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List of works by Lawrence H. Lash

A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions

scientific article

Activities of enzymes involved in renal cellular glutathione metabolism after uninephrectomy in the rat

scientific article published on 01 February 1994

Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.

scientific article published on 6 January 2016

Adaptive changes in renal mitochondrial redox status in diabetic nephropathy

scientific article published on 07 November 2011

Adenosine modulates methylmercuric chloride (MeHgCl)-induced D-aspartate release from neonatal rat primary astrocyte cultures.

scientific article

Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese

scientific article published in January 2006

Apoptosis, Necrosis, and Cell Proliferation Induced by S-(1,2-Dichlorovinyl)-l-cysteine in Primary Cultures of Human Proximal Tubular Cells ⬇️

scientific article published on November 15, 2001

Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.

scientific article published on 9 November 2011

Binding of mercury in renal brush-border and basolateral membrane-vesicles

scientific article published on 01 June 1997

Cellular and subcellular heterogeneity of glutathione metabolism and transport in rat kidney cells

scientific article published on 01 September 1998

Cellular energetics and glutathione status in NRK-52E cells: toxicological implications.

scientific article published on November 2002

Compartmentation of glutathione: implications for the study of toxicity and disease.

scientific article published on September 1996

Cystine alters the renal and hepatic disposition of inorganic mercury and plasma thiol status

scientific article published on 8 February 2006

Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.

scientific article

Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells

scientific article

Depletion of cellular glutathione by conditions used for the passaging of adherent cultured cells

scientific article published on 01 May 2000

Diabetes increases susceptibility of primary cultures of rat proximal tubular cells to chemically induced injury.

scientific article published on 12 August 2009

Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: dispositional changes one hour after the intravenous administration of mercuric chloride

scientific article published on 01 January 1999

Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors

scientific article published on 29 August 2009

Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints.

scientific article published in July 2002

Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport

scientific article published on 01 January 2000

Epidermal growth factor receptor ligands and renal epithelial cell proliferation

scientific article published on 23 January 2008

Genetics and susceptibility to toxic chemicals: do you (or should you) know your genetic profile?

scientific article

Glutathione conjugation of perchloroethylene in rats and mice in vitro: sex-, species-, and tissue-dependent differences

scientific article published in May 1998

Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus

scientific article published on 21 October 2005

Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells

scientific article published on 14 March 2008

Hypoxia and oxygen dependence of cytotoxicity in renal proximal tubular and distal tubular cells

scientific article published on 01 January 1993

In vitro nephrotoxicity induced by N-(3,5-dichlorophenyl)succinimide (NDPS) metabolites in isolated renal cortical cells from male and female Fischer 344 rats: evidence for a nephrotoxic sulfate conjugate metabolite.

scientific article published in June 2001

Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemically induced injury

scientific article published on 12 September 2006

Influence of renal compensatory hypertrophy on mitochondrial energetics and redox status

scientific article published on 17 October 2010

Intracellular distribution of thiols and disulfides: assay of mitochondrial glutathione transport

scientific article published on 01 January 1995

Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures

scientific article published on 01 November 1994

Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity

scientific article published on 7 March 2007

Manganese-induced cytotoxicity in dopamine-producing cells

journal article published in 2004

Membrane transport function in primary cultures of human proximal tubular cells

scientific article published on 01 September 2006

Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine

scientific article

Metabolism and toxicity of trichloroethylene in epididymis and testis.

scientific article published in August 2002

Metallothionein induction in fetal rat brain and neonatal primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0).

scientific article published on December 1997

Mitochondrial GSH transport and intestinal cell injury: a commentary on "Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis".

scientific article published on 7 November 2007

Mitochondrial glutathione transport: physiological, pathological and toxicological implications.

scientific article

Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis

scientific article

Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.

scientific article

Modulation of mitochondrial glutathione status and cellular energetics in primary cultures of proximal tubular cells from remnant kidney of uninephrectomized rats ⬇️

scientific article published on February 16, 2013

Molecular markers of trichloroethylene-induced toxicity in human kidney cells.

scientific article published in August 2005

Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of non-viral redox-responsive delivery vectors

scientific article published on 2 April 2008

Oxidative stress and cytotoxicity of 4-(2-thienyl)butyric acid in isolated rat renal proximal tubular and distal tubular cells

scientific article published on 01 December 1995

Oxidative stress is induced in the rat brain following repeated inhalation exposure to manganese sulfate.

scientific article published in January 2003

PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1

scientific article

Pathways of glutathione metabolism and transport in isolated proximal tubular cells from rat kidney

scientific article published on 01 July 1996

Placenta as a target of trichloroethylene toxicity

scientific article published on 05 February 2020

Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene

scientific article published on 3 November 2005

Relationships between alterations in glutathione metabolism and the disposition of inorganic mercury in rats: effects of biliary ligation and chemically induced modulation of glutathione status

scientific article published on 01 December 1999

Renal cell type specificity of cephalosporin-induced cytotoxicity in suspensions of isolated proximal tubular and distal tubular cells

scientific article published on 01 November 1994

Renal cellular transport of exogenous glutathione: heterogeneity at physiological and pharmacological concentrations

scientific article published on 01 September 1999

Renal cellular transport, metabolism, and cytotoxicity of S-(6-purinyl)glutathione, a prodrug of 6-mercaptopurine, and analogues

scientific article published on 01 December 1997

Renal glutathione transport: Identification of carriers, physiological functions, and controversies.

scientific article

Renal membrane transport of glutathione in toxicology and disease.

scientific article published on 23 July 2010

Role of cytochrome P450 and glutathione S-transferase alpha in the metabolism and cytotoxicity of trichloroethylene in rat kidney

scientific article published in March 2000

Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells

scientific article

Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth

scientific article published on 14 September 2005

Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione

scientific journal article

Role of voltage-dependent anion channels in glutathione transport into yeast mitochondria

scientific article published in October 2000

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

scientific article published on 23 January 2018

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps

scientific article

The mitochondrial benzodiazepine receptor as a potential target protein for drug development: demonstration of functional significance with cell lines exhibiting differential expression of Bcl-2.

scientific article published on July 2003

The renal thiol (glutathione) oxidase subcellular localization and properties ⬇️

scientific article published on June 25, 1984

Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells

scientific article published on 05 May 2018

Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity

scientific article

Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats

scientific article published on 20 November 2018

Uptake of glutathione by renal cortical mitochondria

scientific article published on 01 August 1991

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