List of works - Manus W. Ward

'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

scientific article published on 7 February 2012

A CRIS in the Desert: The Implementation of Pure at KAUST A Case Study in Information Exchange

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

scientific article

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF

scientific article

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

scientific article published on 31 December 2010

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

scientific article published on February 2012

Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.

scientific article published on 4 October 2010

Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.

scientific article published on 2 May 2008

Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability

scientific article published on 30 April 2010

Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.

scientific article

Excitotoxic injury to mitochondria isolated from cultured neurons.

scientific article published on 2 June 2005

Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange

scientific article published on 13 June 2010

Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons

scientific article

Glutamate excitotoxicity and neuronal energy metabolism

scientific article published on 01 January 1999

High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer

scientific article published in May 2002

Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.

scientific article published on 29 September 2004

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. ⬇️

scientific article

Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype.

scientific article

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.

scientific article published in August 2007

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)

scientific article published on 8 November 2006

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

scientific article

Neuronal apoptosis: BH3-only proteins the real killers?

scientific article

Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells.

scientific article published on April 1999

Quantitative analysis of membrane potentials

scientific article published on 01 January 2010

Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis

scientific article published on 28 December 2005

Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.

scientific article

Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

scientific article published on 18 February 2011

Suppression of two cloned smooth muscle-derived delayed rectifier potassium channels by cholinergic agonists and phorbol esters

scientific article published on December 1995

TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.

scientific article published on 7 September 2008

List of works by Manus W. Ward

'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

A CRIS in the Desert: The Implementation of Pure at KAUST A Case Study in Information Exchange

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.

Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.

Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.

Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability

Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.

Excitotoxic injury to mitochondria isolated from cultured neurons.

Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange

Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons

Glutamate excitotoxicity and neuronal energy metabolism

High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer

Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. ⬇️

Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype.

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

Neuronal apoptosis: BH3-only proteins the real killers?

Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells.

Quantitative analysis of membrane potentials

Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis

Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.

Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

Suppression of two cloned smooth muscle-derived delayed rectifier potassium channels by cholinergic agonists and phorbol esters

TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.