List of works - Salvatore De Cosmo

A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria

scientific article published on 01 March 2000

A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities

scientific article published on 9 March 2007

A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome.

scientific article published in January 2008

A rare cause of shortness of breath: relaxatio diaphragmatica

scientific article published on 28 May 2015

A reliable and reproducible test for adequate glucose counterregulation in type I diabetes mellitus.

scientific article

Achievement of therapeutic targets in patients with diabetes and chronic kidney disease: insights from the Associazione Medici Diabetologi Annals initiative

scientific article

Akt2 Gene common allelic variants in insulin resistance and the metabolic syndrome

scientific article published on 18 June 2007

Alcoholic cardiomyopathy: What is known and what is not known.

scientific article

Algorithms for personalized therapy of type 2 diabetes: results of a web-based international survey

scientific article

An association study between epicardial fat thickness and cognitive impairment in the elderly

scientific article published in November 2014

Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly.

scientific article

Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and combined therapy in patients with micro- and macroalbuminuria and other cardiovascular risk factors: a systematic review of randomized controlled trials

scientific article

Antihyperglycemic treatment in patients with type 2 diabetes in Italy: the impact of age and kidney function

scientific article published on 28 June 2017

Apparent Treatment Resistant Hypertension, Blood Pressure Control and the Progression of Chronic Kidney Disease in Patients with Type 2 Diabetes

scientific article published on 16 March 2018

Association of kidney disease measures with risk of renal function worsening in patients with hypertension and type 2 diabetes.

scientific article published on 29 October 2016

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.

scientific article

BMI correlates with pulse pressure in offspring of patients with type 2 diabetes and albuminuria

scientific article published on 21 March 2018

Beta cell stress in a 4-year follow-up of patients with type 2 diabetes: A longitudinal analysis of the BetaDecline Study

scientific article published on 21 May 2018

Blood pressure status and the incidence of diabetic kidney disease in patients with hypertension and type 2 diabetes.

scientific article published on 21 July 2016

Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study

scientific article published on 01 August 2018

Chronic diarrhea in a patient with severe vitamin B12 deficiency: a rare clinical manifestation

scientific article published on 21 January 2016

Chronic inflammation in offspring of patients with type 2 diabetes and albuminuria.

scientific article published on 8 April 2015

Cigarette smoking is associated with low glomerular filtration rate in male patients with type 2 diabetes.

scientific article published in November 2006

Clinical approach to diabetic Cardiomiopathy: a review of human studies.

scientific article

Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation

scientific article published in January 2016

Demonstration of a dawn phenomenon in normal human volunteers

scientific article published on 01 December 1984

Development and validation of a predicting model of all-cause mortality in patients with type 2 diabetes

scientific article published on May 2013

Diabetic kidney disease in the elderly: prevalence and clinical correlates

scientific article

Digital ulcers in scleroderma patients: A retrospective observational study

scientific article published on 18 December 2015

Does high-dose benzodiazepine abuse really produce liver toxicity? Results from a series of 201 benzodiazepine monoabusers

scientific article published on 6 April 2018

ENPP1 gene, insulin resistance and related clinical outcomes

scientific article

Early renal abnormalities as an indicator of cardiovascular risk in type 2 diabetes

scientific article published on August 2014

Economic aspects in the management of diabetes in Italy

scientific article published on 10 October 2016

Effects of long-term optimization and short-term deterioration of glycemic control on glucose counterregulation in type I diabetes mellitus

scientific article published on 01 April 1984

Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

scientific article published on 12 September 2017

Epidemiology of diabetic kidney disease in adult patients with type 1 diabetes in Italy: The AMD-Annals initiative

scientific article published on 9 December 2016

Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions

scientific article published on 19 September 2018

Gastrointestinal Motor Dysfunction, Symptoms, and Neuropathy in Noninsulin-Dependent (Type 2) Diabetes Mellitus

scientific article published on 01 September 1999

Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes

scientific article published on 12 February 2015

Glucose targets for preventing diabetic kidney disease and its progression

scientific article published on 8 June 2017

Glucose-induced changes in renal haemodynamics in proteinuric type 1 (insulin-dependent) diabetic patients: inhibition by acetylsalicilic acid infusion.

scientific article

Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes

scientific article published in October 2007

Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians.

scientific article published on 2 May 2006

High prevalence of risk factors for cardiovascular disease in parents of IDDM patients with albuminuria

scientific article published on 01 October 1997

IRS1 G972R missense polymorphism is associated with failure to oral antidiabetes drugs in white patients with type 2 diabetes from Italy.

scientific article published on 19 June 2014

Identification and Clinical Characterization of Adult Patients with Multigenerational Diabetes Mellitus

scientific article published on 19 August 2015

Identifying patients with type 2 diabetes at high risk of microalbuminuria: results of the DEMAND (Developing Education on Microalbuminuria for Awareness of reNal and cardiovascular risk in Diabetes) Study

scientific article published on 26 November 2007

Impact of the PPAR-gamma2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: evidence from BENEDICT

scientific article published on 31 August 2009

Incidence and correlated factors of beta cell failure in a 4-year follow-up of patients with type 2 diabetes: a longitudinal analysis of the BETADECLINE study.

scientific article published on 18 May 2016

Increased cardiovascular risk among type 2 diabetic patients with high-normal albuminuria and no evidence of kidney impairment

scientific article published on 26 September 2010

Insulin resistance and the cluster of abnormalities related to the metabolic syndrome are associated with reduced glomerular filtration rate in patients with type 2 diabetes

scientific article published on 01 February 2006

Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.

scientific article

Isolated pons involvement in Posterior Reversible Encephalopathy Syndrome: Case report and review of the literature

scientific article published on 28 November 2016

Joint effect of insulin signaling genes on all-cause mortality

scientific article

Kidney disease measures are associated with the burden of coronary atherosclerosis, independently of diabetes

scientific article published on 21 July 2017

Kidney dysfunction and related cardiovascular risk factors among patients with type 2 diabetes

scientific article

Lack of evidence for the 1484insG variant at the 3'-UTR of the protein tyrosine phosphatase 1B (PTP1B) gene as a genetic determinant of diabetic nephropathy development in type 1 diabetic patients.

scientific article

Management of type 2 diabetes in geriatric patients.

scientific article published on September 2010

Metabolic syndrome is not a risk factor for kidney dysfunction in obese non-diabetic subjects.

scientific article published on 31 January 2008

Metabolic syndrome, serum uric acid and renal risk in patients with T2D.

scientific article

Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging

scientific article

Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity.

scientific article published on 09 April 2014

Normoalbuminuric renal impairment and all-cause mortality in type 2 diabetes mellitus

scientific article published on 13 March 2014

Obesity and changes in urine albumin/creatinine ratio in patients with type 2 diabetes: the DEMAND study.

scientific article published on 17 May 2009

Occurrence over time and regression of nonalcoholic fatty liver disease in type 2 diabetes

scientific article published on 29 December 2016

On the non-linear association between serum uric acid levels and all-cause mortality rate in patients with type 2 diabetes mellitus

scientific article published on 9 March 2017

PC-1 Amino Acid Variant Q121 Is Associated With a Lower Glomerular Filtration Rate in Type 2 Diabetic Patients With Abnormal Albumin Excretion Rates

scientific article published on 26 September 2003

PPAR 2 P12A polymorphism and albuminuria in patients with type 2 diabetes: a meta-analysis of case-control studies

article

Patient/disease features and glycemic targets in type 2 diabetes: Where do we stand?

scientific article published on 11 January 2016

Plasma Triglycerides and HDL-C Levels Predict the Development of Diabetic Kidney Disease in Subjects With Type 2 Diabetes: The AMD Annals Initiative.

scientific article published on 4 October 2016

Podocyte number in normotensive type 1 diabetic patients with albuminuria

scientific article published in October 2002

Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative

scientific article

Predictors of chronic kidney disease in type 2 diabetes: A longitudinal study from the AMD Annals initiative

scientific article published on July 2016

Prevalence and correlates of erectile dysfunction in men on chronic haemodialysis: a multinational cross-sectional study

scientific article published on 29 December 2011

Relationship between ADIPOQ gene, circulating high molecular weight adiponectin and albuminuria in individuals with normal kidney function: evidence from a family-based study

scientific article published on 13 January 2011

Renal functional response to protein loading in type 1 (insulin-dependent) diabetic patients on normal or high salt intake

scientific article published on 01 January 1997

Resistant Hypertension, Time-Updated Blood Pressure Values and Renal Outcome in Type 2 Diabetes Mellitus.

scientific article published on 22 September 2017

Retinoid X Receptors Intersect the Molecular Clockwork in the Regulation of Liver Metabolism

scientific article published on 13 February 2017

Role of PC-1 and ACE genes on insulin resistance and cardiac mass in never-treated hypertensive patients. Suggestive evidence for a digenic additive modulation

article

Role of insulin resistance in kidney dysfunction: insights into the mechanism and epidemiological evidence.

scientific article published on 09 October 2012

Role of obesity on all-cause mortality in whites with type 2 diabetes from Italy

article

Role of relationship between HbA1c, fibrinogen and HDL-cholesterol on cardiovascular disease in patients with type 2 diabetes mellitus

scientific article published on 20 February 2013

Screening for silent myocardial ischaemia in type 2 diabetic patients with additional atherogenic risk factors: applicability and accuracy of the exercise stress test

scientific article published on 01 November 2002

Sepsis in Internal Medicine wards: current knowledge, uncertainties and new approaches for management optimization.

scientific article published on 18 May 2017

Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes

scientific article published on 14 October 2015

Serum Resistin, Cardiovascular Disease and All-Cause Mortality in Patients with Type 2 Diabetes ⬇️

scientific article published on June 3, 2013

Serum Uric Acid and Risk of CKD in Type 2 Diabetes

scientific article

Serum resistin and glomerular filtration rate in patients with type 2 diabetes

scientific article

Serum resistin and kidney function: a family-based study in non-diabetic, untreated individuals

scientific article (publication date: 2012)

Serum resistin is causally related to mortality risk in patients with type 2 diabetes: preliminary evidences from genetic data

scientific article

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis ⬇️

scientific article published on April 5, 2012

Target values of cardiovascular risk factors are not associated with all-cause mortality in patients with type 2 diabetes mellitus

scientific article published on 30 April 2015

The "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes": Study protocol

scientific article published on 9 October 2015

The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus.

scientific article published on 23 May 2012

The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis

scientific article

The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

scientific article published on 30 March 2016

The Decorin gene 179 allelic variant is associated with a slower progression of renal disease in patients with type 1 diabetes

scientific article published on 01 September 2002

The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients

scientific article

The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.

scientific article published on 26 September 2013

The Long-Term Impact of Renin-Angiotensin System (RAS) Inhibition on Cardiorenal Outcomes (LIRICO): A Randomized, Controlled Trial

scientific article published on 12 November 2018

The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus

scientific article published on 8 March 2016

The Synergic Association of hs-CRP and Serum Amyloid P Component in Predicting All-Cause Mortality in Patients With Type 2 Diabetes

scientific article published on 06 March 2020

The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy

scientific article

The paradoxical association of adiponectin with mortality rate in patients with type 2 diabetes: evidence of synergism with kidney function

scientific article published on 22 December 2015

The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression

scientific article (publication date: August 2002)

The rs12917707 polymorphism at theUMODlocus and glomerular filtration rate in individuals with type 2 diabetes: evidence of heterogeneity across two different European populations

scientific article published on 01 October 2017

Trend over time in hepatic fibrosis score in a cohort of type 2 diabetes patients

scientific article

Urinary albumin excretion correlates with carotid intima-media thickness in offspring of patients with type 2 diabetes and albuminuria

scientific article published on 11 April 2016

Urine proteome analysis may allow noninvasive differential diagnosis of diabetic nephropathy ⬇️

scientific article

Variability in HbA1c, blood pressure, lipid parameters and serum uric acid, and risk of development of chronic kidney disease in type 2 diabetes

scientific article published on 21 April 2017

Zolpidem high-dose abuse: what about the liver? Results from a series of 107 patients

scientific article published on 14 June 2019

List of works by Salvatore De Cosmo

A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria

A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities

A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome.

A rare cause of shortness of breath: relaxatio diaphragmatica

A reliable and reproducible test for adequate glucose counterregulation in type I diabetes mellitus.

Achievement of therapeutic targets in patients with diabetes and chronic kidney disease: insights from the Associazione Medici Diabetologi Annals initiative

Akt2 Gene common allelic variants in insulin resistance and the metabolic syndrome

Alcoholic cardiomyopathy: What is known and what is not known.

Algorithms for personalized therapy of type 2 diabetes: results of a web-based international survey

An association study between epicardial fat thickness and cognitive impairment in the elderly

Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly.

Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and combined therapy in patients with micro- and macroalbuminuria and other cardiovascular risk factors: a systematic review of randomized controlled trials

Antihyperglycemic treatment in patients with type 2 diabetes in Italy: the impact of age and kidney function

Apparent Treatment Resistant Hypertension, Blood Pressure Control and the Progression of Chronic Kidney Disease in Patients with Type 2 Diabetes

Association of kidney disease measures with risk of renal function worsening in patients with hypertension and type 2 diabetes.

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.

BMI correlates with pulse pressure in offspring of patients with type 2 diabetes and albuminuria

Beta cell stress in a 4-year follow-up of patients with type 2 diabetes: A longitudinal analysis of the BetaDecline Study

Blood pressure status and the incidence of diabetic kidney disease in patients with hypertension and type 2 diabetes.

Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study

Chronic diarrhea in a patient with severe vitamin B12 deficiency: a rare clinical manifestation

Chronic inflammation in offspring of patients with type 2 diabetes and albuminuria.

Cigarette smoking is associated with low glomerular filtration rate in male patients with type 2 diabetes.

Clinical approach to diabetic Cardiomiopathy: a review of human studies.

Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation

Demonstration of a dawn phenomenon in normal human volunteers

Development and validation of a predicting model of all-cause mortality in patients with type 2 diabetes

Diabetic kidney disease in the elderly: prevalence and clinical correlates

Digital ulcers in scleroderma patients: A retrospective observational study

Does high-dose benzodiazepine abuse really produce liver toxicity? Results from a series of 201 benzodiazepine monoabusers

ENPP1 gene, insulin resistance and related clinical outcomes

Early renal abnormalities as an indicator of cardiovascular risk in type 2 diabetes

Economic aspects in the management of diabetes in Italy

Effects of long-term optimization and short-term deterioration of glycemic control on glucose counterregulation in type I diabetes mellitus

Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Epidemiology of diabetic kidney disease in adult patients with type 1 diabetes in Italy: The AMD-Annals initiative

Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions

Gastrointestinal Motor Dysfunction, Symptoms, and Neuropathy in Noninsulin-Dependent (Type 2) Diabetes Mellitus

Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes

Glucose targets for preventing diabetic kidney disease and its progression

Glucose-induced changes in renal haemodynamics in proteinuric type 1 (insulin-dependent) diabetic patients: inhibition by acetylsalicilic acid infusion.

Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes

Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians.

High prevalence of risk factors for cardiovascular disease in parents of IDDM patients with albuminuria

IRS1 G972R missense polymorphism is associated with failure to oral antidiabetes drugs in white patients with type 2 diabetes from Italy.

Identification and Clinical Characterization of Adult Patients with Multigenerational Diabetes Mellitus

Identifying patients with type 2 diabetes at high risk of microalbuminuria: results of the DEMAND (Developing Education on Microalbuminuria for Awareness of reNal and cardiovascular risk in Diabetes) Study

Impact of the PPAR-gamma2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: evidence from BENEDICT

Incidence and correlated factors of beta cell failure in a 4-year follow-up of patients with type 2 diabetes: a longitudinal analysis of the BETADECLINE study.

Increased cardiovascular risk among type 2 diabetic patients with high-normal albuminuria and no evidence of kidney impairment

Insulin resistance and the cluster of abnormalities related to the metabolic syndrome are associated with reduced glomerular filtration rate in patients with type 2 diabetes

Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.

Isolated pons involvement in Posterior Reversible Encephalopathy Syndrome: Case report and review of the literature

Joint effect of insulin signaling genes on all-cause mortality

Kidney disease measures are associated with the burden of coronary atherosclerosis, independently of diabetes

Kidney dysfunction and related cardiovascular risk factors among patients with type 2 diabetes

Lack of evidence for the 1484insG variant at the 3'-UTR of the protein tyrosine phosphatase 1B (PTP1B) gene as a genetic determinant of diabetic nephropathy development in type 1 diabetic patients.

Management of type 2 diabetes in geriatric patients.

Metabolic syndrome is not a risk factor for kidney dysfunction in obese non-diabetic subjects.

Metabolic syndrome, serum uric acid and renal risk in patients with T2D.

Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging

Non-alcoholic fatty liver disease: the role of nuclear receptors and circadian rhythmicity.

Normoalbuminuric renal impairment and all-cause mortality in type 2 diabetes mellitus

Obesity and changes in urine albumin/creatinine ratio in patients with type 2 diabetes: the DEMAND study.

Occurrence over time and regression of nonalcoholic fatty liver disease in type 2 diabetes

On the non-linear association between serum uric acid levels and all-cause mortality rate in patients with type 2 diabetes mellitus

PC-1 Amino Acid Variant Q121 Is Associated With a Lower Glomerular Filtration Rate in Type 2 Diabetic Patients With Abnormal Albumin Excretion Rates

PPAR 2 P12A polymorphism and albuminuria in patients with type 2 diabetes: a meta-analysis of case-control studies

Patient/disease features and glycemic targets in type 2 diabetes: Where do we stand?

Plasma Triglycerides and HDL-C Levels Predict the Development of Diabetic Kidney Disease in Subjects With Type 2 Diabetes: The AMD Annals Initiative.

Podocyte number in normotensive type 1 diabetic patients with albuminuria

Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative

Predictors of chronic kidney disease in type 2 diabetes: A longitudinal study from the AMD Annals initiative

Prevalence and correlates of erectile dysfunction in men on chronic haemodialysis: a multinational cross-sectional study

Relationship between ADIPOQ gene, circulating high molecular weight adiponectin and albuminuria in individuals with normal kidney function: evidence from a family-based study

Renal functional response to protein loading in type 1 (insulin-dependent) diabetic patients on normal or high salt intake

Resistant Hypertension, Time-Updated Blood Pressure Values and Renal Outcome in Type 2 Diabetes Mellitus.

Retinoid X Receptors Intersect the Molecular Clockwork in the Regulation of Liver Metabolism

Role of PC-1 and ACE genes on insulin resistance and cardiac mass in never-treated hypertensive patients. Suggestive evidence for a digenic additive modulation