List of works by William D. Lubell

1,3,5-Tri- and 1,3,4,5-tetra-substituted 1,4-diazepin-2-one solid-phase synthesis.

scientific article published on 8 August 2008

1,3,5-trisubstituted 1,4-diazepin-2-ones

scientific article published on 10 October 2007

1,4-Diazepinone and pyrrolodiazepinone syntheses via homoallylic ketones from cascade addition of vinyl Grignard reagent to alpha-aminoacyl-beta-amino esters

scientific article published on 01 August 2006

2-vinylpyrroles and pyrrolo[3,2-d]pyrimidines from direct addition of aldehydes to 4-amino-pyrrole-2-carboxylate derivatives

scientific article published on 31 January 2008

4-Vinylproline

scientific article published on 11 October 2018

4-alkoxy- and 4-amino-2,2'-bipyrrole synthesis

scientific article published on 01 December 2006

9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitrogen protecting group

scientific article published in January 2006

A critical role of interleukin-1 in preterm labor.

scientific article

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway

scientific article

Adiponectin has a pivotal role in the cardioprotective effect of CP-3(iv), a selective CD36 azapeptide ligand, after transient coronary artery occlusion in mice

scientific article published on 10 October 2017

Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of Their N-Acetyl N'-Methylamides

scientific article

Amino acid-azetidine chimeras: synthesis of enantiopure 3-substituted azetidine-2-carboxylic acids.

scientific article published in February 2005

An Olefination Entry for the Synthesis of Enantiopure alpha,omega-Diaminodicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids.

scientific article

An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration

scientific article published on 27 November 2020

An effective new synthesis of 4-aminopyrrole-2-carboxylates

scientific article published on 01 July 2002

Analysis of N-amino-imidazolin-2-one peptide turn mimic 4-position substituent effects on conformation by X-ray crystallography

scientific article published in January 2014

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny

scientific article published in Scientific Reports

Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice

scientific article published on February 2017

Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo

scientific article published on 15 November 2019

Application of constrained aza-valine analogs for Smac mimicry

scientific article published on 01 May 2016

Applications of γ,δ-Unsaturated Ketones Synthesized by Copper-Catalyzed Cascade Addition of Vinyl Grignard Reagents to Esters

article

Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice

scientific article published on 06 July 2020

Author Correction: Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny

scientific article published on 15 April 2020

Aza-1,2,3-triazole-3-alanine synthesis via copper-catalyzed 1,3-dipolar cycloaddition on aza-progargylglycine.

scientific article published in August 2010

Aza-amino acid scan for rapid identification of secondary structure based on the application of N-Boc-aza(1)-dipeptides in peptide synthesis

scientific article published in June 2004

Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands.

scientific article

Aza-amino acid scanning of secondary structure suited for solid-phase peptide synthesis with fmoc chemistry and aza-amino acids with heteroatomic side chains

scientific article

Aza-scanning of the potent melanocortin receptor agonist Ac-His-D-Phe-Arg-Trp-NH

scientific article published on 01 April 2006

Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications.

scientific article

Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.

scientific article

Azapeptides and their therapeutic potential.

scientific article published on July 2011

Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization

scientific article published on 22 October 2018

Azopeptides: Synthesis and Pericyclic Chemistry

scientific article published on 28 October 2015

Benzophenone semicarbazone protection strategy for synthesis of aza-glycine containing aza-peptides

scientific article

Beta,beta-disubstituted C- and N-vinylindoles from one-step condensations of aldehydes and indole derivatives.

scientific article published in August 2009

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila.

scientific article

Bis(pyrrol-2-yl)arylenes from the tandem bidirectional addition of vinyl Grignard reagent to aryl diesters.

scientific article published in September 2005

CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits.

scientific article published on December 2010

Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor

scientific article published on 24 February 2007

Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates

scientific article published on 2 December 2015

Cinnamoyl inhibitors of tissue transglutaminase.

scientific article published on 27 June 2008

Conformationally constrained dipeptide surrogates with aromatic side-chains: synthesis of 4-aryl indolizidin-9-one amino acids by conjugate addition to a common alpha,omega-diaminoazelate enone intermediate.

scientific article published in March 2004

Conjugated 4-methoxybipyrrole thiophene azomethines: synthesis, opto-electronic properties, and crystallographic characterization

scientific article published on 31 August 2011

Copper-catalyzed N-arylation of semicarbazones for the synthesis of aza-arylglycine-containing aza-peptides.

scientific article published in July 2010

Crystal structure analyses of azasulfuryltripeptides reveal potential for γ-turn mimicry

scientific article published on 01 September 2015

Cyclic Aza-peptide Integrin Ligand Synthesis and Biological Activity

scientific article published on 4 June 2012

Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics

scientific article published on 18 October 2019

De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo

scientific article published on 18 May 2015

Deazapurine solid-phase synthesis: combinatorial synthesis of a library of N3,N5,C6-trisubstituted pyrrolo[3,2-d]pyrimidine derivatives on cross-linked polystyrene bearing a cysteamine linker

scientific article

Deazapurine solid-phase synthesis: construction of 3-substituted pyrrolo[3,2-d]pyrimidine-6-carboxylates on cross-linked polystyrene bearing a cysteamine linker

scientific article published in July 2005

Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells.

scientific article

Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics.

scientific article published on 13 November 2017

Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics

scientific article

Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics.

scientific article

Development of a novel noncompetitive antagonist of IL-1 receptor

scientific article published on 01 May 2008

Diastereoselective Pictet-Spengler approach for the synthesis of pyrrolo[3,2-e][1,4]diazepin-2-one peptide turn mimics

scientific article published on 11 June 2008

Diversity-Oriented Syntheses of β-Substituted α-Amino γ-Lactam Peptide Mimics with Constrained Backbone and Side Chain Residues

scientific article published on 19 September 2018

Diversity-Oriented Synthesis of Cyclic Azapeptides by A3 -Macrocyclization Provides High-Affinity CD36-Modulating Peptidomimetics.

scientific article published on 16 January 2017

Diversity-oriented synthesis of azapeptides with basic amino acid residues: aza-lysine, aza-ornithine, and aza-arginine.

scientific article

Diversity-oriented synthesis of functionalized pyrrolo[3,2-d]pyrimidines with variation of the pyrimidine ring nitrogen substituents.

scientific article published in September 2003

Dynamic Chirality in the Mechanism of Action of Allosteric CD36 Modulators of Macrophage-Driven Inflammation

scientific article published on 13 December 2019

Effect of sequence on peptide geometry in 5-tert-butylprolyl type VI beta-turn mimics.

scientific article

Efficient synthesis of enantiopure pyrrolizidinone amino acid

scientific article published in September 2003

Examination of structural characteristics of the potent oxytocin antagonists [dPen1,Pen6]-OT and [dPen1,Pen6, 5-tBuPro7]-OT by NMR, Raman, CD spectroscopy and molecular modeling

scientific article

Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using β-amino γ-lactams

scientific article published on 04 February 2011

Examination of the potential for adaptive chirality of the nitrogen chiral center in aza-aspartame.

scientific article published on 28 November 2013

Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S

scientific article published on 01 October 2002

Exploring side-chain diversity by submonomer solid-phase aza-peptide synthesis

scientific article published on 01 August 2009

Fluorometric assay for tissue transglutaminase-mediated transamidation activity.

scientific article published on 18 July 2009

From macrocycle dipeptide lactams to azabicyclo[X.Y.0]alkanone amino acids: a transannular cyclization route for peptide mimic synthesis

scientific article published on 01 June 2006

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides

scientific article published on 23 January 2019

Heumann Indole Flow Chemistry Process

scientific article published on 08 August 2019

Homoserine-derived cyclic sulfamidate as chiral educt for the diversity-oriented synthesis of lactam-bridged dipeptides

scientific article published in January 2005

Immunometabolic modulation of retinal inflammation by CD36 ligand

scientific article published on 09 September 2019

Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

scientific article

Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns.

scientific article published in January 2010

Insight into Transannular Cyclization Reactions To Synthesize Azabicyclo[X.Y.Z]alkanone Amino Acid Derivatives from 8-, 9-, and 10-Membered Macrocyclic Dipeptide Lactams

scientific article published on 29 April 2015

Interleukin-1 Receptor Modulation Using β-Substituted α-Amino-γ-Lactam Peptides From Solid-Phase Synthesis and Diversification

scientific article published on 21 December 2020

Interleukin-1 and ischemic brain injury in the newborn: development of a small molecule inhibitor of IL-1 receptor

scientific article

Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor

scientific article published on 19 June 2015

Isolated α-turn and incipient γ-helix

scientific article published on 10 June 2019

Large structural modification with conserved conformation: analysis of delta(3)-fused aryl prolines in model beta-turns.

scientific article published in November 2004

Microglia and interleukin-1β in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A.

scientific article published on 13 June 2013

Microwave-assisted synthesis of rhodamine fluorescent tags

scientific article published on 01 January 2009

Mimicry of peptide backbone geometry and heteroatomic side-chain functionality: synthesis of enantiopure indolizidin-2-one amino acids possessing alcohol, acid, and azide functional groups.

scientific article published in February 2001

Mimics of peptide turn backbone and side-chain geometry by a general approach for modifying azabicyclo[5.3.0]alkanone amino acids

scientific article published on 22 June 2011

Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors.

scientific article

Multicomponent diversity-oriented synthesis of aza-lysine-peptide mimics.

scientific article

N-(9-(9-phenylfluorenyl))homoserine-derived cyclic sulfamidates: novel chiral educts for the synthesis of enantiopure gamma-substituted alpha-amino acids

scientific article published on 01 September 2001

N-Amino-imidazolin-2-one peptide mimic synthesis and conformational analysis.

scientific article published on 14 August 2012

N-Aminosulfamide peptide mimic synthesis by alkylation of aza-sulfurylglycinyl peptides

scientific article published on 13 February 2012

N-aminoimidazolidin-2-one peptidomimetics

scientific article published on 04 April 2014

Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth

scientific article published on 24 August 2015

One-pot synthesis of homoallylic ketones from the addition of vinyl grignard reagent to carboxylic esters

scientific article published on 01 December 2003

Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators That Delay Preterm Birth

scientific article published on 23 April 2019

Peptide chemistry

scientific article published on 01 September 2012

Peptide chemistry

Peptide scanning for studying structure-activity relationships in drug discovery

scientific article published on January 2013

Peptides in Paris

article

Peptides of life teaching peptide science and art in elementary school.

scientific article published in January 2009

Peptidomimetic Synthesis by Way of Diastereoselective Iodoacetoxylation and Transannular Amidation of 7-9-Membered Lactams.

scientific article

Photoacoustic FTIR Spectroscopy, a Nondestructive Method for Sensitive Analysis of Solid-Phase Organic Chemistry

scientific article published on 01 November 1996

Photolabeling of tissue transglutaminase reveals the binding mode of potent cinnamoyl inhibitors.

scientific article

Poly (vinyl alcohol)-graft-poly (ethylene glycol) supported hydroxyproline: synthesis and application in the enantioselective aldol condensation.

scientific article published in January 2009

Poly(vinyl alcohol)-graft-poly(ethylene glycol) resins and their use in solid-phase synthesis and supported TEMPO catalysis

scientific article

Poly-(Prophi[Ch(OAc)CH2]Aib)3 a protected trimer of Pro-Aib hydroxyethylene isosteres.

scientific article published in January 2009

Portraits of the pioneers of the American Peptide Society

scientific article published on 01 January 2009

Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides

scientific article

Preface

Preparation, characterization, and application of poly(vinyl alcohol)-graft-poly(ethylene glycol) resins: novel polymer matrices for solid-phase synthesis.

scientific article

Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands

article

Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist

scientific article published in November 2002

Pyrrole protection

article

Pyrrolo[3,2-e][1,4]diazepin-2-one synthesis: a head-to-head comparison of soluble versus insoluble supports

scientific article

Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure.

scientific article published on 14 November 2012

Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase.

scientific article

Rho signaling pathway targeted to promote spinal cord repair.

scientific article published in August 2002

Rigid Dipeptide Mimics: Synthesis of Enantiopure 5- and 7-Benzyl and 5,7-Dibenzyl Indolizidinone Amino Acids via Enolization and Alkylation of delta-Oxo alpha,omega-Di-[N-(9-(9-phenylfluorenyl))amino]azelate Esters

scientific article

Rigid dipeptide mimics: synthesis of enantiopure C6-functionalized pyrrolizidinone amino acids

scientific article published on 01 February 2007

SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis

scientific article published in September 2002

Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2.

scientific article published in September 2004

Serine as chiral educt for the practical synthesis of enantiopure N-protected beta-hydroxyvaline

scientific article

Site-specific protein propargylation using tissue transglutaminase.

scientific article

Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity

scientific article published in February 2010

Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation

scientific article published on 26 April 2019

Solid-phase synthesis of 1,3,5-trisubstituted 1,4-diazepin-2-one peptide mimic.

scientific article published in January 2009

Solid-phase synthesis of 3-aminopyrrole-2,5-dicarboxylate analogues

scientific article

Solid-phase synthesis of C-terminal azapeptides

scientific article published on 17 November 2014

Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis.

scientific article published in June 2010

Stereo- and Regiochemical Transannular Cyclization of a Common Hexahydro-1H-azonine to Afford Three Different Indolizidinone Dipeptide Mimetics

scientific article published on 15 November 2019

Structure-activity analysis of the growth hormone secretagogue GHRP-6 by alpha- and beta-amino gamma-lactam positional scanning

scientific article published on 01 January 2010

Structure-activity relationships of GHRP-6 azapeptide ligands of the CD36 scavenger receptor by solid-phase submonomer azapeptide synthesis

scientific article published on 21 July 2011

Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2.

scientific article published in March 2004

Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-Based Resins in Silicon Oil: Beaded SPOCC 1500 and POEPOP 1500.

scientific article

Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36)

scientific article published on 23 July 2020

Synthesis and alkylation of Aza-Gly-Pro building blocks of peptidomimetic libraries for developing prostaglandin F2α receptor modulators as therapeutics to inhibit preterm labor.

scientific article published on January 2015

Synthesis and alkylation of aza-glycinyl dipeptide building blocks.

scientific article

Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters.

scientific article published on October 2004

Synthesis and peptide coupling of protected pyrrolylalanine.

scientific article published in January 2009

Synthesis and pharmacology of new enantiopure delta(3)-4-arylkainoids.

scientific article

Synthesis of a new pi-deficient phenylalanine derivative from a common 1,4-diketone intermediate and study of the influence of aromatic density on prolyl amide isomer population.

scientific article published in January 2007

Synthesis of enantiopure 7-[3-azidopyl]indolizidin-2-one amino acid. A constrained mimic of the peptide backbone geometry and heteroatomic side-chain functionality of the ala-lys dipeptide.

scientific article published in February 2001

Synthesis of fused heteroarylprolines and pyrrolopyrroles

scientific article published in July 2004

Synthesis of protected 2-pyrrolylalanine for peptide chemistry and examination of its influence on prolyl amide isomer equilibrium

scientific article

Synthesis of pyrrolo[3,2-e] [1,4]diazepin-2-ones as potential gamma-turn mimetics

scientific article published on 01 January 2009

Systematic study of the synthesis of macrocyclic dipeptide beta-turn mimics possessing 8-, 9-, and 10- membered rings by ring-closing metathesis

scientific article published in May 2005

THG113: a novel selective FP antagonist that delays preterm labor

scientific article published on December 2002

Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.

scientific article published on 9 August 2011

The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress

scientific article published on 28 March 2021

Thoughts on Meldal and Hirschmann

scientific article published in January 2010

Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters.

scientific article

Unsymmetric electronic push-pull bipyrroles - synthesis, spectroelectrochemical, and photophysical investigation

scientific article published on 01 December 2009

Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity.

scientific article published on 3 May 2016

Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II.

scientific article

Use of Steric Interactions To Control Peptide Turn Geometry. Synthesis of Type VI beta-Turn Mimics with 5-tert-Butylproline.

scientific article

X-ray structure analysis reveals β-turn mimicry by N-amino-imidazolidin-2-ones

scientific article published on 01 September 2015

alpha-Amino-beta-hydroxy-gamma-lactam for constraining peptide Ser and Thr residue conformation.

scientific article published in April 2010

γ-Turn Mimicry with Benzodiazepinones and Pyrrolobenzodiazepinones Synthesized from a Common Amino Ketone Intermediate

scientific article published on 30 June 2015

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