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List of works by Hironobu Yasui

3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines.

scientific article published on January 2014

8-Aminoadenosine enhances radiation-induced cell death in human lung carcinoma A549 cells.

scientific article

A Novel PET Probe "[18F]DiFA" Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism

scientific article published on 01 February 2019

A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

scientific article

A new amphiphilic derivative, N-{[4-(lactobionamido)methyl]benzylidene}-1,1-dimethyl-2-(octylsulfanyl)ethylamine N-oxide, has a protective effect against copper-induced fulminant hepatitis in Long-Evans Cinnamon rats at an extremely low concentratio

scientific article published in September 2007

A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression.

scientific article

Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.

scientific article published on 8 December 2014

Analysis of the mechanism of radiation-induced upregulation of mitochondrial abundance in mouse fibroblasts

scientific article published on 14 December 2016

Anti PD-1 treatment increases [F]FDG uptake by cancer cells in a mouse B16F10 melanoma model

scientific article published on 16 August 2018

Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.

scientific article

Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.

scientific article published on 23 February 2018

Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO

scientific article published on 05 July 2019

Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation.

scientific article

Differentiation of bone marrow-derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation

scientific article published on 09 January 2019

Downregulation of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 stimulates transforming growth factor-β1 production and promotes actin rearrangement.

scientific article

Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft.

scientific article published on 12 December 2016

EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3‐bromopyruvate ⬇️

scientific article published on June 12, 2012

ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.

scientific article published on 7 September 2013

Electron paramagnetic resonance imaging of tumor pO₂.

scientific article published on 14 February 2012

Enhancement of cell death by TNF alpha-related apoptosis-inducing ligand (TRAIL) in human lung carcinoma A549 cells exposed to x rays under hypoxia

scientific article

Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo

scientific article published on 04 December 2019

Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR.

scientific article published on 5 April 2018

Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro

scientific article published on February 2016

Feasibility of in vivo three-dimensional T 2* mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging.

scientific article published on 6 January 2017

Imaging cycling tumor hypoxia.

scientific article

In vivo extracellular pH mapping of tumors using electron paramagnetic resonance

scientific article published on 08 November 2018

In vivo tumour extracellular pH monitoring using electron paramagnetic resonance: the effect of X-ray irradiation

scientific article

Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells.

scientific article published in June 2010

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation.

scientific article

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint.

scientific article published on 8 May 2012

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells.

scientific article published on 13 January 2017

Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.

scientific article

Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets

scientific article

Mitochondrial fission promotes radiation-induced increase in intracellular Ca2+ level leading to mitotic catastrophe in mouse breast cancer EMT6 cells

scientific article published on 19 November 2019

Preclinical study on hypoxic radiosensitizing effects of glycididazole in comparison with those of doranidazole in vitro and in vivo.

scientific article published on 23 November 2017

Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation

scientific article published in October 2017

Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model.

scientific article published on 2 July 2013

Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.

scientific article published on 14 February 2014

Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.

scientific article

Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells

scientific article

Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI.

scientific article published on 06 October 2009

The Adjuvant Effect of Squalene, an Active Ingredient of Functional Foods, on Doxorubicin-Treated Allograft Mice

scientific article published on 10 June 2019

The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption.

scientific article

Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice

scientific article published on 01 May 2007

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells

scientific article

Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography.

scientific article published on September 2008

X irradiation combined with TNF alpha-related apoptosis-inducing ligand (TRAIL) reduces hypoxic regions of human gastric adenocarcinoma xenografts in SCID mice

scientific article published on 26 January 2008

[18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia

scientific article published on 2 May 2018

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