Search filters

List of works by Michel Vidal

A HPLC-fluorescence method for the quantification of abiraterone in plasma from patients with metastatic castration-resistant prostate cancer

scientific article published on 09 March 2015

A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity

scientific article

A simple HPLC-UV method for quantification of enzalutamide and its active metabolite N-desmethyl enzalutamide in patients with metastatic castration-resistant prostate cancer

scientific article published on 5 April 2017

A simple HPLC-UV method for the simultaneous quantification of gefitinib and erlotinib in human plasma.

scientific article

Affinity chromatography for purification of the modular protein growth factor receptor-bound protein 2 and development of a screening test for growth factor receptor-bound protein 2 Src homology 3 domain inhibitor using peroxidase-linked ligand.

scientific article

An HPLC-UV method for the simultaneous quantification of vemurafenib and erlotinib in plasma from cancer patients.

scientific article

Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A.

scientific article

Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration

scientific article

Circulating Tumor DNA Measurement by Picoliter Droplet-Based Digital PCR and Vemurafenib Plasma Concentrations in Patients with Advanced BRAF-Mutated Melanoma.

scientific article published on 19 May 2017

Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib

scientific article published on 29 August 2016

Clinical pharmacology, drug-drug interactions and safety of pazopanib: a review

scientific article

Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor

scientific article

Cyclic peptides as VEGF receptor antagonist

scientific article published in January 2009

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators

scientific article

Design and synthesis of C-terminal modified cyclic peptides as VEGFR1 antagonists.

scientific article

Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2

scientific article

Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains.

scientific article

Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents.

scientific article published on December 2010

Development of a chemiluminescent screening assay for detection of vascular endothelial growth factor receptor 1 ligands

scientific article published on 30 March 2007

Development of binding assays for the SH2 domain of Grb7 and Grb2 using fluorescence polarization

scientific article published on 23 January 2008

Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement

scientific article

Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway

scientific article

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

article

Drug safety evaluation of sorafenib for treatment of solid tumors: consequences for the risk assessment and management of cancer patients

scientific article published on 03 April 2014

Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study

scientific article

Erlotinib pharmacokinetics: a critical parameter influencing acute toxicity in elderly patients over 75 years-old

scientific article published on 29 October 2016

Functional and clinical evidence of the influence of sorafenib binding to albumin on sorafenib disposition in adult cancer patients.

scientific article

Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel

scientific article

Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.

scientific article published on 27 September 2016

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.

scientific article published on 4 February 2013

Identification of Peptidic Antagonists of Vascular Endothelial Growth Factor Receptor 1 by Scanning the Binding Epitopes of Its Ligands.

scientific article

Inhibitors of Ras signal transduction as antitumor agents

scientific article

Investigational therapies up to Phase II which target PDGF receptors: potential anti-cancer therapeutics.

scientific article

Model systems for oxidative drug metabolism studies. Catalytic behavior of water-soluble metalloporphyrins depends on both the intrinsic robustness of the catalyst and the nature of substrates

scientific article published on 01 September 1993

Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin

scientific article

On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition

scientific article published on 22 August 2007

Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.

scientific article

Plasma vemurafenib exposure and pre-treatment hepatocyte growth factor level are two factors contributing to the early peripheral lymphocytes depletion in BRAF-mutated melanoma patients

scientific article published on July 2016

Quality control of extracorporeal photochemotherapy: Proliferation assay using CFSE validated according to ISO 15189:2007 standards

scientific article published on 16 September 2014

Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor.

scientific article

Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1

scientific article

Relation between plasma trough concentration of abiraterone and prostate-specific antigen response in metastatic castration-resistant prostate cancer patients.

scientific article published on 24 December 2016

Role of the lean body mass and of pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of sunitinib in cancer patients.

scientific article

SH2 and SH3 domains as targets for anti-proliferative agents

scientific article

Sarcopenia predicts early dose-limiting toxicities and pharmacokinetics of sorafenib in patients with hepatocellular carcinoma

scientific article (publication date: 2012)

Search for new anti-angiogenic agents with structural analogy with thalidomide

scientific article published in January 2005

Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain

scientific article published on 01 September 1999

Soluble VEGFR-1: a new biomarker of sorafenib-related hypertension (i.e., sorafenib-related is the compound adjective?).

scientific article published on 30 December 2014

Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs

Structure-based design of a bicyclic peptide antagonist of the vascular endothelial growth factor receptors.

scientific article published on June 2008

Synthetic route to dinuclear platinum(II) complexes [{trans-PtCl(NH3)2}2(mu-L)]2+ (L = aliphatic or heterocyclic diamine) as potential antitumor agents, exploiting the mutual activation of hydroxido ligands and ammonium groups.

scientific article published on 26 September 2008

TGF-β2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP-1-signaling and augments invasiveness of Theileria-transformed macrophages. ⬇️

scientific article published on 29 October 2015

Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential.

scientific article published on 14 January 2014

Targeting the proangiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening

scientific article

The cytotoxicity of a Grb2-SH3 inhibitor in Bcr-Abl positive K562 cells

scientific article

The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix

scientific article

VEGFR1 domain 2 covalent labeling with horseradish peroxidase: Development of a displacement assay on VEGF.

scientific article published on 3 May 2017

Vascular Endothelial Growth Factor Peptide Ligands Explored by Competition Assay and Isothermal Titration Calorimetry

scientific article published on 13 August 2015

Vemurafenib pharmacokinetics and its correlation with efficacy and safety in outpatients with advanced BRAF-mutated melanoma

scientific article published on 25 July 2015

Paulina is supported by:

About Paulina

Help