List of works - Emre M. Isin

A novel and selective monoamine oxidase B substrate.

scientific article published in October 2005

Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.

scientific article published on 12 December 2012

Bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant

scientific article published on 6 July 2011

Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data

scientific article

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

scientific article

Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli

scientific article published on 22 October 2007

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

scientific article published on 31 May 2012

Introduction: Mass Spectrometry and Emerging Technologies for Biomarker Discovery in the Assessment of Human Health and Disease

scientific article

Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation

scientific article published on 01 May 2006

Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

scientific article published on 8 February 2006

Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2).

scientific article published in June 2006

Model electrochemical-mass spectrometric studies of the cytochrome P450-catalyzed oxidations of cyclic tertiary allylamines

scientific article published in September 2005

Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4

scientific article published on 02 January 2007

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.

scientific article

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

scientific article published on 11 November 2010

Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes

scientific article

Substrate binding to cytochromes P450.

scientific article published on 13 July 2008

The tert-butoxyl radical mediated hydrogen atom transfer reactions of the Parkinsonian proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and selected tertiary amines.

scientific article

Use of electrochemical oxidation and model peptides to study nucleophilic biological targets of reactive metabolites: the case of rimonabant

scientific article

Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies

scientific article published on 28 February 2012

List of works by Emre M. Isin

A novel and selective monoamine oxidase B substrate.

Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.

Bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant

Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

Introduction: Mass Spectrometry and Emerging Technologies for Biomarker Discovery in the Assessment of Human Health and Disease

Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation

Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2).

Model electrochemical-mass spectrometric studies of the cytochrome P450-catalyzed oxidations of cyclic tertiary allylamines

Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes

Substrate binding to cytochromes P450.

The tert-butoxyl radical mediated hydrogen atom transfer reactions of the Parkinsonian proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and selected tertiary amines.

Use of electrochemical oxidation and model peptides to study nucleophilic biological targets of reactive metabolites: the case of rimonabant

Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies