List of works - Susan A. Charman

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

scientific article

2,4-Diaminothienopyrimidines as orally active antimalarial agents

scientific article published on 28 January 2014

2,5-Dimethyl-2,4-hexadiene induced photodechlorination of 9,10-dichloroanthracene.

scientific article published on 23 April 2009

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

scientific article published on 05 March 2019

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

scientific article

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

scientific article published on 16 May 2013

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

scientific article published on 6 August 2015

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A prodrug approach toward cancer-related carbonic anhydrase inhibition.

scientific article

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

scientific article published on 24 May 2017

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

scientific article (publication date: 9 December 2016)

Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin

scientific article published in February 2006

An in vitro toolbox to accelerate anti-malarial drug discovery and development

scientific article published on 02 January 2020

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

scientific article

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

scientific article published on 22 August 2006

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. ⬇️

scientific article

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

scientific article

Antimalarial pyrido[1,2-a]benzimidazoles

scientific article published on 16 June 2011

Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease

scientific article

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

scientific article published on 11 January 2018

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

scientific article published on 30 August 2012

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

scientific article

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.

scientific article

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

scientific article

Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

scientific article published on 15 March 2013

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

scientific article published on 7 May 2007

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

scientific article

Computational prediction of CNS drug exposure based on a novel in vivo dataset.

scientific article published on 29 June 2012

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

scientific article published on 25 May 2016

Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii

scientific article published on 10 November 2018

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.

scientific article published on 31 January 2013

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

scientific article

Discovery and structure-activity relationships of pyrrolone antimalarials

scientific article

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

scientific article published on 17 July 2019

Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria

scientific article

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers

scientific article

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

scientific article

Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties

scientific article published on 6 April 2015

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

scientific article

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria"

scientific article published on 24 October 2018

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

scientific article published on 26 February 2019

Evidence for the in vitro bioactivation of aminopyrazole derivatives: trapping reactive aminopyrazole intermediates using glutathione ethyl ester in human liver microsomes

scientific article published on 28 August 2015

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials

scientific article published on 22 May 2019

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

scientific article published on February 2013

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

scientific article

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

scientific article published on 16 December 2015

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

scientific article published on 22 August 2016

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

scientific article published on 17 October 2016

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

scientific article published on April 2009

Impact of Cremophor-EL and Polysorbate-80 on Digoxin Permeability across Rat Jejunum: Delineation of Thermodynamic and Transporter Related Events Using the Reciprocal Permeability Approach

scientific article published on 01 February 2007

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

scientific article

Inhibition of Cytomegalovirus Replication with Extended Half-Life Synthetic Ozonides ⬇️

scientific article published on 21 December 2018

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

scientific article published in Nature

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities

scientific article

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

scientific article published in November 2007

Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt

scientific article published in August 2005

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

scientific article published on 06 April 2020

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

scientific article

Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model

article

Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model

scientific article published on 01 November 2001

Lymphatic absorption is the primary contributor to the systemic availability of epoetin Alfa following subcutaneous administration to sheep.

scientific article published on 3 December 2004

Lymphatic transport of proteins after s.c. injection: implications of animal model selection.

scientific article

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

scientific article

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

scientific article

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

scientific article published on 30 March 2022

Metallocene-Based Inhibitors of Cancer-Associated Carbonic Anhydrase Enzymes IX and XII

scientific article published on 22 May 2012

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

scientific article published on 17 October 2016

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>

scientific article published on 23 February 2021

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

scientific article published on 18 July 2019

Novel Toxoplasma gondii inhibitor chemotypes.

scientific article published on 25 October 2017

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans

scientific article published on 11 December 2016

Novel orally active antimalarial thiazoles

scientific article

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

scientific article published on 14 September 2016

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium

scientific article

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

scientific article published on 05 June 2019

Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum

scientific article published on 02 December 2019

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.

scientific article published on 20 December 2017

Permeability assessment of poorly water-soluble compounds under solubilizing conditions: the reciprocal permeability approach.

scientific article published in October 2006

Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats

scientific article published on 01 February 2008

Pharmacokinetics of recombinant human leukemia inhibitory factor in sheep.

scientific article published on 10 February 2004

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

scientific article published on 20 April 2021

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

scientific article

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system.

scientific article published on November 2010

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

scientific article published on 12 March 2021

Probing a Potential In Vivo Drug–Excipient Interaction: Temporal Effects of a Modified β-Cyclodextrin on the Intravenous Pharmacokinetics of a Model High-Affinity Drug Ligand

scientific article published on 01 May 2012

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

scientific article

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.

scientific article

Quinolone-3-diarylethers: a new class of antimalarial drug.

scientific article published in March 2013

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

scientific article

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

scientific article published on 11 February 2008

S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases

scientific article

SAR of a new antischistosomal urea carboxylic acid

scientific article published on 25 October 2018

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis

scientific article published on March 2017

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

scientific article published on October 2013

Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides

scientific article published on 20 October 2007

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

scientific article published on 9 July 2009

Stability of peroxide antimalarials in the presence of human hemoglobin

scientific article published on June 2009

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

scientific article

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

scientific article

Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines

scientific article

Structure-activity relationship studies of pyrrolone antimalarial agents

scientific article published on 05 August 2013

Subcutaneous drug delivery and the role of the lymphatics

scientific article published on January 2005

Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases

scientific article

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

scientific article

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria

scientific article published on 17 May 2018

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

scientific article

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

scientific article published on 26 June 2020

Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection

scientific article published on 01 February 2000

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

scientific article published on 29 April 2016

The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

scientific article published on 20 August 2019

The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep.

scientific article published on 9 August 2006

The binding interaction of synthetic ozonide antimalarials with natural and modified beta-cyclodextrins

scientific article published in January 2006

The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine

scientific article published in March 2012

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

scientific article

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

scientific article

Total synthesis of thiaplakortone a: derivatives as metabolically stable leads for the treatment of malaria

scientific article

Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations

scientific article

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

scientific article

Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.

scientific article published on 04 December 2013

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

scientific article published on 27 August 2018

Use of plasma proteins as solubilizing agents in in vitro permeability experiments: correction for unbound drug concentration using the reciprocal permeability approach

scientific article published in January 2008

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

scientific article published on 17 September 2018

List of works by Susan A. Charman

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

2,4-Diaminothienopyrimidines as orally active antimalarial agents

2,5-Dimethyl-2,4-hexadiene induced photodechlorination of 9,10-dichloroanthracene.

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

A novel multiple-stage antimalarial agent that inhibits protein synthesis

A prodrug approach toward cancer-related carbonic anhydrase inhibition.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin

An in vitro toolbox to accelerate anti-malarial drug discovery and development

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. ⬇️

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Antimalarial pyrido[1,2-a]benzimidazoles

Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

Computational prediction of CNS drug exposure based on a novel in vivo dataset.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

Discovery and structure-activity relationships of pyrrolone antimalarials

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria"

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

Evidence for the in vitro bioactivation of aminopyrazole derivatives: trapping reactive aminopyrazole intermediates using glutathione ethyl ester in human liver microsomes

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

Impact of Cremophor-EL and Polysorbate-80 on Digoxin Permeability across Rat Jejunum: Delineation of Thermodynamic and Transporter Related Events Using the Reciprocal Permeability Approach

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Inhibition of Cytomegalovirus Replication with Extended Half-Life Synthetic Ozonides ⬇️

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model

Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model

Lymphatic absorption is the primary contributor to the systemic availability of epoetin Alfa following subcutaneous administration to sheep.

Lymphatic transport of proteins after s.c. injection: implications of animal model selection.

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

Metallocene-Based Inhibitors of Cancer-Associated Carbonic Anhydrase Enzymes IX and XII

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

Novel Toxoplasma gondii inhibitor chemotypes.

Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans

Novel orally active antimalarial thiazoles

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.