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List of works by Isabel Fabregat

2-[18F]FDG PET/CT as a Predictor of Microvascular Invasion and High Histological Grade in Patients with Hepatocellular Carcinoma

scientific article published in 2021

A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells

scientific article published on 04 August 2014

A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins

scientific article (publication date: 15 September 2014)

Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism

scientific article published on July 2007

Altered TGF-β endocytic trafficking contributes to the increased signaling in Marfan syndrome

scientific article published on 23 November 2017

Apoptosis Induced by Transforming Growth Factor- in Fetal Hepatocyte Primary Cultures

scientific article published in Journal of Biological Chemistry

Apoptotic Response to TGF-$beta; in Fetal Hepatocytes Depends upon Their State of Differentiation

scientific article published on 01 November 1999

Apoptotic action of E2F1 requires glycogen synthase kinase 3-beta activity in PC12 cells

scientific article published on 7 June 2007

Autocrine production of TGF-β confers resistance to apoptosis after an epithelial–mesenchymal transition process in hepatocytes: Role of EGF receptor ligands

scientific article published on 07 June 2006

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

scientific article

BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation

scientific article published on 28 August 2015

BMPS and liver: more questions than answers

scientific article published on January 2012

Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC-induced cholestatic liver injury.

scientific article

Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC

scientific article published on 18 October 2019

Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.

scientific article

Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1.

scientific article published on 27 January 2016

Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo.

scientific article

Changes in rat liver gene expression induced by thioacetamide: protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism

scientific article published on 01 March 1996

Citrate synthase of Tetrahymena pyriformis: Evolutionary and regulatory aspects

scientific article published on 01 February 1983

Clathrin switches transforming growth factor-β role to pro-tumorigenic in liver cancer

scientific article published on 25 September 2019

Correction: Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.

scientific article published on 30 July 2013

Cross-Talk Between TGF-β and NADPH Oxidases During Liver Fibrosis and Hepatocarcinogenesis

scientific article

Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture.

scientific article published on October 1997

Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro

scientific article published on April 2008

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.

scientific article

Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.

scientific article published on 16 September 2006

Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones

scientific article published on 01 October 1992

Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

scientific article published on 13 December 2010

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.

scientific article published on 27 August 2015

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition

scientific article published on 26 August 2019

Dysregulation of apoptosis in hepatocellular carcinoma cells

scientific article published in February 2009

EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death.

scientific article

EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells

scientific article published on 7 October 2011

Editorial Special Issue TGF-beta/BMP Signaling Pathway

scientific article published on 27 October 2020

Effects of growth and differentiation factors on the epithelial-mesenchymal transition in cultured neonatal rat hepatocytes

scientific journal article

Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase

scientific article published on 16 December 2005

Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

scientific article published on 01 September 2000

Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture

article

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

scientific article published on 18 May 2017

Exploring liver physiology, pathology, TGF-β, EMT, stemness and new developments in liver cancer.

scientific article published in January 2017

Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture.

scientific article published in February 2000

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression

scientific article published on 7 March 2018

Genetically modified animal models recapitulating molecular events altered in human hepatocarcinogenesis

scientific article published on April 2009

Glucocorticoid receptor down-Regulates c-jun amino terminal kinases induced by tumor necrosis factor ? in fetal rat hepatocyte primary cultures

article

Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.

scientific article

Growth factor- and cytokine-driven pathways governing liver stemness and differentiation ⬇️

scientific article published on November 7, 2010

Growth stimulation of rat fetal hepatocytes in response to hepatocyte growth factor: modulation of c-myc and c-fos expression

scientific article published on December 15, 1992

HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.

scientific article

Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion

scientific article published in January 2006

Hepatocyte growth factor up-regulates met expression in rat fetal hepatocytes in primary culture

scientific journal article

Hormonal regulation of malic enzyme expression in primary cultures of foetal brown adipocytes

article

Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFβ inhibitors to hepatocellular carcinoma cells

scientific article

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

scientific article published in December 2004

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

scientific article published on 20 April 2013

Inhibition of fatty acid biosynthesis by bezafibrate in different rat cells

scientific article published on 01 August 1989

Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion

scientific article

Interaction with protein SH groups could be involved in adriamycin cardiotoxicity ⬇️

scientific article published on December 1, 1984

Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes

scientific journal article

Isolation and characterization of a putative liver progenitor population after treatment of fetal rat hepatocytes with TGF-beta

scientific journal article

Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells.

scientific article published on 22 September 2011

Lack of aminoacids in mouse hepatocytes in culture induces the selection of preneoplastic cells

scientific article

Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation

scientific journal article

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.

scientific article published on 18 September 2003

Mechanisms regulating cell membrane localization of the chemokine receptor CXCR4 in human hepatocarcinoma cells.

scientific article

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes

scientific article published in September 2003

Mouse hepatic oval cells require Met-dependent PI3K to impair TGF-β-induced oxidative stress and apoptosis

scientific article

NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice

scientific article published on 23 December 2020

NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathway

scientific article

NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.

scientific article

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer

scientific article

Noradrenergic modulation of albumin expression in growth-stimulated adult rat hepatocytes in primary culture

article

Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

scientific article published on 22 September 2009

Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells.

scientific article published on 11 October 2013

Paradoxical role of the NADPH oxidase NOX4 in early preneoplastic stages of hepatocytes induced by amino acid deprivation

scientific article published on 29 January 2019

Phorbol esters down-regulate alpha-fetoprotein gene expression without affecting growth in fetal hepatocytes in primary culture

scientific article published in March 1998

Polμ deficiency increases resistance to oxidative damage and delays liver aging

scientific article

Possible involvement of NADPH requirement in regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenase levels in rat liver

scientific article

Precocious induction of malic enzyme by nutritional and hormonal factors in rat foetal hepatocyte primary cultures

article

Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes

scientific article

ROS production is essential for the apoptotic function of E2F1 in pheochromocytoma and neuroblastoma cell lines

scientific article

Rates of lipogenesis in fetal hepatocytes in suspension and in primary culture: hormonal effects

scientific article published in August 1989

Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.

scientific article published in March 2001

Reciprocal regulation of NADPH oxidases and the cyclooxygenase-2 pathway

scientific article published on 19 August 2011

Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm.

scientific article published on 19 February 2018

Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones

scientific article published on July 1, 1992

Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: Role of epidermal growth factor and dexamethasone

article

Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone

scientific article published on 01 December 1995

Resistance to TGF-beta-induced apoptosis in regenerating hepatocytes

scientific article published in December 2004

Resminostat induces changes in epithelial plasticity of hepatocellular carcinoma cells and sensitizes them to sorafenib-induced apoptosis.

scientific article published on 30 November 2017

Revisiting the liver: from development to regeneration - what we ought to know!

scientific article published on 01 January 2018

Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta

scientific article

Role of NADPH oxidases in the redox biology of liver fibrosis

scientific article

Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.

scientific article published on 2 October 2017

Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma

scientific article published on April 2014

Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.

scientific article

Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes

scientific article published on 01 July 1987

Snail blocks the cell cycle and confers resistance to cell death

scientific journal article

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

scientific article published on 11 December 2017

Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes

scientific article published on October 2010

Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli.

scientific article

Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes

scientific article

Study of the inhibition produced by adriamycin against specific enzymes in the rat heart

scientific article published on January 1982

Survival and apoptosis: a dysregulated balance in liver cancer

scientific article published on March 2007

Syndecan-2 expression increases serum-withdrawal-induced apoptosis, mediated by re-distribution of Fas into lipid rafts, in stably transfected Swiss 3T3 cells

scientific article published on November 2006

TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells

scientific article published on 20 February 2007

TGF-beta signaling in cancer treatment

scientific article published on January 2014

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.

scientific article published on 26 April 2018

TGF-β signalling and liver disease.

scientific article

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men

scientific article published on 21 January 2016

The NADPH consumption regulates the NADPH-producing pathways (pentose phosphate cycle and malic enzyme) in rat adipocytes

scientific article published on 01 March 1987

The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression

scientific article published on 6 February 2014

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.

scientific article published on 12 December 2016

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells ⬇️

scientific article published on January 26, 2011

The TGF-β pathway: a pharmacological target in hepatocellular carcinoma?

scientific article published on 01 April 2017

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes

scientific article published on 01 November 2002

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

scientific journal article

The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells.

scientific article

The pentose phosphate cycle is regulated by NADPHNADP ratio in rat liver

scientific article published on 01 January 1985

The rationale for targeting TGF-β in chronic liver diseases.

scientific article published on 29 January 2016

The role of NADPH in the regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rat adipose tissue

scientific article (publication date: 26 June 1991)

The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells.

scientific article

The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.

scientific article

Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis

scientific article published on 10 September 2018

Transforming growth factor ? modulates growth and differentiation of fetal hepatocytes in primary culture

scientific article published on 01 November 1995

Transforming growth factor-beta (TGF-beta) and EGF promote cord-like structures that indicate terminal differentiation of fetal hepatocytes in primary culture.

scientific article

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes

scientific article

Transforming growth factor-β-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma.

scientific article published on February 2017

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

scientific journal article

Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.

scientific article

Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.

scientific article published in January 2003

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a neuropeptide antagonist, blocks binding, Ca2(+)-mobilizing, and mitogenic effects of endothelin and vasoactive intestinal contractor in mouse 3T3 cells.

scientific article published on October 1990

c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition and Regulates Cell Phenotypic Switch.

scientific article

c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver

scientific article

cIAP-1, but not XIAP, is cleaved by caspases during the apoptosis induced by TGF-beta in fetal rat hepatocytes

scientific article

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