List of works by Irene Volitakis

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

scientific article published on 20 May 2013

Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain

scientific article

Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice

scientific article published on 21 April 2009

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

scientific article

Correction: Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine.

scientific article published on 13 November 2013

Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein

scientific article

Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation

scientific article

Decreased serum zinc is an effect of ageing and not Alzheimer's disease.

scientific article published in July 2014

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

scientific article published on 28 April 2006

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

scientific article published on November 2007

Elevated labile Cu is associated with oxidative pathology in Alzheimer disease

scientific article published on 24 October 2011

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

scientific article

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

scientific article published on 6 March 2006

Genetically Decreased Spinal Cord Copper Concentration Prolongs Life in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

article

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

scientific article published on 13 October 2005

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

scientific article

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

scholarly article

Insights into Zn2+ homeostasis in neurons from experimental and modeling studies

scientific article

Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

scientific article

Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms

scientific article

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

scientific article

Iron accumulates in Huntington's disease neurons: protection by deferoxamine

scientific article

Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing

scientific article published on 10 March 2016

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

scientific article published on 4 February 2013

Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease

scientific article published in January 2013

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

scientific article

Mechanisms of copper ion mediated Huntington's disease progression

scientific article

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

scientific article

Mitochondrial oxidative stress causes hyperphosphorylation of tau.

scientific article

Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease.

scientific article

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

scientific article published in March 2004

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

scientific article

Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model

scientific article

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

scientific article published on 4 September 2002

Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease

scientific article published on 19 June 2009

Plasma amyloid beta42 and amyloid beta40 levels are associated with early cognitive dysfunction after cardiac surgery

scientific article published in November 2009

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

scholarly article

Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity

scientific article

Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease

scientific article published in February 2006

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

scientific article

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

scientific article published on 9 March 2011

Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

scientific article

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

scientific article published on November 2009

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

scientific article published on 29 January 2012

The APOE ε4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease

scientific article published on 28 April 2017

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

scientific article

Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid

scientific article

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