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List of works by Luis J. Santín

1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats.

scientific article published on 7 January 2014

5-HT1A receptor activation before acute stress counteracted the induced long-term behavioral effects.

scientific article published in June 2004

5-HT1A receptor activation counteracted the effect of acute immobilization of noradrenergic neurons in the rat locus coeruleus

scientific article published on 2 January 2007

5-HT1A receptor activation counteracts c-Fos immunoreactivity induced in serotonin neurons of the raphe nuclei after immobilization stress in the male rat.

scientific article published on 9 January 2006

A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats.

scientific article

A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis

scientific article

A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats

scientific article

Absence of LPA1 signaling results in defective cortical development.

scientific article published on 26 July 2007

Age-related changes of the nucleolar organizer regions without neuron loss in medial mamillary bodies (hypothalamus) in old rats

scientific article

Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA₁ receptor knockout mice

scientific article

Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats

scientific article published on 12 September 2018

Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain.

scientific article published on 27 April 2015

Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors

scientific article published on 2 September 2011

Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits

scientific article

Behaviour laterality in male rats: influence of practice and stress

scientific article published in July 1996

Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption.

scientific article published on 14 December 2015

Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats.

scientific article published on 6 December 2017

Changes in the Nucleolar Organizer Regions in the Tuberomammillar Region after Dehydration ⬇️

scientific article published on October 1, 1997

Chronic immobilization in the malpar1 knockout mice increases oxidative stress in the hippocampus.

scientific article

Cocaine-conditioned place preference is predicted by previous anxiety-like behavior and is related to an increased number of neurons in the basolateral amygdala

scientific article

Correction: Aggravation of Chronic Stress Effects on Hippocampal Neurogenesis and Spatial Memory in LPA1 Receptor Knockout Mice.

scientific article published on 29 November 2011

Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus

scientific article published on 29 July 2008

Dopamine D4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

scientific article published on 22 May 2016

Effects of ageing on allocentric and egocentric spatial strategies in the Wistar rat.

scientific article published in March 2001

Effects of chronic alcohol consumption on spatial reference and working memory tasks

scientific article published in February 2000

Effects of genetic deletion versus pharmacological blockade of the LPA receptor on depression-like behaviour and related brain functional activity

scientific article published on 10 September 2018

Effects of histamine precursor and (R)-α-methylhistamine on the avoidance response in rats ⬇️

scientific article published on October 15, 2001

Effects of mammillary body lesions on spatial reference and working memory tasks

scientific article

Effects of medial prefrontal cortex lesions on anxiety-like behaviour in restrained and non-restrained rats

scientific article published on 17 March 2009

Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons.

scientific article published on 25 May 2016

Ethanol- and diazepam-induced cytochrome oxidase activity in mammillary bodies

scientific article published in October 1996

Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor

scientific article published on 11 April 2010

Fear extinction and acute stress reactivity reveal a role of LPA(1) receptor in regulating emotional-like behaviors.

scientific article published on 18 June 2013

Functional networks involved in spatial learning strategies in middle-aged rats

scientific article published on 3 March 2012

Functional sex differences in the accessory olfactory bulb of the rat

scientific article published on 01 September 2000

Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression.

scientific article

Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system

scientific article published on 20 January 2016

Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats

scientific article published on 22 May 2019

Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions.

scientific article

Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects.

scientific article published on 14 December 2015

Galanin receptor/Neuropeptide Y receptor interactions in the dorsal raphe nucleus of the rat

scientific article published on 17 March 2011

Higher Impulsivity As a Distinctive Trait of Severe Cocaine Addiction among Individuals Treated for Cocaine or Alcohol Use Disorders

scientific article published on 13 February 2018

Highlighting the Role of Cognitive and Brain Reserve in the Substance use Disorder Field

scientific article published on 01 January 2019

Hippocampal c-Fos activation in normal and LPA₁-null mice after two object recognition tasks with different memory demands.

scientific article published on 17 April 2012

Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice

scientific article published on 30 May 2012

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

scientific article

Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer's Disease in a Preclinical Model: A Therapeutic Opportunity

scientific article published on 05 November 2020

Improvement of spatial memory by (R)-alpha-methylhistamine, a histamine H(3)-receptor agonist, on the Morris water-maze in rat.

scientific article published in February 2002

Involvement of IGF-II receptors in the antioxidant and neuroprotective effects of IGF-II on adult cortical neuronal cultures.

scientific article published on 22 March 2014

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

scientific article published on 30 January 2017

Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.

scientific article published on 17 September 2014

Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory.

scientific article published on 26 February 2018

Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats

scientific article published on 2 May 2013

Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation

scientific article published on 24 November 2018

Neuroplasticity and Healthy Lifestyle: How Can We Understand This Relationship?

scientific article published on 16 October 2017

Non-effects of mammillary body lesions on spontaneous alternation: pre and postoperative study

scientific article published in March 1999

Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice

scientific article published on 11 January 2018

Pharmacological reduction of adult hippocampal neurogenesis modifies functional brain circuits in mice exposed to a cocaine conditioned place preference paradigm

scientific article

Plasma concentrations of BDNF and IGF-1 in abstinent cocaine users with high prevalence of substance use disorders: relationship to psychiatric comorbidity

scientific article

Plasma redox status is impaired in the portacaval shunted rat--the risk of the reduced antioxidant ability.

scientific article

Portacaval shunt control animals: physiological consequences derived from the sham operation

scientific article published on 01 July 1997

Portal hypertension in 18-month-old rats: memory deficits and brain metabolic activity

scientific article

Reduced wheel running and blunted effects of voluntary exercise in LPA1-null mice: the importance of assessing the amount of running in transgenic mice studies

scientific article

Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition

scientific article published on 23 February 2020

Reversible changes in hippocampal CA1 synapses associated with water maze training in rats

scientific article published in March 2006

Role of Lysophosphatidic Acid (LPA) in Behavioral Processes: Implications for Psychiatric Disorders

scientific article published on 19 February 2013

Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system

scientific article published on 13 May 2019

Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients

scientific article published on 14 November 2019

Spatial learning and the hippocampus

scientific article published in September 2000

Supramammillary and adjacent nuclei lesions impair spatial working memory and induce anxiolitic-like behavior

scientific article published on 19 October 2005

Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior.

scientific article published on 26 January 2018

Temporary inactivation of the supramammillary area impairs spatial working memory and spatial reference memory retrieval

scientific article published on 9 February 2008

The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder

scientific article published on 05 May 2017

The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours

scientific article published on 31 January 2017

The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm

scientific article published on 23 September 2019

Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis

scientific article published on 31 March 2018

Unbiased estimation of the total number of nervous cells and volume of medial mammillary nucleus in humans

scientific article published in September 1999

Voluntary exercise followed by chronic stress strikingly increases mature adult-born hippocampal neurons and prevents stress-induced deficits in 'what-when-where' memory

scientific article published on 11 December 2013

When is adult hippocampal neurogenesis necessary for learning? evidence from animal research.

scientific article published on 13 May 2011

Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test

scientific article published on 09 March 2019

c-Fos expression in supramammillary and medial mammillary nuclei following spatial reference and working memory tasks

scientific article

maLPA1-null mice as an endophenotype of anxious depression

scientific article

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