List of works - Andreas Link

1,2,4-trisubstituted cyclopentanes as platforms for diversity

scientific article

4-Aminocyclopentane-1,3-diols as platforms for diversity: synthesis of anandamide analogs.

scientific article

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

scientific article published in April 2002

A timely reassessment of early prediction in the bioavailability of orally administered drugs.

scientific article published on July 2005

Advances in the design of a multipurpose fragment screening library.

scientific article

Anti-malarial activity of N(6)-substituted adenosine derivatives. Part I.

scientific article published in March 2002

Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3.

scientific article published in February 2004

Antimalarial activity of n(6)-substituted adenosine derivatives (part 2).

scientific article published in July 2002

Antitumor pyrido[3,2-d][1]benzazepines: synthesis and in vitro activity of thiophene analogs

scientific article published on March 1999

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

scientific article published on 16 September 2019

Centennial Anniversary of Mannich's Report on the Formation of β-Amino-Ketones in the Archiv der Pharmazie

scientific article published on 01 July 2017

Comments on the Terminology for Applications of Temporarily Attached Solubility-Modifying Moieties in Combinatorial Chemistry

scientific article published on 01 November 2000

Crystal structure of 7,8,15,16,17-penta-thiadi-spiro-[5.2.59.36]hepta-deca-ne

scientific article published on 24 May 2019

Crystal structure of benzo[h]quinoline-3-carbox-amide

scientific article published on 05 November 2019

DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

Designs that enrich lives

scientific article published on 01 October 2007

Dynamite approach to delicate complex scaffolds

scientific article published on 01 May 2002

Evaluation of (S)- and (R)-misonidazole as GPX inhibitors: synthesis, characterization including circular dichroism and in vitro testing on bovine GPx-1.

scientific article published on 27 December 2013

Exploration of the effect of sterically demanding 3'-amido substitution of 3'-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.

scientific article published in October 1999

Flupirtine Analogues: Explorative Synthesis and Influence of Chemical Structure on K7.2/K7.3 Channel Opening Activity

Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators

scientific article published on 01 May 2019

G-Protein-Coupled Receptors: Sustained Signaling via Intracellular Megaplexes and Pathway-Specific Drugs

scientific article published on 24 October 2016

Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker

scientific article published in January 2002

Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines.

scientific article published on 26 June 2009

Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives

scientific article published on 20 January 2009

Interconnection of sulfides and sulfoxides in medicinal chemistry

scientific article published on 06 December 2018

Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection

scientific article

Lead Optimization ofN6-Cyclopentyl-3′-amido-3′-deoxyxylofuranosyladenines as Adenosine A1Receptor Antagonists

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones

scientific article published on 07 February 2006

Microwave-assisted synthesis and evaluation of acylhydrazones as potential inhibitors of bovine glutathione peroxidase

scientific article published on 19 January 2014

N-acyl-N-alkyl-sulfonamide anchors derived from Kenner's safety-catch linker: powerful tools in bioorganic and medicinal chemistry.

scientific article

Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides

scientific article

O,N,N'-trialkylisoureas as mild activating reagents for N-acylsulfonamide anchors

scientific article published on 01 December 2005

Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.

scientific article

Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides.

scientific article

Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites.

scientific article published on 30 May 2009

Polymer-assisted solution-phase synthesis of 2'-amido-2'-deoxyadenosine derivatives targeted at the NAD(+)-binding sites of parasite enzymes.

scientific article

Polymer-bound reagents for the introduction of spacer-modified biotin labels.

scientific article

Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines

Practical synthesis of fenbufen ethanolamide.

scientific article published in October 2004

Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples

scientific article published on 27 February 2017

Replica-Based Protein Structure Sampling Methods II: Advanced Hybrid Solvent TIGER2hs

scientific article published on 02 July 2019

Short synthesis of ethyl 3-(3-aminophenyl)propanoate

scientific article published on 12 October 2011

Simultaneous quantification of acidic and basic flupirtine metabolites by supercritical fluid chromatography according to European Medicines Agency validation

scientific article published on 25 April 2019

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

scientific article (publication date: April 2003)

Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases

scientific article published on 10 October 2019

Subcritical Fluid Chromatography at Sub-Ambient Temperatures for the Chiral Resolution of Ketamine Metabolites with Rapid-Onset Antidepressant Effects.

scientific article published on 19 May 2019

Substituted tetrazoles as multipurpose screening compounds.

scientific article

Sulfide Analogues of Flupirtine and Retigabine with Nanomolar KV 7.2/KV 7.3 Channel Opening Activity

scientific article published on 02 April 2019

Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS).

scientific article published in February 2018

Sustainable synthesis and automated deposition: an accessible discovery screening library of fragment-like purines.

scientific article

Synthesis and antimalarial activity of novel N6-substituted adenosine derivatives.

scientific article published in May 2003

Synthesis and antiplasmodial activity of new N-[3-(4-{3-[(7-chloroquinolin-4-yl)amino]propyl}piperazin-1-yl)propyl]carboxamides

scientific article published on 24 December 2006

Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins)

scientific article published on 22 January 2011

Synthesis and potassium K7 channel opening activity of thioether analogues of the analgesic flupirtine

scientific article published on 01 November 2018

Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.

scientific article published on 30 October 2009

Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites

scientific article published on 20 February 2009

Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

scientific article published on 8 December 2007

Tetrahydroindoles as Multipurpose Screening Compounds and Novel Sirtuin Inhibitors

scientific article published on 21 March 2019

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

scientific article

The many (inter-)faces of supercritical fluid chromatography: the present and future prospects of online supercritical fluid extraction-supercritical fluid chromatography

article

Three-Component Aminoalkylations Yielding Dihydronaphthoxazine-Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side-Chains.

scientific article published on 26 May 2017

Towards a European strategy for medicines research (2014-2020): The EUFEPS position paper on Horizon 2020.

scientific article published on 6 October 2012

Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors

scientific article published in April 2008

Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform

scientific article

[Calcium salts: fantastic and enlightening].

scientific article published in January 2009

[Elemental iron and iron oxides in new applications]

scientific article published on 01 January 2009

[Pharmazie in unserer Zeit 3/2009]

scientific article published on 01 January 2009

d-Fused [1]benzazepines with selective in vitro antitumor activity: synthesis and structure-activity relationships

scientific article published on 01 April 1998

List of works by Andreas Link

1,2,4-trisubstituted cyclopentanes as platforms for diversity

4-Aminocyclopentane-1,3-diols as platforms for diversity: synthesis of anandamide analogs.

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

A timely reassessment of early prediction in the bioavailability of orally administered drugs.

Advances in the design of a multipurpose fragment screening library.

Anti-malarial activity of N(6)-substituted adenosine derivatives. Part I.

Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3.

Antimalarial activity of n(6)-substituted adenosine derivatives (part 2).

Antitumor pyrido[3,2-d][1]benzazepines: synthesis and in vitro activity of thiophene analogs

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

Centennial Anniversary of Mannich's Report on the Formation of β-Amino-Ketones in the Archiv der Pharmazie

Comments on the Terminology for Applications of Temporarily Attached Solubility-Modifying Moieties in Combinatorial Chemistry

Crystal structure of 7,8,15,16,17-penta-thiadi-spiro-[5.2.59.36]hepta-deca-ne

Crystal structure of benzo[h]quinoline-3-carbox-amide

DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

Designs that enrich lives

Dynamite approach to delicate complex scaffolds

Evaluation of (S)- and (R)-misonidazole as GPX inhibitors: synthesis, characterization including circular dichroism and in vitro testing on bovine GPx-1.

Exploration of the effect of sterically demanding 3'-amido substitution of 3'-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.

Flupirtine Analogues: Explorative Synthesis and Influence of Chemical Structure on K7.2/K7.3 Channel Opening Activity

Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators

G-Protein-Coupled Receptors: Sustained Signaling via Intracellular Megaplexes and Pathway-Specific Drugs

Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker

Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines.

Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives

Interconnection of sulfides and sulfoxides in medicinal chemistry

Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection

Lead Optimization ofN6-Cyclopentyl-3′-amido-3′-deoxyxylofuranosyladenines as Adenosine A1Receptor Antagonists

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones

Microwave-assisted synthesis and evaluation of acylhydrazones as potential inhibitors of bovine glutathione peroxidase

N-acyl-N-alkyl-sulfonamide anchors derived from Kenner's safety-catch linker: powerful tools in bioorganic and medicinal chemistry.

Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides

O,N,N'-trialkylisoureas as mild activating reagents for N-acylsulfonamide anchors

Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.

Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides.

Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites.

Polymer-assisted solution-phase synthesis of 2'-amido-2'-deoxyadenosine derivatives targeted at the NAD(+)-binding sites of parasite enzymes.

Polymer-bound reagents for the introduction of spacer-modified biotin labels.

Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines

Practical synthesis of fenbufen ethanolamide.

Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples

Replica-Based Protein Structure Sampling Methods II: Advanced Hybrid Solvent TIGER2hs

Short synthesis of ethyl 3-(3-aminophenyl)propanoate

Simultaneous quantification of acidic and basic flupirtine metabolites by supercritical fluid chromatography according to European Medicines Agency validation

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases

Subcritical Fluid Chromatography at Sub-Ambient Temperatures for the Chiral Resolution of Ketamine Metabolites with Rapid-Onset Antidepressant Effects.

Substituted tetrazoles as multipurpose screening compounds.

Sulfide Analogues of Flupirtine and Retigabine with Nanomolar KV 7.2/KV 7.3 Channel Opening Activity

Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS).

Sustainable synthesis and automated deposition: an accessible discovery screening library of fragment-like purines.

Synthesis and antimalarial activity of novel N6-substituted adenosine derivatives.

Synthesis and antiplasmodial activity of new N-[3-(4-{3-[(7-chloroquinolin-4-yl)amino]propyl}piperazin-1-yl)propyl]carboxamides

Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins)

Synthesis and potassium K7 channel opening activity of thioether analogues of the analgesic flupirtine

Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.

Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites

Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

Tetrahydroindoles as Multipurpose Screening Compounds and Novel Sirtuin Inhibitors

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

The many (inter-)faces of supercritical fluid chromatography: the present and future prospects of online supercritical fluid extraction-supercritical fluid chromatography

Three-Component Aminoalkylations Yielding Dihydronaphthoxazine-Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side-Chains.

Towards a European strategy for medicines research (2014-2020): The EUFEPS position paper on Horizon 2020.

Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors

Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform

[Calcium salts: fantastic and enlightening].

[Elemental iron and iron oxides in new applications]

[Pharmazie in unserer Zeit 3/2009]

d-Fused [1]benzazepines with selective in vitro antitumor activity: synthesis and structure-activity relationships