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List of works by Jarkko Rautio

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

scientific article published on 14 July 2016

Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).

scientific article published on 8 October 2014

Amino acid prodrugs for oral delivery: challenges and opportunities

scientific article published on 01 August 2011

Amino acids as promoieties in prodrug design and development ⬇️

scientific article published on October 22, 2012

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media

scientific article published on 01 January 2007

Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma

scientific article

Brain uptake of ketoprofen-lysine prodrug in rats

scientific article published on 19 August 2010

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

scientific article published on 28 December 2017

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes.

scientific article

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children

scientific article published in October 2007

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin

scientific article published on 01 June 2013

Cytochrome P450-activated prodrugs: targeted drug delivery.

scientific article published on January 2008

Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.

scientific article published in October 2013

Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone.

scientific article

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor

scientific article published on 19 February 2010

Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome p450-activated prodrugs.

scientific article published on 31 August 2012

Diclofenac readily penetrates the cerebrospinal fluid in children.

scientific article published on June 2008

Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure

scientific article published in February 2006

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

scientific article

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

scientific article published on 3 September 2016

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.

scientific article published in May 2009

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug

scientific article published on 16 September 2014

How readily does ketorolac penetrate cerebrospinal fluid in children?

scientific article

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin

scientific article published on 30 May 2012

In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen

scientific article published on 01 December 1998

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

scientific article published on 2 February 2006

Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases.

scientific article published in January 2005

Inhibitors of LRRK2 Kinase Activity To Probe the Treatment Option in Parkinson’s Disease ⬇️

scientific article published on October 18, 2012

Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders

scientific article published on 18 December 2020

LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?

scientific article

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery

scientific article published on 9 August 2011

Large neutral amino acid transporter enables brain drug delivery via prodrugs

scientific article published on 25 January 2008

Midazolam exhibits characteristics of a highly permeable P-glycoprotein substrate.

scientific article published on May 2003

Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality

scientific article published on 15 February 2007

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation

scientific article published on 01 August 2000

Plasma and cerebrospinal fluid concentrations of indomethacin in children after intravenous administration

scientific article published in January 2007

Prodrug approaches for CNS delivery

scientific article published on 05 February 2008

Prodrugs - Recent approvals and a glimpse of the pipeline.

scientific article

Prodrugs - an efficient way to breach delivery and targeting barriers.

scientific article published on January 2011

Prodrugs in medicinal chemistry and enzyme prodrug therapies

scientific article published on July 2017

Prodrugs--from serendipity to rational design.

scientific article

Prodrugs: design and clinical applications.

scientific article published on March 2008

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

scientific article published on 9 September 2014

Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells

scientific article published on 27 October 2019

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

scientific article published on 8 December 2012

Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives.

scientific article

Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl)propionic acid as novel naproxen prodrugs for dermal drug delivery

scientific article published on 01 August 1999

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (Naproxen) for topical drug delivery

scientific article

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol.

scientific article

Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.

scientific article published in March 2002

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

scientific article

Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

scientific article published on 20 March 2020

[Prodrug technology in the development of medicinal agents]

scientific article published on 01 January 2011

[Prodrugs]

scientific article published on 01 January 1997

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