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List of works by Mark W. Richards

A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation

scientific article

A closed conformation of the Caenorhabditis elegans separase-securin complex ⬇️

scientific article published on 13 April 2016

A moving target: structure and disorder in pursuit of Myc inhibitors ⬇️

scientific article

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain ⬇️

scientific article published on July 2016

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

scientific article

Ca2+ channel beta-subunits: structural insights AID our understanding

scientific article

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches ⬇️

scientific article

Combined inhibition of Aurora-A and ATR kinase results in regression of <i>MYCN</i>-amplified neuroblastoma

scientific article published on 11 February 2021

Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding

scientific article

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

scientific article

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

scientific article

Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer ⬇️

scientific article published on 29 December 2016

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex. ⬇️

scientific article published on 11 December 2017

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

scientific article published on 4 May 2015

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

scientific article

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

scientific article published on 2 November 2015

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

scientific article

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

scientific article published on 13 August 2019

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release ⬇️

scientific article published on 14 August 2018

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix. ⬇️

scientific article published on 6 March 2018

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

scientific article

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs ⬇️

scientific article

Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma

scientific article published on 05 October 2020

Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels

scientific article published on 6 January 2006

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors ⬇️

scientific article

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

scientific article

The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.

scientific article

The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function

scientific article

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