relevance. Analysis of the Trauma Register of the German Society for Trauma Surgery]