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List of works by Kaikobad Irani

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality

scientific article published on 19 February 2018

A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells.

scientific article published on June 1998

A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression

scientific article

APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.

scientific article

APE1/Ref-1: versatility in progress

scientific article published on 01 March 2009

Abnormal CD161+ immune cells and retinoic acid receptor-related orphan receptor γt-mediate enhanced IL-17F expression in the setting of genetic hypertension.

scientific article published on 13 January 2017

Activation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C.

scientific article

Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.

scientific article published in December 2005

Angiotensin II-stimulated vascular remodeling: the search for the culprit oxidase.

scientific article

Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.

scientific article

Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone.

scientific article

Bcl-2 regulates nonapoptotic signal transduction: inhibition of c-Jun N-terminal kinase (JNK) activation by IL-1 beta and hydrogen peroxide.

scientific article published on May 1998

CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.

scientific article published on 23 February 2018

CR6-Interacting Factor 1 Deficiency Impairs Vascular Function by Inhibiting the Sirt1-Endothelial Nitric Oxide Synthase Pathway

scientific article published on 24 January 2017

CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

scientific article

Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.

scientific article

Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence.

scientific article published on January 2003

Crippling of Krüppel (-like factor 2) by bad flow portends a miRky day for endothelial function

scientific article published on 01 August 2011

Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2+ oscillations in human aortic endothelial cells stimulated by histamine.

scientific article published in July 2002

Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells.

scientific article published on 24 June 2013

Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths

scientific article (publication date: 2011)

Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity.

scientific article published on 23 October 2017

Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction

scientific article

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.

scientific article published on 28 July 2016

Establishment of a T-Ag and NF-kappaB binding elements gene co-transfected stable HUVECs cell line

scientific article published on 01 August 2003

Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism.

scientific article published in October 1998

Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway.

scientific article

G protein-coupled receptor G2A: friend or foe of the vasculature?

scientific article published in March 2007

GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension.

scientific article published on 25 June 2013

Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.

scientific article

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc.

scientific article published on 20 September 2011

Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.

scientific article

IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function.

scientific article published on 16 February 2016

Improved hepatic regeneration with reduced injury by redox factor-1 in a rat small-sized liver transplant model.

scientific article

Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction

scientific journal article

Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.

scientific article published in May 2003

Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo

scientific article published on 01 February 2000

Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.

scientific article published on November 2002

Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress

scientific article published on 30 July 2018

Measurement of in vivo oxidative stress regulated by the Rac1 GTPase.

scientific article published in January 2004

MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.

scientific article published on 31 October 2013

MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1.

scientific article published on 24 August 2017

Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium.

scientific article published on 14 January 2017

NADPH oxidase activation increases the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate in human endothelial cells

scientific article published on 01 May 2000

Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling.

scientific article

Oxidant signalling in carcinogenesis: a commentary

scientific article published on 01 February 2002

P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia

scientific article published on 15 May 2014

P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.

scientific article published on 27 October 2016

P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction

scientific journal article

Priming of platelet alphaIIbbeta3 by oxidants is associated with tyrosine phosphorylation of beta3

scientific article published on 01 November 1998

Protection from reoxygenation injury by inhibition of rac1.

scientific article published on May 1998

Rac1 is required for cell proliferation and G2/M progression.

scientific article published on August 1997

Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells.

scientific article published in August 2004

Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells

scientific article published on 01 August 1994

Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.

scientific article

Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase

scientific article published on 23 April 2002

Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells.

scientific article published on 03 October 2001

Reduced left ventricular dimension and normalized atrial natriuretic hormone level after repair of aortic coarctation in an adult

scientific article published on 01 March 1999

Reduced wall compliance suppresses Akt-dependent apoptosis protection stimulated by pulse perfusion.

scientific article published on 11 August 2005

Regulation of endothelial cell adhesion by profilin

scientific article published on 01 January 1997

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

scientific article published on September 1996

Reversible lysine acetylation: Another layer of post-translational regulation of the cardiac sodium channel.

scientific article

Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling.

scientific article published on 27 July 2005

SIRT1 deacetylates APE1 and regulates cellular base excision repair

scientific article

SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

scholarly article

Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS

scientific article published on 01 April 1999

Signal transducer and activator of transcription 3alpha and specificity protein 1 interact to upregulate intercellular adhesion molecule-1 in ischemic-reperfused myocardium and vascular endothelium.

scientific article

Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.

scientific article published on 13 February 2017

Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.

scientific article published on 9 February 2017

Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction

scientific article published on 30 January 2017

Sos-mediated activation of rac1 by p66shc

scientific article

Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD

scientific article published on 01 December 2004

Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms ⬇️

scientific article published on October 1, 2003

The actin cytoskeleton reorganization induced by Rac1 requires the production of superoxide

scientific article published on 01 January 1999

Tie-ing the antiinflammatory effect of angiopoietin-1 to inhibition of NF-kappaB

scientific article published on 01 April 2003

Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.

scientific article

Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis

scientific article published on 02 September 2004

Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1.

scientific article published on 02 September 2016

[Ca(2+)](i) oscillation frequency regulates agonist-stimulated NF-kappaB transcriptional activity

scientific article published on 01 November 1999

p53 Impairs Endothelial Function by Transcriptionally Repressing Kruppel-Like Factor 2 ⬇️

scientific article published on October 14, 2010

p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.

scientific article

p66(Shc) has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism.

scientific article published on 21 June 2010

von Willebrand factor interacts with malignant hematopoietic cell lines: evidence for the presence of specific binding sites and modification of von Willebrand factor structure and function

scientific article published on 01 May 1992

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