List of works - Christophe Léger

"Two-step" chronoamperometric method for studying the anaerobic inactivation of an oxygen tolerant NiFe hydrogenase

scientific article published in April 2010

A distal histidine mutant (H52Q) of yeast cytochrome c peroxidase catalyzes the oxidation of H(2)O(2) instead of its reduction

scientific article published in September 2001

A needle in a haystack: The active site of the membrane-bound complex cytochromecnitrite reductase

scientific article published on 19 December 2006

A threonine stabilizes the NiC and NiR catalytic intermediates of [NiFe]-hydrogenase.

scientific article

Access to the Active Site of Periplasmic Nitrate Reductase: Insights from Site-Directed Mutagenesis and Zinc Inhibition Studies†

scientific article published on 03 August 2007

Architecture of succinate dehydrogenase and reactive oxygen species generation

scientific article (publication date: 31 January 2003)

Arginine171 of Chlamydomonas reinhardtii [Fe–Fe] hydrogenase HydA1 plays a crucial role in electron transfer to its catalytic center

article published in 2013

Biochemical and biophysical characterization of succinate: quinone reductase from Thermus thermophilus

scientific article published on 14 October 2010

CO Disrupts the Reduced H-Cluster of FeFe Hydrogenase. A Combined DFT and Protein Film Voltammetry Study

scientific article published on 27 January 2011

CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2.

scientific article published on 11 October 2017

Changing the Ligation of the Distal [4Fe4S] Cluster in NiFe Hydrogenase Impairs Inter- and Intramolecular Electron Transfers

scientific article published on 01 April 2006

Characterization of two 2[4Fe4S] ferredoxins from Clostridium acetobutylicum

scientific article published on 12 December 2007

Combining experimental and theoretical methods to learn about the reactivity of gas-processing metalloenzymes

Complete Protection of O2-Sensitive Catalysts in Thin Films

scientific article published on 10 October 2019

Correcting for Electrocatalyst Desorption and Inactivation in Chronoamperometry Experiments

scientific article published on 01 April 2009

Correction to "Mechanism of Protection of Catalysts Supported in Redox Hydrogel Films"

scientific article published on 15 November 2019

Covalent Attachment of FeFe Hydrogenases to Carbon Electrodes for Direct Electron Transfer

scientific article published on 30 August 2012

Dense Branching Morphology in Electrodeposition Experiments: Characterization and Mean-Field Modeling

scientific article published in Physical Review Letters

Dependence of catalytic activity on driving force in solution assays and protein film voltammetry: insights from the comparison of nitrate reductase mutants

scientific article published in March 2010

Detection and interpretation of redox potential optima in the catalytic activity of enzymes

scientific article

Dinitrogen Reduction: Interfacing the Enzyme Nitrogenase with Electrodes

scientific article

Direct electrochemistry of redox enzymes as a tool for mechanistic studies

scientific article published on July 2008

Does the environment around the H-cluster allow coordination of the pendant amine to the catalytic iron center in [FeFe] hydrogenases? Answers from theory

scientific article

Dynamical characterization of one-dimensional stationary growth regimes in diffusion-limited electrodeposition processes

article by Christophe Léger et al published 1 December 1998 in Physical Review E

Effect of a Dispersion of Interfacial Electron Transfer Rates on Steady State Catalytic Electron Transport in [NiFe]-hydrogenase and Other Enzymes

Effects of slow substrate binding and release in redox enzymes: theory and application to periplasmic nitrate reductase.

scientific article published on 4 August 2007

Electrochemical Investigations of Hydrogenases and Other Enzymes That Produce and Use Solar Fuels.

scientific article

Electrochemical Measurements of the Kinetics of Inhibition of Two FeFe Hydrogenases by O2 Demonstrate That the Reaction Is Partly Reversible.

scientific article

Electron flow in multicenter enzymes: theory, applications, and consequences on the natural design of redox chains

scientific article published in January 2006

Engineering an [FeFe]-hydrogenase: do accessory clusters influence O2 resistance and catalytic bias?

scientific article published on 29 March 2018

Enzyme Electrokinetics: Hydrogen Evolution and Oxidation byAllochromatium vinosum[NiFe]-Hydrogenase†

scientific article published on 01 December 2002

Enzyme electrokinetics: using protein film voltammetry to investigate redox enzymes and their mechanisms

scientific article

Experimental Demonstration of Diffusion-Limited Dynamics in Electrodeposition

scientific article published in Physical Review Letters

Experimental approaches to kinetics of gas diffusion in hydrogenase

scientific article

Fast voltammetric studies of the kinetics and energetics of coupled electron-transfer reactions in proteins.

scientific article published in January 2000

FeFe hydrogenase reductive inactivation and implication for catalysis

Front Dynamics during Diffusion-Limited Corrosion of Ramified Electrodeposits

article

Growth patterns in electrodeposition

Hydrogen-Activating Enzymes: Activity Does Not Correlate with Oxygen Sensitivity

Hydrogen-activating enzymes: activity does not correlate with oxygen sensitivity

scientific article published in January 2008

In Rhodobacter sphaeroides respiratory nitrate reductase, the kinetics of substrate binding favors intramolecular electron transfer

scientific article published in February 2004

Inhibition and Aerobic Inactivation Kinetics ofDesulfovibrio fructosovoransNiFe Hydrogenase Studied by Protein Film Voltammetry

scientific article published on 01 September 2004

Interaction of the H-Cluster of FeFe Hydrogenase with Halides.

scientific article published on 28 March 2018

Interdomain contacts in flavocytochrome b(2), a mutational analysis

scientific article published in November 2009

Interferometric characterization of growth dynamics during dendritic electrodeposition of zinc

scientific article published on 01 February 1996

Internal structure of dense electrodeposits

scientific article published on 01 May 2000

Introduction of methionines in the gas channel makes [NiFe] hydrogenase aero-tolerant

scientific article

Is engineering O2-tolerant hydrogenases just a matter of reproducing the active sites of the naturally occurring O2-resistant enzymes?

Kinetics of substrate inhibition of periplasmic nitrate reductase

scientific article published on 02 June 2014

Major Mo(V) EPR signature of Rhodobacter sphaeroides periplasmic nitrate reductase arising from a dead-end species that activates upon reduction. Relation to other molybdoenzymes from the DMSO reductase family

scientific article

Maturation of the [Ni-4Fe-4S] active site of carbon monoxide dehydrogenases

scientific article published on 14 February 2018

Mechanism of O2 diffusion and reduction in FeFe hydrogenases

scientific article

Mechanism of inhibition of NiFe hydrogenase by nitric oxide.

scientific article published on 29 January 2016

Mechanism of protection of catalysts supported in redox hydrogel films

scientific article

Membrane-Bound Hydrogenase I from the Hyperthermophilic BacteriumAquifex aeolicus: Enzyme Activation, Redox Intermediates and Oxygen Tolerance

scientific article published on 01 May 2010

Modelling the voltammetry of adsorbed enzymes and molecular catalysts

N2 -Reduktion: Verschaltung von Nitrogenase mit Elektroden

New perspectives in hydrogenase direct electrochemistry

article by Matteo Sensi et al published October 2017 in Current Opinion in Electrochemistry

O2 Inhibition of Ni-Containing CO Dehydrogenase Is Partly Reversible

scientific article published on 16 November 2015

O2-independent formation of the inactive states of NiFe hydrogenase

scientific article published on 11 November 2012

Original Design of an Oxygen-Tolerant [NiFe] Hydrogenase: Major Effect of a Valine-to-Cysteine Mutation near the Active Site

scientific article published on 22 December 2010

Oxidative inactivation of NiFeSe hydrogenase

scientific article published on 11 August 2015

Photoinhibition of FeFe Hydrogenase

Probing interfacial dynamics by phase-shift interferometry in thin cell electrodeposition

article

Protein Electrochemistry: Questions and Answers.

scientific article published on 16 September 2016

Rates of Intra- and Intermolecular Electron Transfers in Hydrogenase Deduced from Steady-State Activity Measurements

scientific article published on 14 June 2011

Reactivity of the excited states of the H-cluster of FeFe hydrogenases.

scientific article published on 20 September 2016

Reassessing the Strategies for Trapping Catalytic Intermediates during Nitrate Reductase Turnover

scientific article published on 01 March 2010

Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase

scientific article published on 02 October 2018

Reductive activation in periplasmic nitrate reductase involves chemical modifications of the Mo-cofactor beyond the first coordination sphere of the metal ion.

scientific article published on 7 November 2013

Reductive activation of E. coli respiratory nitrate reductase

scientific article

Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase.

scientific article

Relation between anaerobic inactivation and oxygen tolerance in a large series of NiFe hydrogenase mutants

scientific article

Roles of the F-domain in [FeFe] hydrogenase

scientific article published on 24 August 2017

SOAS: a free program to analyze electrochemical data and other one-dimensional signals

scientific article

Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase

scientific article published in 2022

Steady-State Catalytic Wave-Shapes for 2-Electron Reversible Electrocatalysts and Enzymes

scientific article published on 01 March 2013

Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase

scientific article published on 11 July 2019

The Carbon Monoxide Dehydrogenase from Desulfovibrio vulgaris.

scientific article published on 6 August 2015

The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance in Desulfovibrio vulgaris Ni-Fe Carbon Monoxide Dehydrogenase

scientific article published on 04 June 2020

The mechanism of inhibition by H2 of H2-evolution by hydrogenases.

scientific article published on 24 June 2013

The oxidative inactivation of FeFe hydrogenase reveals the flexibility of the H-cluster

scientific article published on 16 March 2014

The quest for a functional substrate access tunnel in FeFe hydrogenase.

scientific article published on January 2011

Towards engineering O2-tolerance in [Ni–Fe] hydrogenases

Understanding and Design of Bidirectional and Reversible Catalysts of Multielectron, Multistep Reactions

scientific article published on 08 July 2019

Understanding and Tuning the Catalytic Bias of Hydrogenase

article

Understanding and tuning the catalytic bias of hydrogenase.

scientific article

Valine-to-Cysteine Mutation Further Increases the Oxygen Tolerance of <i>Escherichia coli</i> NiFe Hydrogenase Hyd-1

scientific article published in 2019

List of works by Christophe Léger

"Two-step" chronoamperometric method for studying the anaerobic inactivation of an oxygen tolerant NiFe hydrogenase

A distal histidine mutant (H52Q) of yeast cytochrome c peroxidase catalyzes the oxidation of H(2)O(2) instead of its reduction

A needle in a haystack: The active site of the membrane-bound complex cytochromecnitrite reductase

A threonine stabilizes the NiC and NiR catalytic intermediates of [NiFe]-hydrogenase.

Access to the Active Site of Periplasmic Nitrate Reductase: Insights from Site-Directed Mutagenesis and Zinc Inhibition Studies†

Architecture of succinate dehydrogenase and reactive oxygen species generation

Arginine171 of Chlamydomonas reinhardtii [Fe–Fe] hydrogenase HydA1 plays a crucial role in electron transfer to its catalytic center

Biochemical and biophysical characterization of succinate: quinone reductase from Thermus thermophilus

CO Disrupts the Reduced H-Cluster of FeFe Hydrogenase. A Combined DFT and Protein Film Voltammetry Study

CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2.

Changing the Ligation of the Distal [4Fe4S] Cluster in NiFe Hydrogenase Impairs Inter- and Intramolecular Electron Transfers

Characterization of two 2[4Fe4S] ferredoxins from Clostridium acetobutylicum

Combining experimental and theoretical methods to learn about the reactivity of gas-processing metalloenzymes

Complete Protection of O2-Sensitive Catalysts in Thin Films

Correcting for Electrocatalyst Desorption and Inactivation in Chronoamperometry Experiments

Correction to "Mechanism of Protection of Catalysts Supported in Redox Hydrogel Films"

Covalent Attachment of FeFe Hydrogenases to Carbon Electrodes for Direct Electron Transfer

Dense Branching Morphology in Electrodeposition Experiments: Characterization and Mean-Field Modeling

Dependence of catalytic activity on driving force in solution assays and protein film voltammetry: insights from the comparison of nitrate reductase mutants

Detection and interpretation of redox potential optima in the catalytic activity of enzymes

Dinitrogen Reduction: Interfacing the Enzyme Nitrogenase with Electrodes

Direct electrochemistry of redox enzymes as a tool for mechanistic studies

Does the environment around the H-cluster allow coordination of the pendant amine to the catalytic iron center in [FeFe] hydrogenases? Answers from theory

Dynamical characterization of one-dimensional stationary growth regimes in diffusion-limited electrodeposition processes

Effect of a Dispersion of Interfacial Electron Transfer Rates on Steady State Catalytic Electron Transport in [NiFe]-hydrogenase and Other Enzymes

Effects of slow substrate binding and release in redox enzymes: theory and application to periplasmic nitrate reductase.

Electrochemical Investigations of Hydrogenases and Other Enzymes That Produce and Use Solar Fuels.

Electrochemical Measurements of the Kinetics of Inhibition of Two FeFe Hydrogenases by O2 Demonstrate That the Reaction Is Partly Reversible.

Electron flow in multicenter enzymes: theory, applications, and consequences on the natural design of redox chains

Engineering an [FeFe]-hydrogenase: do accessory clusters influence O2 resistance and catalytic bias?

Enzyme Electrokinetics: Hydrogen Evolution and Oxidation byAllochromatium vinosum[NiFe]-Hydrogenase†

Enzyme electrokinetics: using protein film voltammetry to investigate redox enzymes and their mechanisms

Experimental Demonstration of Diffusion-Limited Dynamics in Electrodeposition

Experimental approaches to kinetics of gas diffusion in hydrogenase

Fast voltammetric studies of the kinetics and energetics of coupled electron-transfer reactions in proteins.

FeFe hydrogenase reductive inactivation and implication for catalysis

Front Dynamics during Diffusion-Limited Corrosion of Ramified Electrodeposits

Growth patterns in electrodeposition

Hydrogen-Activating Enzymes: Activity Does Not Correlate with Oxygen Sensitivity

Hydrogen-activating enzymes: activity does not correlate with oxygen sensitivity

In Rhodobacter sphaeroides respiratory nitrate reductase, the kinetics of substrate binding favors intramolecular electron transfer

Inhibition and Aerobic Inactivation Kinetics ofDesulfovibrio fructosovoransNiFe Hydrogenase Studied by Protein Film Voltammetry

Interaction of the H-Cluster of FeFe Hydrogenase with Halides.

Interdomain contacts in flavocytochrome b(2), a mutational analysis

Interferometric characterization of growth dynamics during dendritic electrodeposition of zinc

Internal structure of dense electrodeposits

Introduction of methionines in the gas channel makes [NiFe] hydrogenase aero-tolerant

Is engineering O2-tolerant hydrogenases just a matter of reproducing the active sites of the naturally occurring O2-resistant enzymes?

Kinetics of substrate inhibition of periplasmic nitrate reductase

Major Mo(V) EPR signature of Rhodobacter sphaeroides periplasmic nitrate reductase arising from a dead-end species that activates upon reduction. Relation to other molybdoenzymes from the DMSO reductase family

Maturation of the [Ni-4Fe-4S] active site of carbon monoxide dehydrogenases

Mechanism of O2 diffusion and reduction in FeFe hydrogenases

Mechanism of inhibition of NiFe hydrogenase by nitric oxide.

Mechanism of protection of catalysts supported in redox hydrogel films

Membrane-Bound Hydrogenase I from the Hyperthermophilic BacteriumAquifex aeolicus: Enzyme Activation, Redox Intermediates and Oxygen Tolerance

Modelling the voltammetry of adsorbed enzymes and molecular catalysts

N2 -Reduktion: Verschaltung von Nitrogenase mit Elektroden

New perspectives in hydrogenase direct electrochemistry

O2 Inhibition of Ni-Containing CO Dehydrogenase Is Partly Reversible

O2-independent formation of the inactive states of NiFe hydrogenase

Original Design of an Oxygen-Tolerant [NiFe] Hydrogenase: Major Effect of a Valine-to-Cysteine Mutation near the Active Site

Oxidative inactivation of NiFeSe hydrogenase

Photoinhibition of FeFe Hydrogenase

Probing interfacial dynamics by phase-shift interferometry in thin cell electrodeposition

Protein Electrochemistry: Questions and Answers.

Rates of Intra- and Intermolecular Electron Transfers in Hydrogenase Deduced from Steady-State Activity Measurements

Reactivity of the excited states of the H-cluster of FeFe hydrogenases.

Reassessing the Strategies for Trapping Catalytic Intermediates during Nitrate Reductase Turnover

Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase

Reductive activation in periplasmic nitrate reductase involves chemical modifications of the Mo-cofactor beyond the first coordination sphere of the metal ion.

Reductive activation of E. coli respiratory nitrate reductase

Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase.

Relation between anaerobic inactivation and oxygen tolerance in a large series of NiFe hydrogenase mutants

Roles of the F-domain in [FeFe] hydrogenase

SOAS: a free program to analyze electrochemical data and other one-dimensional signals

Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase

Steady-State Catalytic Wave-Shapes for 2-Electron Reversible Electrocatalysts and Enzymes

Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase

The Carbon Monoxide Dehydrogenase from Desulfovibrio vulgaris.